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    Functional neuroimaging for addiction medicine: From mechanisms to practical considerations

    , Article Progress in Brain Research ; Volume 224 , 2016 , Pages 129-153 ; 00796123 (ISSN) ; 9780444637161 (ISBN) Ekhtiari, H ; Faghiri, A ; Oghabian, M. A ; Paulus, M. P ; Ekhtiari H. E ; Paulus M. P ; Sharif University of Technology
    Elsevier  2016
    During last 20 years, neuroimaging with functional magnetic resonance imaging (fMRI) in people with drug addictions has introduced a wide range of quantitative biomarkers from brain's regional or network level activities during different cognitive functions. These quantitative biomarkers could be potentially used for assessment, planning, prediction, and monitoring for "addiction medicine" during screening, acute intoxication, admission to a program, completion of an acute program, admission to a long-term program, and postgraduation follow-up. In this chapter, we have briefly reviewed main neurocognitive targets for fMRI studies associated with addictive behaviors, main study types using... 

    The social work services in screening process of compulsory treatment interventions in addicts in Iran: a content analysis study

    , Article Asian Social Work and Policy Review ; Volume 12, Issue 2 , 2018 , Pages 86-93 ; 17531403 (ISSN) Moghanibashi Mansourieh, A ; Fathi, M ; Barati Sedeh, F ; Deilamizade, A ; Puyan, D ; Sharif University of Technology
    Blackwell Publishing  2018
    Compulsory treatment has had a detrimental impact on drug abuse treatment policies and programs in Iran. Physicians are currently required to conduct initial treatment screening. Social workers are a part of the treatment team but have no authority to initiate a compulsory drug treatment plan. For this reason, the present article investigates social work service participation in the process of compulsory drug treatment. The study methodology is content analysis. Nine social workers participated in seven focus group discussions. Overall, 110 codes were extracted from the sessions and were categorized into five main themes: interview and initial assessment; referral; investigation of... 

    Individual differences in nucleus accumbens dopamine receptors predict development of addiction-like behavior: A computational approach

    , Article Neural Computation ; Volume 22, Issue 9 , 2010 , Pages 2334-2368 ; 08997667 (ISSN) Piray, P ; Keramati, M. M ; Dezfouli, A ; Lucas, C ; Mokri, A ; Sharif University of Technology
    Clinical and experimental observations show individual differences in the development of addiction. Increasing evidence supports the hypothesis that dopamine receptor availability in the nucleus accumbens (NAc) predisposes drug reinforcement. Here, modeling striatal-midbrain dopaminergic circuit, we propose a reinforcement learning model for addiction based on the actor-critic model of striatum. Modeling dopamine receptors in the NAc as modulators of learning rate for appetitive-but not aversive-stimuli in the critic-but not the actor-we define vulnerability to addiction as a relatively lower learning rate for the appetitive stimuli, compared to aversive stimuli, in the critic. We... 

    Functional Mapping of Regions Involved In Addiction Using Magnetic Resonance Imaging and Proposing a New Measure for Multivariate Methods

    , M.Sc. Thesis Sharif University of Technology Faghiri, Ashkan (Author) ; Vosughi Vahdat, Bijan (Supervisor) ; Ekhtiari, Hamed (Co-Advisor)
    Methamphetamine (meth) abuse and addiction (MA), with its serious medical, psychiatric and social complications, is a growing national disaster in Iran. Response control deficit during exposure to drug related cues is one of the main neurocognitive cores in MA and results in continued drug use and treatment failure. There have been many studies focused on cue exposure, but most of their paradigms required subjects to passively view the cues; this aspect of these paradigms cause a wide gap between reality and experimental studies. Developing a functional and structural neuroimaging protocol to map realistic brain circuits that are involved in craving among meth users is of importance.... 

    Is Neurological Research Support New Social Media Injuries ?

    , M.Sc. Thesis Sharif University of Technology Rasouli, Somayeh (Author) ; Hosseini, Hassan (Supervisor)
    For more than two decades psychologists and sociologists have been warning about the damage of new social media. in the last decade, the neurological research has been developed to provide an empirical foundation to support the above hypothesis. Much of the research has focused on teenagers and young adults as the so-called digital native and as the largest number of social media users. They hold that a significant contribution to the adolescent trend plays a significant role in the tendency of individuals toward social media, thus increasing impulsive behavior. The three parts of the brain, namely the "social cognition network," the "self-referential cognition network" and the "reward... 

    Electrochemical determination of naltrexone on the surface of glassy carbon electrode modified with Nafion-doped carbon nanoparticles: Application to determinations in pharmaceutical and clinical preparations

    , Article Journal of Electroanalytical Chemistry ; Volume 638, Issue 2 , 2010 , Pages 212-217 ; 15726657 (ISSN) Ghorbani Bidkorbeh, F ; Shahrokhian, S ; Mohammadi, A ; Dinarvand, R ; Sharif University of Technology
    A new sensitive and selective electrochemical sensor was developed for determination of naltrexone (NAL) in pharmaceutical dosage form and human plasma. Naltrexone is an opioid antagonist which is commonly used for the treatment of narcotic addiction and alcohol dependence. A voltammetric study of naltrexone has been carried out at the surface of glassy carbon electrode (GCE) modified with Nafion-doped carbon nanoparticles (CNPs). The electrochemical oxidation of naltrexone was investigated by cyclic and differential pulse voltammetric techniques. The dependence of peak currents and potentials on pH, concentration and the potential scan rate was investigated. The electrode characterization...