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beta-cyclodextrins
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In vitro biocompatibility evaluations of hyperbranched polyglycerol hybrid nanostructure as a candidate for nanomedicine applications
, Article Journal of Materials Science: Materials in Medicine ; Vol. 25, issue. 2 , 2014 , pp. 499-506 ; ISSN: 09574530 ; Shokrgozar, M. A ; Vossoughi, M ; Farokhi, M ; Sharif University of Technology
Abstract
In the present study, a detailed biocompatibility testing of a novel class of hybrid nanostructure based on hyperbranched polyglycerol and β-cyclodextrin is conducted. This highly water soluble nanostructure with size of less than 10 nm, polydispersity of less than 1.3, chemical tenability and highly branched architecture with the control over branching structure could be potentially used as a carrier in drug delivery systems. To this end, extensive studies in vitro and in vivo conditions have to be demonstrated. The in vitro studies include in vitro cytotoxicity tests; MTT and Neutral Red assay as an indicator of mitochondrial and lysosomal function, and blood biocompatibility tests such as...
Preparation of Nanoparticles Based on Hyperbranched Polyglycerol as Anti Cancer Drug Delivery Systems
, M.Sc. Thesis Sharif University of Technology ; Pourjavadi, Ali (Supervisor) ; Adeli, Mohsen (Co-Advisor)
Abstract
Successful formulation development for poor water soluble drugs is a critical, long-standing and challengeable problem in cancer treatment. One of the methods for transporting low-soluble drugs is using nanoparticles which are able to pass through capillary walls of tumor tissues due to their small size. An example of the nanoparticles is micelle systems. Functionalized β-cyclodextrin (β-CD) by hyper branched polyglycerol (HPG) can dissolve low-soluble compounds. This polymer can be used in preparing micelles. In this project, β-cyclodextrin (β-CD) by anionic reactions is initiator for polymerization of glycidol monomer. Hydrophobic cavity of the β-cyclodextrin (β-CD) in placing the phenyl...
Experimental Study of the β-CD-g-PG Hybrid Nanostructure On Phase Solubilityof Hydrophobic Drug
, M.Sc. Thesis Sharif University of Technology ; Saifkordi, Aliakbar (Supervisor) ; Vossoughi, Manouchehr (Supervisor)
Abstract
Some widely used drugs such as paclitaxel (PTX) are poorly water soluble. The clinical use of PTX with solubilizer causes side effects. These problems limited its application in treatments. In this work has been studied the effect of β-CD-g-PG (HPCD) hybrid nanomaterials, conjugated PG branches onto β-CD core, on the water solubility of PTX. First HPCD has been synthesized. Then the inclusion complex of PTX with HPCD was prepared. The inclusion complex efficiency for PTX:HPCD complex in 1:25 mole ratio was 87%. Then solubility of PTX with HPCD in water has been determined, showing Ap type phase solubility diagram. Then stability constants were calculated. The first order and second order...
Investigation of phase Solubility Enhancement of Paclitaxel by Inclusion Complex of drug in B-CD-g-PG
, M.Sc. Thesis Sharif University of Technology ; Yaghmaei, Soheyla (Supervisor) ; Vossoughi, Manoochehr (Supervisor) ; Kazemi Daliri, Akhtarolmoluk (Supervisor)
Abstract
Paclitaxel is using as a drug against breast and ovary cancers. Although paclitaxel has high biologic activity, it has very poor solubility in water the same as some other drugs. Since drugs should be solved in water to be absorbed by the body, for absorb enhancement, we should use carriers which includes both polar and non polar sites.
Beta-Cyclodextrin which has this feature is capable for producing inclusion complex in its hydrophobic pores with non polar materials. In this project, by adding polymeric polyglycerol branches on Beta-Cyclodextrin, a polymeric nanostructure has been developed to enhance water solubility in comparison with pure Beta-Cyclodextrin.
Study on producing...
Beta-Cyclodextrin which has this feature is capable for producing inclusion complex in its hydrophobic pores with non polar materials. In this project, by adding polymeric polyglycerol branches on Beta-Cyclodextrin, a polymeric nanostructure has been developed to enhance water solubility in comparison with pure Beta-Cyclodextrin.
Study on producing...
Design and Synthesis of a Novel Nanomaterial as a Carrier of a Hydrophobe drug in an Inclusion Complex based on Cychlodextrin
, M.Sc. Thesis Sharif University of Technology ; Vossoughi, Manouchehr (Supervisor) ; Kazemi, Akhtarolmolouk (Supervisor)
Abstract
Paclitaxel is used as a drug against breast and ovarian cancers. Although paclitaxel has high biologic activity, it has very pour solubility in water like some other drugs. Since drugs should be solved in water to be absorbed by the body, for absorb enhancement, we should use carriers which includes both polar and non polar sites. eta-Cyclodextrin which has this feature is capable for producing inclusion complex in its hydrophobic pores with non polar materials. In this project by adding polymeric polyacrylamide branches on beta-Cyclodextrin, polymeric nano structure has been developed to enhance water solubility in comparison with pure beta-Cyclodextrin. Study on producing polymeric nano...
Synthesis and Evaluation of Supramolecular Nanostrutures of Cyclodextrin/Polyglycerol with Controlled Drug Delivery Applications
, Ph.D. Dissertation Sharif University of Technology ; Vossoughi, Manouchehr (Supervisor) ; Adeli, Mohsen (Supervisor) ; Shokrgozar, Mohammad Ali (Supervisor)
Abstract
Today, human is facing and struggling with one of the most deadly disease, Cancer. Accordingly, several research studies are aimed to develop new anticancer drugs. Among the prescribed drugs are Paclitaxel. Unfortunately, despite the anticancer activity, paclitaxel has very low water solubility. To solve this problem several alternatives have been proposed by researchers, e.g. using co-solvents of ethanol:Cremophor El®, as is the case in commercial drug, Taxol®. Unfortunately, these co-solvents have some dangerous and sometimes mortal side effects. To reduce its side effects, researchers have proposed using cyclodextrin as a carrier for paclitaxel on the basis that cyclodextrin has a...
The Study of Antioxidant Mechanism of some Flavonoids without and in Presence of Cyclodextrins: Theoretical Point of View
, Ph.D. Dissertation Sharif University of Technology ; Tafazzoli, Mohsen (Supervisor) ; Ghiasi, Mina (Co-Supervisor)
Abstract
Antioxidants are compounds with anti-cancer, anti-bacterial, anti-viral, anti-aging and anti-allergic properties. In the present study, a quantum mechanical approach has been used to shed light on the presence effect of glycoside group on the antioxidant ability of chrysin as one of the most important consumable flavonoids and two glycoside derivatives, chrysin-6-C-fucopyranoside and chrysin-3-malonyl-6-C-fucopyranoside which has electron-withdrawing group (EWG) in its C3 of glycoside group. Density functional theory (DFT) using B3LYP and UB3LYP functional and split-valance 6-311++G ** basis set were used to optimize chrysin, its different derivatives, and their radicals. Analysis of...
Preparation of Host-Guest Hydrogels Responsive to Environmental Stimuli based on Diazo Compounds for Drug Release
, M.Sc. Thesis Sharif University of Technology ; Pourjavadi, Ali (Supervisor)
Abstract
Conventional chemotherapy methods impact both normal and cancerous cells; therefore, it is essential to design novel drug delivery systems in order to reduce drugs’ side effects. Having high retention time in blood and the capability of crossing blood-brain barriers are the characteristics of nano-scaled drug delivery systems.The research thesis is about the synthesis and characterization of the light-sensitive biocompatible nanogels with the core-shell structure with the intention of Doxorubicin anti-cancer drug delivery. These smart nanogels possess a hydrophobic core coated with hydrophilic starch polymeric chain modified with beta-cyclodextrin. The formation of the core-shell structure...
Fully supramolecular vesicles as anticancer drug delivery systems
, Article New Journal of Chemistry ; Volume 37, Issue 2 , 2013 , Pages 295-298 ; 11440546 (ISSN) ; Adeli, M ; Yazdi, M ; Sharif University of Technology
2013
Abstract
A supramolecular linear-dendritic copolymer consisting of a polystyrene backbone and hanging hyperbranched polyglycerols was prepared and characterized. Host-guest interactions between β-cyclodextrin incorporated in the core of polyglycerol as a host and aromatic rings of polystyrene as guests lead to the formation of a supramolecular linear-dendritic copolymer. Supramolecules formed micelles in aqueous solutions which were able to encapsulate and transfer paclitaxel with a high loading capacity
Smart and fragrant garment via surface modification of cotton fabric with cinnamon oil/stimuli responsive PNIPAAm/chitosan nano hydrogels
, Article IEEE Transactions on Nanobioscience ; Volume 16, Issue 6 , 2017 , Pages 455-462 ; 15361241 (ISSN) ; Hemmatinejad, N ; Pourjavadi, A ; Sharif University of Technology
Abstract
This paper deals with obtaining aromatherapic textiles via applying stimuli-responsive poly N-isopropyl acryl amide (PNIPAAm) chitosan (PNCS) nano hydrogels containing cinnamon oil on cotton fabric and looks into the treated fabric characteristics as an antibacterial and temperaturepH responsive fabric. The semi-batch surfactant-free dispersion polymerization method was proposed to the synthesis of PNCS nano particles. The incorporation of modified β -cyclodextrin ( β-CD) into the PNCS nanohydrogel was performed in order to prepare a hydrophobic(cinnamon oil) carrier embedded in stimuli-responsive nanohydrogel. The β -CD postloading process of cinnamon oil in to the hydrogel nano particles...
Poly(N-isopropylacrylamide)-coated β-cyclodextrin–capped magnetic mesoporous silica nanoparticles exhibiting thermal and pH dual response for triggered anticancer drug delivery
, Article International Journal of Polymeric Materials and Polymeric Biomaterials ; Volume 66, Issue 7 , 2017 , Pages 336-348 ; 00914037 (ISSN) ; Mazaheri Tehrani, Z ; Sharif University of Technology
Taylor and Francis Inc
2017
Abstract
In this research a novel controlled anticancer drug delivery system with dual pH and thermal responses was designed based on magnetic mesoporous silica nanoparticles that were anchored by β-cyclodextrin and coated by poly(N-isopropylacrylamide) (PNIPAM). Results demonstrated that the behavior of doxorubicin (anticancer drug) release depended on pH and temperature conditions. At endosomal pH (pH 5.5) the amount of drug release enhanced because the cap was removed from the pores. Furthermore, PNIPAM shell collapsed above the lower critical solution temperature and the releasing of drug increased. Thus, this nanocarrier would have the potential to be applied in the tumor therapy. © 2017 Taylor...
Thermo- and pH-sensitive dendrosomes as bi-phase drug delivery systems
, Article Nanomedicine: Nanotechnology, Biology, and Medicine ; Volume 9, Issue 8 , 2013 , Pages 1203-1213 ; 15499634 (ISSN) ; Fard, A. K ; Abedi, F ; Chegeni, B. K ; Bani, F ; Sharif University of Technology
2013
Abstract
Fully supramolecular dendrosomes (FSD) as bi-phase drug delivery systems are reported in this work. For preparation of FSD, amphiphilic linear-dendritic supramolecular systems (ALDSS) have been synthesized by host-guest interactions between hyperbranched polyglycerol having β-cyclodextrin core and bi-chain polycaprolactone (BPCL) with a fluorescine focal point. Self-assembly of ALDSS in aqueous solutions led to FSD. They were able to encapsulate paclitaxel with a high loading capacity. The dendrosome-based drug delivery systems were highly sensitive to pH and temperature. They were stable at 20-37. °C and pH7-8, but dissociated and released drug at temperatures lower than 20. °C or higher...