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chondrogenesis-process
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Design and Manufacture of an Engineered Scaffold in Order to Repair Tissue Exposed to Mechanical Force, for Tissue Engineering Application
, M.Sc. Thesis Sharif University of Technology ; Shamloo, Amir (Supervisor)
Abstract
Articular cartilage has limited repair capability following traumatic injuries and current methods of treatment remain inefficient. Reconstructing cartilage provides a new way for cartilage repair and natural polymers are often used as scaffold because of their biocompatibility and biofunctionality. The goal of cartilage tissue engineering is to design a scaffold with proper pore structure and similar mechanical properties to the native tissue. In this study Porous scaffolds prepared from silk fibroin, chitosan and gelatin blends with varying ratio of silk fibroin and gelatin by freeze drying method were characterized for physicochemical, mechanical and biological properties. Among the...
Developing Protein-Loaded Modified Hyaluronic Acid Hydrogel for Tissue Regeneration
, M.Sc. Thesis Sharif University of Technology ; Abdekhodaie, Mohammad Jafar (Supervisor)
Abstract
Growth factors play an important role in tissue repair and regeneration including articular cartilage tissue. Direct injection of growth factor is a common practice in clinics. However, it has been shown that this method is not very effective and, in some cases, induces some side effects. Moreover, incorporation of this valuable signals in systems where they are quickly released and washed out is not effective as well. Thereby the aim of this study was to design and fabricate an efficient system to effectively deliver growth factors for cartilage tissue engineering. The designed system is an injectable, in situ forming hydrogel, based on hyaluronic acid (HA) as a biocompatible and attractive...