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    Theoretical study of interaction between tacrine and finite-length Al-doped carbon and boron nitride nanotubes: A semiempirical drug delivery study in thermodynamic view

    , Article Oriental Journal of Chemistry ; Vol. 30, issue. 4 , 2014 , p. 1805-1813 Zeighami, N ; Gholami, M. R ; Aghaie, M ; Boshra, A ; Sharif University of Technology
    Abstract
    In order to extend our previous theoretical calculations that dealt with the thermochemistry of doping the single walled boron nitride nanotubes, BNNTs, and carbon nanotubes, CNTs, with alminium atoms [1], we have used the AM1, PM3, and PM6 semiempirical methods to investigate the interaction of the tacrine molecule (a drug for the treatment of Alzheimer's disease) with the side-walls of aluminum doped boron nitride and carbon nanotubes in thermodynamic views. At first, the frequency calculations were carried out to confirm the stability of the involved structures. In addition, the theoretical thermodynamic study of tacrine adsorption onto the considered nanotubes was performed and the... 

    Nanobiomaterials set to revolutionize drug-delivery systems for the treatment of diabetes: State-of-the-art

    , Article Nanobiomaterials in Drug Delivery: Applications of Nanobiomaterials ; 2016 , Pages 487-514 ; 9780323428897 (ISBN) Yazdanpanah, A ; Rezvani, Z ; Ramedani, A ; Gholipourmalekabadi, M ; Chauhan, N. P. S ; Moztarzadeh, S ; Urbanska, A ; Mozafari, M ; Sharif University of Technology
    Elsevier Inc  2016
    Abstract
    Diabetes can result when the accurate control of insulin levels fails in the body. As a result, insulin has been conventionally administered for the treatment of diabetes mainly through subcutaneous injection. There have been several attempts to administer insulin orally. However, the oral bioavailability of insulin is strictly limited, mainly by low permeability across biological membranes. Advances in biotechnology and nanotechnology have recently led to the discovery of several new approaches for the delivery of drugs. In this concept, nanobiomaterials have been shown to be promising candidates for oral insulin delivery. This chapter describes the recent advances and future prospects of... 

    Synthesis, characterization and biological evaluation of a well dispersed suspension of gallium-68-labeled magnetic nanosheets of graphene oxide for in vivo coincidence imaging

    , Article Radiochimica Acta ; Volume 105, Issue 1 , 2017 , Pages 65-73 ; 00338230 (ISSN) Fazaeli, Y ; Rahighi, R ; Tayyebi, A ; Feizi, S ; Sharif University of Technology
    Walter de Gruyter GmbH  2017
    Abstract
    Graphene oxide (GO) nanosheets were hybridized with Fe3O4 nanoparticles (NPs) to form magnetic GO (MGO) and were further labeled by [68Ga]GaCl3 as a potential drug delivery system. Paper chromatography, Fourier transform infra red (FTIR) spectroscopy, low-angle X-ray diffraction (XRD), CHN and atomic force microscopy (AFM) were utilized to characterize the trinary composite ([68Ga]@MGO). Biological evaluations of the prepared nanocomposite were performed in normal Sprague Dawley rats and it was found to be a possible host for theranostic radiopharmaceuticals. The results showed that the grafting of Fe3O4 NPs on nanocomposite reduced the unwanted liver and spleen uptakes and increased the... 

    Targeted nanomedicines for the treatment of bone disease and regeneration

    , Article Medicinal Research Reviews ; 2020 Ordikhani, F ; Zandi, N ; Mazaheri, M ; Luther, G. A ; Ghovvati, M ; Akbarzadeh, A ; Annabi, N ; Sharif University of Technology
    John Wiley and Sons Inc  2020
    Abstract
    Targeted delivery by either passive or active targeting of therapeutics to the bone is an attractive treatment for various bone related diseases such as osteoporosis, osteosarcoma, multiple myeloma, and metastatic bone tumors. Engineering novel drug delivery carriers can increase therapeutic efficacy and minimize the risk of side effects. Developmnet of nanocarrier delivery systems is an interesting field of ongoing studies with opportunities to provide more effective therapies. In addition, preclinical nanomedicine research can open new opportunities for preclinical bone-targeted drug delivery; nevertheless, further research is needed to progress these therapies towards clinical... 

    Green carbon-based nanocomposite biomaterials through the lens of microscopes

    , Article Emergent Materials ; 2021 ; 25225731 (ISSN) Rabiee, N ; Ahmadi, S ; Rabiee, M ; Bagherzadeh, M ; Vahabi, H ; Jouyandeh, M ; Saeb, M. R ; Sharif University of Technology
    Springer Nature  2021
    Abstract
    In this work, a green synthesis method was designed and practiced to develop bioactive and biocompatible carbon-based nanocomposites biomaterials. ZnO nanoparticles were synthesized in assistance of leaf extracts and added to a composite nanostructure composed of the reduced graphene oxide (rGO) and multi-walled carbon nanotubes (MWCNT). The resulting green nanocomposite revealed ability to make π-π interactions, hydrogen bonding, and van der Waals interactions with the doxorubicin (DOX). Then, the surface morphology of the synthesized nanocomposite was investigated, and the interrelationship between the surface morphology, relative cell viability, and drug uptake and release behavior were... 

    Apoptosis induction, cell cycle arrest and anti-cancer potential of tamoxifen-curcumin loaded niosomes against MCF-7 cancer cells

    , Article Iranian Journal of Pathology ; Volume 17, Issue 2 , 2022 , Pages 183-190 ; 17355303 (ISSN) Fatemizadeh, M ; Tafvizi, F ; Shamsi, F ; Amiri, S ; Farajzadeh, A ; Akbarzadeh, I ; Sharif University of Technology
    Iranian Society of Pathology  2022
    Abstract
    Background & Objective: Breast cancer is the most common cancer among women. One of the most effective treatments for breast cancer is chemotherapy, in which specific drugs destroy the mass and its proliferation is inhibited. Chemotherapy is the most effective adjunctive therapy when multiple medications are used concurrently. Also, combining the drugs with nanocarrier has become an important strategy in targeted therapy. This study is designed to assess the apoptosis induction, cell cycle arrest, and anti-cancer potential of Tamoxifen-Curcumin-loaded niosomes against MCF-7 Cancer Cells. Methods: A novel niosomal formulation of tamoxifen-curcumin with Span 80 and lipid to drug ratio of 20... 

    Micro and nanoscale technologies in oral drug delivery

    , Article Advanced Drug Delivery Reviews ; Volume 157 , 2020 , Pages 37-62 Ahadian, S ; Finbloom, J. A ; Mofidfar, M ; Diltemiz, S. E ; Nasrollahi, F ; Davoodi, E ; Hosseini, V ; Mylonaki, I ; Sangabathuni, S ; Montazerian, H ; Fetah, K ; Nasiri, R ; Dokmeci, M. R ; Stevens, M. M ; Desai, T. A ; Khademhosseini, A ; Sharif University of Technology
    Elsevier B.V  2020
    Abstract
    Oral administration is a pillar of the pharmaceutical industry and yet it remains challenging to administer hydrophilic therapeutics by the oral route. Smart and controlled oral drug delivery could bypass the physiological barriers that limit the oral delivery of these therapeutics. Micro- and nanoscale technologies, with an unprecedented ability to create, control, and measure micro- or nanoenvironments, have found tremendous applications in biology and medicine. In particular, significant advances have been made in using these technologies for oral drug delivery. In this review, we briefly describe biological barriers to oral drug delivery and micro and nanoscale fabrication technologies.... 

    Smart drug delivery: Capping strategies for mesoporous silica nanoparticles

    , Article Microporous and Mesoporous Materials ; Volume 299 , 2020 Bakhshian Nik, A ; Zare, H ; Razavi, S ; Mohammadi, H ; Torab Ahmadi, P ; Yazdani, N ; Bayandori, M ; Rabiee, N ; Izadi Mobarakeh, J ; Sharif University of Technology
    Elsevier B.V  2020
    Abstract
    Systematic delivery of therapeutic agents to specific sites, with a stimulus-responsive drug release profile is currently a rapidly growing area. Mesoporous silica nanoparticles (MSNs) are the useful platforms as drug/gene delivery systems due to their unique properties including the ability to control the pore size, high porosity, and morphology, which can directly affect the mechanism and profile of drug release. The appropriate fabrication strategy can tailor the particle shape and size, leading to enhanced delivery and release mechanisms. The MSN surface can be modified by using either organic or inorganic molecules to induce smart and site-specific drug delivery and release.... 

    Synthesis of Dextran-MA-Gly-Gly-NHNH2 Copolymer as a Possible Biodegradable and pH-responsive Carrier for Doxorubicin

    , M.Sc. Thesis Sharif University of Technology Emami, Zahraosadat (Author) ; Pourjavadi, Ali (Supervisor)
    Abstract
    Some chemotherapy drugs have unpleasant side effects and use them due to the instability and low solubility in blood flow is associated with problems and limitations.To solve these problems, controlled drug delivery systems have been proposed. In this process, the polymer increased solubility, stability and low toxicity and the active drug realease in a particular tissue or controlled speed. Therefore be less adverse side effects. Dextran is the one of biocompatible and water-soluble polysaccharides that due to its unique characteristics, widely used as carriers in drug delivery. Dextran molecules can bind to drugs and increased solubility, stability, and reduce their side effects.... 

    Sustained release intraocular drug delivery devices for treatment of uveitis

    , Article Journal of Ophthalmic and Vision Research ; Volume 6, Issue 4 , Oct , 2011 , Pages 317-319 ; 20082010 (ISSN) Haghjou, N ; Soheilian, M ; Abdekhodaie, M. J ; Sharif University of Technology
    2011
    Abstract
    Corticosteroids have been the mainstay of uveitis therapy. When intraocular inflammation is unresponsive to steroids, or steroid related side effects become a concern, steroid-sparing medications may be administered which can be classified into immunosuppressive and immunomodulatory agents. Uveitis treatment can be delivered systemically, topically, periocularly or intraocularly. All of the above mentioned medications can entail significant systemic side effects, particularly if administered for prolonged durations, which may become treatment-limiting. Some medications, particularly hydrophobic compounds, may poorly cross the blood-retinal barrier. Topical medications, which have the least... 

    Supramolecular hybrid nanomaterials as drug delivery systems

    , Article Supramolecular Chemistry ; Volume 23, Issue 6 , Apr , 2011 , Pages 411-418 ; 10610278 (ISSN) Adeli, M ; Hakimpour, F ; Sagvand, M ; Jaafari, M. R ; Kabiri, R ; Moshari, Z ; Sharif University of Technology
    2011
    Abstract
    Highly fluorescent and water-soluble cadmium selenide quantum dots (QDs) functionalised by thio-cyclodextrin (HS-CD) and mercaptoacetic acid (MAA) as surface coating agents (QDs-CD-MAA) were synthesised successfully. The synthesised hybrid nanomaterials, QDs-CD-MAA, were able to form water-soluble complexes with paclitaxel and folic acid. QDs and their complexes were characterised by usual spectroscopy and microscopy methods. Size and morphology of functionalised QDs were dependent on their capping agents and guest molecules. Short-term in vitro cytotoxicity tests on mouse tissue connective fibroblast adhesive cells (L929) showed that conjugation of CD molecules onto the surface of QDs... 

    Redox-sensitive smart nanosystems for drug and gene delivery

    , Article Current Organic Chemistry ; Volume 20, Issue 28 , 2016 , Pages 2949-2959 ; 13852728 (ISSN) Karimi, M ; Moosavi Basri, S. M ; Vossoughi, M ; Pakchin, P. S ; Mirshekari, H ; Hamblin, M. R ; Sharif University of Technology
    Bentham Science Publishers B.V 
    Abstract
    Background: Smart stimulus-responsive nanocarriers represent a rapidly growing class of drug-delivery systems for cancer and other diseases. Objective: The alterations of redox potential between the intracellular environment and the extracellular space have been widely utilized as a trigger for delivery of therapeutic agents by smart stimulus-responsive nanocarriers. We set out to review the scientific literature. Method: Published papers between 1980 and the present day were surveyed. Results: The advantages of redox-activated smart delivery of drugs, genes, and imaging agents include: the amplitude of the redox-responsive signal; the simple chemical features needed to trigger the... 

    Conjugation of amphotericin B to carbon nanotubes via amide-functionalization for drug delivery applications

    , Article Engineering Letters ; Volume 17, Issue 4 , 2009 ; 1816093X (ISSN) Vossoughi, M ; Gojgini, S ; Kazemi, A ; Alemzadeh, I ; Zeinali, M ; Sharif University of Technology
    2009
    Abstract
    Carbon nanotubes are among promising components for a wide range of applications, due to their unique properties; Specifically, They are a new alternative and efficient tool for transporting and translocating therapeutic molecules since they can translocate easily into the cytoplasm or nucleus of a cell through its membrane without generating an immunogenic response and toxic effects. While pristine carbon nanotubes are insoluble in all solvents, the organic functionalisation of carbon nanotubes is the prerequisite for their solubility profiles and their manipulation into biological systems. For this purpose, in this study, we first report the Amide-functionalization of CNTs which a direct... 

    Enhanced antibacterial activity of echinacea angustifolia extract against multidrug-resistant klebsiella pneumoniae through niosome encapsulation

    , Article Nanomaterials ; Volume 11, Issue 6 , 2021 ; 20794991 (ISSN) Moghtaderi, M ; Mirzaie, A ; Zabet, N ; Moammeri, A ; Mansoori Kermani, A ; Akbarzadeh, I ; Eshrati Yeganeh, F ; Chitgarzadeh, A ; Bagheri Kashtali, A ; Ren, Q ; Sharif University of Technology
    MDPI AG  2021
    Abstract
    With the increased occurrence of antibiotic-resistant bacteria, alternatives to classical antibiotics are urgently needed for treatment of various infectious diseases. Medicinal plant extracts are among the promising candidates due to their bioactive components. The aim of this study was to prepare niosome-encapsulated Echinacea angustifolia extract and study its efficacy against multidrug-resistant Klebsiella pneumoniae strains. Encapsulation was first optimized by Design of Experiments, followed by the empirical study. The obtained niosomes were further charac-terized for the size and morphology using dynamic light scattering (DLS), transmission electron microscopy (TEM), and scanning... 

    Drug delivery and adhesion of magnetic nanoparticles coated nanoliposomes and microbubbles to atherosclerotic plaques under magnetic and ultrasound fields

    , Article Engineering Applications of Computational Fluid Mechanics ; Volume 15, Issue 1 , 2021 , Pages 1703-1725 ; 19942060 (ISSN) Alishiri, M ; Ebrahimi, S ; Shamloo, A ; Boroumand, A ; Mofrad, M. R. K ; Sharif University of Technology
    Taylor and Francis Ltd  2021
    Abstract
    The use of external fields such as magnet and ultrasound to enhance the targeted drug delivery (TDD) by nano-microcarriers could be a potential method. In this research, the drug delivery of magnetic nanoparticles (NPs) coated nanoliposomes and microbubbles (MBs) to the atherosclerosis plaque was investigated under magnetic and ultrasound fields in terms of their adhesion to the plaque through ligand–receptor binding. The Halbach arrangement enhanced the surface density of nanoliposomes and MBs adhered to the plaque by ∼ (Formula presented.) and ∼ (Formula presented.), respectively. A focused transducer at the power of (Formula presented.) led to better drug delivery performance and caused ∼... 

    Drug delivery and adhesion of magnetic nanoparticles coated nanoliposomes and microbubbles to atherosclerotic plaques under magnetic and ultrasound fields

    , Article Engineering Applications of Computational Fluid Mechanics ; Volume 15, Issue 1 , 2021 , Pages 1703-1725 ; 19942060 (ISSN) Alishiri, M ; Ebrahimi, S ; Shamloo, A ; Boroumand, A ; Mofrad, M. R. K ; Sharif University of Technology
    Taylor and Francis Ltd  2021
    Abstract
    The use of external fields such as magnet and ultrasound to enhance the targeted drug delivery (TDD) by nano-microcarriers could be a potential method. In this research, the drug delivery of magnetic nanoparticles (NPs) coated nanoliposomes and microbubbles (MBs) to the atherosclerosis plaque was investigated under magnetic and ultrasound fields in terms of their adhesion to the plaque through ligand–receptor binding. The Halbach arrangement enhanced the surface density of nanoliposomes and MBs adhered to the plaque by ∼ (Formula presented.) and ∼ (Formula presented.), respectively. A focused transducer at the power of (Formula presented.) led to better drug delivery performance and caused ∼... 

    Synthesis and characterization of N- diethyl methyl chitosan

    , Article Iranian Polymer Journal (English Edition) ; Volume 13, Issue 5 , 2004 , Pages 431-436+437 ; 10261265 (ISSN) Avadi, M. R ; Mahdavinia, G ; Sadeghi, A. M ; Erfan, M ; Amini, M ; Tehrani, M. R ; Shafiee, A ; Sharif University of Technology
    2004
    Abstract
    Biodegradable polymers such as chitosan have been used extensively in biomedical fields in the form of sutures; wound dressing and as artificial skin. Colonic drug delivery for either local or systemic effects has been the subject of much research over the last decade. Chitosan exhibits poor solubility at pH values above 6 that prevent enhancing effects at sites of absorption of drugs. In the present work, N-diethyl methyl chitosan (DEMC) was prepared based on a modified two-step process via a 22 factorial design to optimize the preparative conditions. DEMC Polymer with different degrees of quaternization for pharmacological and pharmaceutical experiments was achieved. The reaction was... 

    Curcumin delivery and co-delivery based on nanomaterials as an effective approach for cancer therapy

    , Article Journal of Drug Delivery Science and Technology ; Volume 78 , 2022 ; 17732247 (ISSN) Pourmadadi, M ; Abbasi, P ; Eshaghi, M. M ; Bakhshi, A ; Ezra Manicum, A. L ; Rahdar, A ; Pandey, S ; Jadoun, S ; Díez Pascual, A. M ; Sharif University of Technology
    Editions de Sante  2022
    Abstract
    Throughout the world, cancer is one of the main causes of mortality, threatening the public health in many countries. As a result, cancer therapy researchers are paying increasing attention to biocompatible targeted drug delivery systems. Nanocarriers and co-delivery of active drugs is emerging as an essential research field for improving therapeutic efficiency. Although nutraceuticals are now being used to prevent and treat chronic illnesses such as cancers, some have shown limitations concerning solubility, bioavailability, and biodegradability. This review explores different types of nanostructures that can be used as drug delivery systems for curcumin, a biologically active polyphenol... 

    Design of ionic liquids containing glucose and choline as drug carriers, finding the link between QM and MD studies

    , Article Scientific Reports ; Volume 12, Issue 1 , 2022 ; 20452322 (ISSN) Kalhor, S ; Fattahi, A ; Sharif University of Technology
    Nature Research  2022
    Abstract
    Designing drug delivery systems for therapeutic compounds whose receptors are located in the cytosol of cells is challenging as a bilayer cell membrane is negatively charged. The newly designed drug delivery systems should assist the mentioned drugs in passing the membrane barriers and achieving their targets. This study concentrated on developing novel ionic liquids (ILs) that interact effectively with cell membranes. These ILs are based on glucose-containing choline and are expected to be non-toxic. The binding energies of the known pharmaceutically active ionic liquids were calculated at the B3LYP/6-311++G(d,p) level in the gas phase and compared with those of our newly designed... 

    Nanotechnology-Abetted astaxanthin formulations in multimodel therapeutic and biomedical applications

    , Article Journal of Medicinal Chemistry ; Volume 65, Issue 1 , 2022 , Pages 2-36 ; 00222623 (ISSN) Jafari, Z ; Bigham, A ; Sadeghi, S ; Dehdashti, S. M ; Rabiee, N ; Abedivash, A ; Bagherzadeh, M ; Nasseri, B ; Karimi Maleh, H ; Sharifi, E ; Varma, R. S ; Makvandi, P ; Sharif University of Technology
    American Chemical Society  2022
    Abstract
    Astaxanthin (AXT) is one of the most important fat-soluble carotenoids that have abundant and diverse therapeutic applications namely in liver disease, cardiovascular disease, cancer treatment, protection of the nervous system, protection of the skin and eyes against UV radiation, and boosting the immune system. However, due to its intrinsic reactivity, it is chemically unstable, and therefore, the design and production processes for this compound need to be precisely formulated. Nanoencapsulation is widely applied to protect AXT against degradation during digestion and storage, thus improving its physicochemical properties and therapeutic effects. Nanocarriers are delivery systems with many...