Search for: glycosaminoglycans
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    A hybrid scaffold of gelatin glycosaminoglycan matrix and fibrin as a carrier of human corneal fibroblast cells

    , Article Materials Science and Engineering C ; Volume 118 , 2021 ; 09284931 (ISSN) Hajian Foroushani, Z ; Mahdavi salimi, S ; Abdekhodaie, M. J ; Baradaran Rafii, A ; Tabatabei, M. R ; Mehrvar, M ; Sharif University of Technology
    Elsevier Ltd  2021
    A hybrid scaffold of gelatin-glycosaminoglycan matrix and fibrin (FGG) has been synthesized to improve the mechanical properties, degradation time and cell response of fibrin-like scaffolds. The FGG scaffold was fabricated by optimizing some properties of fibrin-only gel and gelatin-glycosaminoglycan (GG) scaffolds. Mechanical analysis of optimized fibrin-only gel showed the Young module and tensile strength of up to 72 and 121 KPa, respectively. Significantly, the nine-fold increase in the Young modulus and a seven-fold increase in tensile strength was observed when fibrin reinforced with GG scaffold. Additionally, the results demonstrated that the degradation time of fibrin was enhanced... 

    GAG positioning on IL-1RI; A mechanism regulated by dual effect of glycosylation

    , Article Glycobiology ; Volume 29, Issue 11 , 2019 , Pages 803-812 ; 14602423 (ISSN) Azimzadeh Irani, M ; Ejtehadi, M. R ; Sharif University of Technology
    NLM (Medline)  2019
    IL-1RI is the signaling receptor for the IL-1 family of cytokines that are involved in establishment of the innate and acquired immune systems. Glycosylated extracellular (EC) domain of the IL-1RI binds to agonist such as IL-1β or antagonist ligands and the accessory protein to form the functional signaling complex. Dynamics and ligand binding of the IL-1RI is influenced by presence of the glycosaminoglycans (GAGs) of the EC matrix. Here a combination of molecular dockings and molecular dynamics simulations of the unglycosylated, partially N-glycosylated and fully N-glycosylated IL-1RI EC domain in the apo, GAG-bound and IL-1β-bound states were carried out to explain the co-occurring... 

    Fabrication of Fibrin Sheets for Tissue Regeneration

    , M.Sc. Thesis Sharif University of Technology Hajian Foroushani, Zahra (Author) ; Abdekhodaie, Mohammad Jafar (Supervisor)
    The cornea is a transparent, avascular, multilayer, connective tissue. When the erosion process of these cells occur, where natural and quick restoration is expected, corneal disorders begin. Regeneration of corneal tissue, using a biocompatible method is a great point of interest. Nowadays, scaffold based on amniotic membrane is used as a basement membrane in the regeneration of corneal tissue. Lots of researches focused on using auto graft scaffold to decrease the inflammation and infection of an allografts and synthetic scaffolds, while overcoming amniotic membrane’s weak mechanical properties. The aim of this survey is to construct an appropriate scaffold from patient’s own blood to...