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microcapsulation
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Design, Fabrication and Evaluation of Polymeric Microcapsules Containing Cells to Use in Cell Therapy in Heart
, M.Sc. Thesis Sharif University of Technology ; Mashayekhan, Shohreh (Supervisor) ; Sharifi, Ali Mohammad (Supervisor) ; Khanmohammadi, Mehdi (Co-Supervisor)
Abstract
Because of the inability of conventional methods to regenerate the infarcted part of the heart, regenerative medicine based on using scaffolds and hydrogels incorporation with cells and biological factors emerges as a promising approach. Micro-structures, especially hollow microcapsules created by the microfluidic system, has received a great deal of attention due to their inspired biomimetic structures, providing complete coverage cells, and preventing an immune response, consequently. This study aimed to use a microfluidic system to fabricate hollow microcapsules and investigate the behavior of rat cardiomyoblast cells (H9C2) along with exosomes within these structures. These structures'...
Adsorption Of Uranium from Phosphoric acid and Waste Water with Microcapsules Contains Selective Extractants
, M.Sc. Thesis Sharif University of Technology ; Ghofrani, Mohammad Bagher (Supervisor) ; Khanchi, Alireza (Supervisor) ; Outokesh, Mohammad (Co-Advisor)
Abstract
Uptake characteristics of alginate microcapsules containing D2EHPA/TOPO for adsorption of uranium from industrial effluent were examined using batch, stirred and column method .stable alginate microcapsules in dried form was developed by immobilizing of D2EHPA/TOPO in porous matrix of calcium alginate. Characteristics of microcapsules were carrying out by destructive chemical analysis, BET, SEM and TG .the synthesized microcapsules showed a good column properties and high selectivity and reusability. In addition, isotherm adsorption of calcium alginate and microcapsules were fitted with frendlich's equation .the microcapsules also demonstrated that, the uptake percentage was constantly high...
Folic Acid Microencapsulation
, M.Sc. Thesis Sharif University of Technology ; Alemzadeh, Iran (Supervisor)
Abstract
Most natural folate derivatives are highly sensitive to temperature, oxygen and light and their stability depends on food process condition. Alginate and pectin were evaluated for folic acid encapsulation and increasing its stability. By combining them and optimising encapsulation condition the efficiency was enhanced up to 90% . Furthermore, using polymers in combined form caused decrease in folic acid leakage from capsules in acidic condition of stomach. First of all, the time of encapsulation was measured which was 140-180 minutes. In this study the effect of Calcium Chloride concentration on encapsulation was studied. Therefore, two variables were selected which were pectin to algine...
Synthesis and characterization of new biopolymeric microcapsules containing DEHPA-TOPO extractants for separation of uranium from phosphoric acid solutions
, Article Journal of Microencapsulation ; Volume 28, Issue 4 , 2011 , Pages 248-257 ; 02652048 (ISSN) ; Tayyebi, A ; Khanchi, A ; Grayeli, F ; Bagheri, G ; Sharif University of Technology
Abstract
A novel microcapsule adsorbent for separation of uranium from phosphoric acid solutions was developed by immobilizing the di(2-ethylhexyl) phosphoric acid-trioctyl phosphine oxide extractants in the polymeric matrix of calcium alginate. Physical characterization of the microcapsules was accomplished by scanning electron microscopy and thermogravimetric techniques. Equilibrium experiments revealed that both ion exchange and solvent extraction mechanisms were involved in the adsorption of ions, but the latter prevailed in a wider range of acid concentration. According to the results of kinetics study, at low acidity level, the rate controlling step was slow chemical reaction of ions with the...
Hydrothermal Synthesis of Copper (II) Oxide Nanparticles at Supercritical Conditions and Their Application in Decantamination of Tritium Polluted Streams
, M.Sc. Thesis Sharif University of Technology ; Ghofrani, Mohammad Bagher (Supervisor) ; Ahmadi, Javad (Supervisor) ; Outokesh, Mohammad (Co-Advisor) ; Mosavand, Tahereh (Co-Advisor)Investigation on Insulin Release from Microcapsules Containing Beta Cell
, M.Sc. Thesis Sharif University of Technology ; Alemzadeh, Iran (Supervisor) ; Vossoughi, Manouchehr (Supervisor)
Abstract
Type 1 diabetes, formerly known as insulin-dependent diabetes, may present at any age, but is the most common type of diabetes affecting children and adolescents. People with type 1 diabetes do not produce enough insulin. This type accounts for 5-10% of all types of diabetes. In this type of diabetes, beta cell destruction occurs in the pancreas. In type 1 diabetes, the pancreas does not secrete any insulin; insulin is a hormone that enables the body to convert glucose in food into energy. If sugar in the blood cannot enter the cells, it accumulates in the arteries and results in high blood sugar. High blood sugar over time can have irreversible effects on various parts of the body. Curcumin...
Comparison of the batch and breakthrough properties of stable and plain alginate microcapsules with a chelating resin and an ion exchanger in Ag+ adsorption
, Article Industrial and Engineering Chemistry Research ; Volume 47, Issue 17 , 5 August , 2008 , Pages 6742-6752 ; 08885885 (ISSN) ; Niibori, Y ; Mimura, H ; Ahmadi, S. J ; Sharif University of Technology
2008
Abstract
A comparative study on the uptake properties of alginate microcapsules containing Cyanex 302 extractant, Lewatite TP 214 chelating resin, and Amberlite 200CT strongly acidic ion exchanger has been conducted using Ag+ as the target ion. The study resulted in an analytical formula, as well as three phenomenological breakthrough formulas that are also applicable in other fixed-bed operations. It also demonstrated a close similarity of the uptake properties of alginate microcapsules (MCs) and the chelating resins. Advantages of MCs over chelating resins include ease of preparation, ability to immobilize different extractants, and, most remarkably, an enormous distribution factor (Kd ≈ 106...
Simulation of Microcapsule Formation for Cell Encapsulation Application
, M.Sc. Thesis Sharif University of Technology ; Saeedi, Mohammad Saeed (Supervisor) ; Kazemzadeh Hanani, Siamak (Co-Advisor)
Abstract
Co-culture of different cells is necessary for cancer spheroid formation in preclinical drug tests. It is possible to produce thousands of micro-droplets containing different cells, i.e. microcapsules, in a short time, using droplet microfluidics. However the homogeneity of the cell numbers in the droplets has remained as an unsolved problem.Despite the large amount of experimental efforts to reduce the number of undesirable microcapsules, no one tried to utilize the ease of computer aided simulation for investigating different parameters. In this study, we develop a novel method for capturing cell encapsulation using CFD simulations. The effect of the cell suspension inhomogeneity and...
The application of corrugated parallel bundle model to immobilized cells in porous microcapsule membranes
, Article Journal of Membrane Science ; Volume 311, Issue 1-2 , 2008 , Pages 159-164 ; 03767388 (ISSN) ; Zarrabi, A ; Khosravi, A ; Sharif University of Technology
2008
Abstract
To describe immobilized cells in porous microcapsule membranes with straight pores, a novel model called corrugated parallel bundle model (CPBM) was utilized. In this model, a network was developed with 10 main pores each composing 10 pore elements. Cell growth kinetic in the network was examined using non-structural models. Effectiveness factor and pore plugging time were calculated by solving reaction-diffusion equation set via finite difference method. The findings revealed that diffusion coefficient for lower order reactions will create a lesser impact on the reduction of effectiveness factor. These findings also indicated that the use of such supporting carrier for cell immobilization...
Breakup of microdroplets in asymmetric T junctions
, Article Physical Review E - Statistical, Nonlinear, and Soft Matter Physics ; Volume 87, Issue 5 , 2013 ; 15393755 (ISSN) ; Salari, A ; Shafii, M. B ; Sharif University of Technology
2013
Abstract
Symmetric T junctions have been used widely in microfluidics to generate equal-sized microdroplets, which are applicable in drug delivery systems. A newly proposed method for generating unequal-sized microdroplets at a T junction is investigated theoretically and experimentally. Asymmetric T junctions with branches of identical lengths and different cross sections are utilized for this aim. An equation for the critical breakup of droplets at asymmetric T junctions and one for determining the breakup point of droplets are developed. A good agreement was observed between the theories (present and previous) and the experiments
Optimization of alginate-whey protein isolate microcapsules for survivability and release behavior of probiotic bacteria
, Article Applied Biochemistry and Biotechnology ; Volume 190, Issue 1 , 2020 , Pages 182-196 ; Alemzadeh, I ; Vaziri, A. S ; Vossoughi, A ; Sharif University of Technology
Springer
2020
Abstract
The present study aimed to improve the survivability of L. acidophilus encapsulated in alginate-whey protein isolate (AL-WPI) biocomposite under simulated gastric juice (SGJ) and simulated intestinal juice (SIJ). Microcapsules were prepared based on emulsification/internal gelation technique. Optimal compositions of AL and WPI and their ratio in the aqueous phase were evaluated based on minimizing mean diameter (MD) of the microcapsules and maximizing encapsulation efficiency (EE), survivability of cells under SGJ (Viability), and release of viable cells under SIJ (Release) using Box-Behnken experimental design. Optimal composition comprising 4.54% (w/v) AL, 10% (w/v) WPI, and 10% (v/v)...