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Investigation of Biocompatibility and Biodegradability of Porous Chitosan Scaffold in Nerve Tissue Engineering
, M.Sc. Thesis Sharif University of Technology ; Mashayekhan, Shohreh (Supervisor) ; Ramezani Saadat, Ahmad (Supervisor)
Abstract
Nerve repair plays a very prominent and significant role among the efforts that have been made to integrate the concepts of tissue engineering in strategies to repair almost all parts of the body. This is partly due to the complexity of the nervous anatomy system and its function as well as the inefficiency of conventional repair methods that are based on a component of biomaterials or cells alone. Studies show that electrical stimulation can enhance the nerve regeneration process; so the use of conducting polymers has attracted much attention for the construction of neural tissue engineering scaffolds. In this study, the electrical properties of neurons and the effects of electrical...
Design and Fabrication of Conductive Polymeric Nanocomposite Scaffolds for Nerve Tissue Engineering
, Ph.D. Dissertation Sharif University of Technology ; Ramezani Saadat, Ahmad (Supervisor)
Abstract
In the current study, design, fabrication, and characterization of a novel conductive nanocomposite scaffold for nerve tissue engineering applications is reported. For this purpose, the highly conductive polyaniline/graphene nanocomposite (PAG) was synthesized via emulsion polymerization, used for fabrication of conductive chitosan/gelatin/PAG scaffolds, and the effect of PAG amount on the various properties of scaffolds were investigated. The synthesized graphene, polyaniline, and PAG were characterized and the obtained results revealed that partially exfoliated graphene nanosheets and highly conductive PAG with a conductivity of about 12 S.cm-1 and 7 S.cm-1, respectively were obtained. The...
Fabrication and characterization of conductive chitosan/gelatin-based scaffolds for nerve tissue engineering
, Article International Journal of Biological Macromolecules ; Volume 74 , 2015 , Pages 360-366 ; 01418130 (ISSN) ; Ramazani S. A., A ; Mashayekhan, S ; Sharif University of Technology
Abstract
This paper reports on the development of conductive porous scaffolds by incorporating conductive polyaniline/graphene (PAG) nanoparticles into a chitosan/gelatin matrix for its potential application in peripheral nerve regeneration. The effect of PAG content on the various properties of the scaffold is investigated and the results showed that the electrical conductivity and mechanical properties increased proportional to the increase in the PAG loading, while the porosity, swelling ratio and in vitro biodegradability decreased. In addition, the biocompatibility was evaluated by assessing the adhesion and proliferation of Schwann cells on the prepared scaffolds using SEM and MTT assay,...