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Study and Preparation of Coated Drug by PEG Biopolymer (PEGylation) for Release Controlling

Tavakoli Naeini, Ashkan | 2009

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 39162 (06)
  4. University: Sharif University of Technology
  5. Department: Chemical and Petroleum Engineering
  6. Advisor(s): Vossoughi, Manoochehr; Sarbolouki, Mohammad Nabi
  7. Abstract:
  8. In the first part of this work, citric acid monomer was selected to produce dendrimer through the divergent method using logical conditions (for controlling its functional groups) on the base of poly (ethylene glycol) as the core. Triblock copolymers (ABA-type) of citric acid and poly (ethylene glycol) (PCA-PEG-PCA) as biocompatible compounds were synthesized in four different molecular weights and applied as nanocarriers. The structure definition of the molecules and nanoparticles were carried out using different spectroscopy methods. Diameter of the synthesized copolymers was investigated using dynamic light scattering (DLS) experiments and transmission electron microscopy (TEM) and it was between 1.8 and 2.2 nm for the four different molecular weights. These linear-dendritic copolymers are soluble in water and due to the end acidic functional groups of citric acid, form the hydrogel in aqueous solutions. These nanocarriers were used as the nanocarrier agents in which some of nanoparticles are entrapped. In the second part, gold nanoparticles were encapsulated within the above-synthesized linear-dendritic copolymers. Protected metal nanoparticles by PCA-PEG-PCA were stable in water for several months and agglomeration was not occurred. Transport capacities of these copolymers were investigated. The size of gold nanoparticles and also reducing ability and loading capacity of these linear–dendritic nanocarriers were investigated within a simultaneously reduction reaction of the HAuCl4 and encapsulation of gold nanoparticles by using UV-visible spectroscopy and TEM. It was found that the loading capacity of PCA-PEG-PCA macromolecules directly depends on the size of dendritic citric acid parts whereas there is a reverse relationship between the size of synthesized nanoparticles and this parameter
  9. Keywords:
  10. Polyethylen Glycol (PEG) ; Gold Nanoparticle ; Citric Acid ; CONTROLLED RELEASE ; Linear-Dendritic Copolymer ; Loading Capacity

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