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- Type of Document: M.Sc. Thesis
- Language: Farsi
- Document No: 41003 (03)
- University: Sharif University of Technology
- Department: Chemistry
- Advisor(s): Matloubi Moghaddam, Firouz
- Abstract:
- Stachys species have played crucial role as a folk-medicinal plants since so many years ago. According to their commercial interest in the production of essential oils and flavoring agents, investigation through their secondary metabolisms still has been done. In the first part of this research, we have done our phytochemical investigation of Stachys inflata. The aerial parts of this plant have been collected; we could isolate and identify 5 molecules. Their structural elucidation was accomplished by extensive spectroscopic methods including 1H NMR, 13C NMR and 13C Dept experiments. In the second part of the research, we have reported a new and efficient synthesis of a broad spectrum of heterotetracyclic benzoxazocines via unique tandem 1,3-dinucleophilic addition of different bifunctional nucleophiles to quinolinium and isoquinolinium salts. The reaction generally involves the initial addition of nucleophiles to quinolinium salts to form enamine intermediate which can be trapped by intramolecular O/S-alkylation of nucleophiles. In the third part, as continues of the second part, we have reported another method which is consist of Anthocyanidins and Thioindoles by using water and acetic acid as the solvent. This protocol is a very mild and simple method for construction of eight-membered ring in fused heterocycles in a one-step process.
- Keywords:
- Extract ; Flavonoids ; Spearmint ; Quinolinium Salt ; Stachys Inflata ; Anthocyanidin
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