Fabrication and Characterization of  PVA/PLA Composites

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Behnoudfar, Diba | 2010

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Type of Document: M.Sc. Thesis
Language: Farsi
Document No: 41009 (06)
University: Sharif University of Technology
Department: Chemical and Petroleum Engineering
Advisor(s): Frounchi, Masoud; Dadbin, Susan
Abstract:
Poly (vinyl alcohol) (PVA) hydrogel is a biocompatible material, which has been widely applied in drug delivery applications. Microspheres, nanospheres, and other types of particle-based drug delivery vehicles have proven capacity for long-term release. There is growing interest to overcoming the inherent pharmacological limitations of hydrogels by formulating particulate systems into the hydrogel matrix to form new delivery platforms. We here describe a simple composite system based on poly (vinyl alcohol) (PVA) hydrogels containing entrapped drug-loaded poly (lactic acid) (PLA) microspheres for controlled delivery over extended period of time. Gamma-Irradiation and freeze-thawing was applied to prepare poly (vinyl alcohol) hydrogels. The properties of these hydrogels were investigated and compared. In vitro release indicated that entrapment of the microspheres into the PVA hydrogels causes a reduction in both the release rate and the total amount of drug released, which suggesting that PLA microspheres entrapped into the PVA hydrogels showed more suitable controlled release kinetics for drug delivery.
Keywords:
Hydrogel ; Polylactic Acid ; Poly Vinyl Alcohol ; Drug Delivery ; CONTROLLED RELEASE ; Microspheres

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