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Manufacturing and Characterization of Bone Scaffold Based on TCP

Gorgin Karaji, Zahra | 2010

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 41169 (07)
  4. University: Sharif University of Technology
  5. Department: Materials Science and Engineering
  6. Advisor(s): Bagheri, Reza
  7. Abstract:
  8. Bone scaffolds are combinations of several materials, for achieving suitable properties and usage for replacing with defected bone. In this study, TCP/Agarose scaffolds are fabricated by two different approaches. The first one is using polymer sponge and gel casting technique and the other one is using foaming agent in order to obtain scaffolds with same porosity. The results show that in spite of same structure and porosity, scaffolds have different mechanical properties due to their different morphologies. Compressive strength of the scaffolds which were fabricated using polymer sponge method is 2.25MPa and elastic modulus is 56.8MPa. After coating with Agarose, compressive strength becomes 3.03MPa. Hence coating scaffolds with Agarose increases compressive strength 1.33 times, whereas it hasn’t any significant effect on the elastic modulus. Compressive strength of the scaffolds prepared using foaming agent method is 4.9MPa which is 2.17 times more than compressive strength of the scaffolds fabricated using polymer sponge/ gel casting technique. Elastic modulus of the scaffolds prepared using foaming agent is 206.57MPa which is 3.64 times more than the scaffolds fabricated using polymer sponge/ gel casting technique. After coating this kind of scaffolds with Agarose their compressive strength becomes 5.62MPa. Consequently coating with Agarose increases compressive strength 1.14 times, whereas it has not any considerable effect on the elastic modulus same as modulus in using polymer sponge/ gel casting technique. Furthermore, soaking scaffolds in SBF for 3 weeks caused calcium phosphate precipitations on the scaffolds. These precipitations are further on the areas with rougher surface. Precipitate calcium phosphate result in increasing weight and compressive strength of scaffolds after soaking in SBF in every four types of scaffolds
  9. Keywords:
  10. Mechanical Properties ; Simulated Body Fluid (SBF) ; Tissue Engineering ; Bone Scaffold ; TCP/Agarose Composite

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