Simulation of a Simple Model of Endothelial Cell Using Dissipative Particle Dynamics Method

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Kiyoumarsi Oskouei, Amir | 2011

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Type of Document: M.Sc. Thesis
Language: Farsi
Document No: 42988 (08)
University: Sharif University of Technology
Department: Mechanical Engineering
Advisor(s): Saeedi, Mohammad Saeed; Firoozabadi, Bahar
Abstract:
Endothelium is the interior layer of an artery made up of tremendous number of endothelial cells which are located side by side. Finding the effective parameters that cause the cells to obtain mechanical strength in different morphologies is a major effort in cell engineering studies. In this work a numerical model for endothelial cells is developed. This model has included cell's plasma membrane (the outer membrane of the cell), nucleus and cytoskeleton main components including intermediate and actin filaments as well as microtubules. The model has been validated by simulating the adhesion of the cells to a flat substrate and also atomic force microscopy (AFM) experiments. The two most popular morphologies of the cells resulted from this work are the cell suspension morphology which is the result of no external forces and the cell adherent morphology which is the result of cell adhesion to the extracellular matrix. These two geometries will be helpful in the simulation of other biological processes and modeling other vital and biological mechanisms
Keywords:
Cell Adhesion ; Atomic Force Microscopy (AFM) ; Dissipative Particle Dynamics (DPD) ; Cell Suspension ; Cytoskeleton ; Cell Membrane ; Endothelial Cell

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