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Modeling, Simulation and Characterization of Pressurized Reservoir Insulin Pump

Alipour, Davoud | 2012

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  1. Type of Document: M.Sc. Thesis
  2. Language: English
  3. Document No: 43510 (58)
  4. University: Sharif University of Technology
  5. Department: Science and Engineering
  6. Advisor(s): Saidi, Mohammad Said; Sani, Mahdi
  7. Abstract:
  8. Insulin pump treatment is considered the most physiological way to imitate the healthy body's insulin profile in patients with diabetes. They provide a precisely controlled rate of insulin delivery to diabetic patients who would normally need multiple daily injections to regulate blood glucose levels. The firmware allows numerous modifications to the bolus dose and basal rate to enable patients to manage insulin levels in response to events such as eating, sleeping, and exercise.
    In this Study, we have first investigated different models of insulin pumps on the market and chose the Spring ZoneTM insulin pump model for our study due to its innovative technology. This pump employs a pressurized reservoir of liquid medicament with controlled release via a flow restriction and multiple valves. Then openly available documents related to the pump, including patents and catalogs have been studied to better understand the pump behavior and make a 3D CAD model of the pump cartridge which is used in simulations.
    The main purpose of this study is to simulate the injection process using the finite element method. Commercially available code ANSYS CFX is used for simulation. In the present study, a fluid-structure interaction (FSI) analysis is performed to characterize measurement and control of the mechanism which is used to provide defined dosage of insulin. This insulin is delivered to the outlet through the micro-hydraulic circuit of the pump cartridge which was also simulated.

    Finally, in order to verify the simulation, an experimental model is also built. The experimental setup was simulated in ANSYS CFX. With some considerations, numerical results are in good agreement to the experimental ones.
  9. Keywords:
  10. Fluid-Structure Interaction ; Insulin Pump ; Continuous Subcutaneous ; Drug Delivery Device ; Pressurized Reservoir Pump

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