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- Type of Document: M.Sc. Thesis
- Language: Farsi
- Document No: 43822 (06)
- University: Sharif University of Technology
- Department: Chemical and Petroleum Engineering
- Advisor(s): Abdekhodaie, Mohammad Jafar; Farhadi, Fatollah
- Abstract:
- In this study a mathematical model for intravitreal injection and depositing controlled release systems in the eye to treat posterior segment deseases is developed. The effects of important parameters that play a critical role in drug distribution are also studied.
Geometrical model is constructed using COMSOL software and governing equations for a 3-D model of drug distribution are solved by finite element method. The geometry is based on the exact dimensions of human eye and retina, choroid and sclera are considered separately. Choroidal losses to the circulatory system and active transport by the retinal pigment epithelium are incorporated as well. Moreover, two types of implant (Iluvien & Vitrasert) are placed in different parts and concentration profiles are presented. For simulating intravitreal injection, the shape of drug solution immediately after injection is analyzed and the concentration at this site is set equal to the desired concentration as initial condition.
The results show that the implant location has a significant effect on drug distribution. Trans-scleral delivery is the less efficient mode of drug delivery to the posterior segment because of three types of barriers hindering drug transport. However, as this method is less invasive it has been the most practiced. Injection time, needle gauge and needle angle dramatically affect the local concentrations. Optimal selection of controlled release systems location and identifying conditions that affect intravitreal drug delivery could reduce side effects and possibility of retinal toxicity caused by high doses of drug - Keywords:
- Mathematical Modeling ; Drug Delivery ; CONTROLLED RELEASE ; Intraocular ; Eye Posterior Segment
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