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Mechanical Behavior Analysis of Biological Cells Using an Electrostatically Actuated Microbeam

Esmaeilpour Charandabi, Sina | 2013

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 44776 (08)
  4. University: Sharif University of Technology
  5. Department: Mechanical Engineering
  6. Advisor(s): Firoozbakhsh, Keikhosrow
  7. Abstract:
  8. Researches in last decades have shown that biological cell’s functionality is related to the way of their deformation in response to forces and stresses exerted on the cell. Therefore designing microsensors with easy and economical applicationswhich are capable for determining cell mechanical properties seems to be logical. In this project using an electrostatically actuated microbeam with both clamped ends equipped with an indenter at midpoint to transmit force on the cell, proposed as a technique to apply axial load on the cell. Inthis research by implementation of approximated methods for solving nonlinear algebraic and differential equations, governing on microbeam deflection, it has been tried to introduce closed-form relations describing the cell mechanical behavior. By this way determining mechanical properties of the cell would be feasible. In order to have results more adopted with real application conditions of the system, the effects of fringing field and squeeze film damping have been considered in static and dynamic analysis of the microbeam and the governing equation on viscoelastic cell model has derivedas well. Thecontributionof each element as well as theprecision of microbeam reduced order model in predecting reaction force for three different cells with respect to indenter displacement, have been analyzed
  9. Keywords:
  10. Electrostatic Actuation ; Cell Indentation ; Fringing Field ; Squeeze Film Damping ; Mode-Summation Method ; Multi-Scale Analysis

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