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Targeted Delivery of Curcumin by Mesoporous Silica Nanoparticle Coated with Liposome

Hedayati, Mohammad Hassan | 2014

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 46246 (06)
  4. University: Sharif University of Technology
  5. Department: Chemical and Petroleum Engineering
  6. Advisor(s): Abdekhodaie, Mohammad Jafar; Akbari, Hamid
  7. Abstract:
  8. Several studies based on anti- cancer, anti- metastatic and anti- tumor effects of curcumin have been reported . Besides these benefits, the therapeutic efficacy of curcumin is limited due to its poor aqueous solubility, extensive first-pass metabolism, inadequate tissue absorption and degradation at alkaline pH, which severely diminishes its bioavailability. In this project we seek to solve some of the problems with nanoscience to work more effectively. In the past decade, mesoporous silica nanoparticles (MSNs) have found widespread application as controlled drug delivery systems. Recent reports on the design of capped and gated MSN-based systems have shown promise in preventing premature release of drug and controlled release of guest molecules from MSNs.
    In the present work we report on the fabrication of folate conjugated chitosan indirectly- wrapped onto MSN. Indeed, we coated a layer of liposome on the surface of MSN loaded with curcumin and then targeted it with wrapping FA–CS conjugates. We believe that the role of liposome is to increase the sensitivity of nanoparticle in the different pH medium.
    We investigate its in vitro release experiments which are conducted under pH 5.5 and 7.4 buffer solutions. To the best of our knowledge, this is the first time to wrap FA–CS conjugates outside MSN and to be applied in controlling the amount of released drugs at near neutral pH environment.
  9. Keywords:
  10. Liposoms ; Anticancer Drugs ; Curcumin ; Mesoporous Silica Nanoparticles ; Targeted Druy Delivery

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