Loading...

Numerical Modeling of Blood Coagulation in Stenosis

Kord, Ali | 2015

2679 Viewed
  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 46806 (08)
  4. University: Sharif University of Technology
  5. Department: Mechanical Engineering
  6. Advisor(s): Taghizadeh Manzari, Mehrdad; Shamloo, Amir
  7. Abstract:
  8. Trombosis formation in blood flow is a complex biochemical and very important process for body health which impedes blood loss by creating obstacles in the path of injured wall vessels. Although this phenomenon plays a very significant role in healthy body function, unfortunately it has been observed that it could cause diseases or even stroke. The reason is that thrombosis formation in blood and its detachment from the vessel wall can result in block body capillaries and lead a catastrophic event for the body. One of the factors which motivates blood for forming unnatural thrombosis is the vessel stenosis. It would ange in normal blood flow path and cause thrombosis formation as time is going on. The reason for this phenomenon is that the platelets existing in the blood flow play the main role in thrombosis formation and it has been observed that by applying special shear rates and in the basis of the applying time, platelets are activated and result in thrombosis formation. Among the platelets, two proteins of Fibrinogen and von Willebrand factor (vWf) also have significant role in platelet-platelet or platelet-vessel wall attachment. No matter what factors lead to stenosis, this project focuses on thrombosis formation phenomenon on these biophysical conditions and by a two-dimensional method. The numerical method of Smoothed Particle Hydrodynamics (SPH) is used for simulating blood flow, platelet movements, and thrombosis process. Probability functions whi are based upon protein type, Fibrinogen and vWF, and are related to time and shear rate values and are extracted from experimental results are used for thrombosis modelling. By using platelet movements in blood flow and the mentiond probability functions, the thrombosis formation in different stenosis types is simulated
  9. Keywords:
  10. Blood Flow ; Smoothed Particle Hydrodynamics (SPH) ; Thrombosis Formation ; Stenosis

 Digital Object List

 Bookmark

...see more