Loading...
| Friend's email | |
| Your name | |
| Your email | |
| enter code | |
This page was sent successfuly
Functionalized mesoporous silica-coated magnetic graphene oxide by polyglycerol-g-polycaprolactone with pH-responsive behavior: designed for targeted and controlled doxorubicin delivery
Pourjavadi, A ; Sharif University of Technology
972
Viewed
- Type of Document: Article
- DOI: 10.1016/j.jiec.2015.01.021
- Abstract:
- In the present work a novel multifunctional drug nanocarrier was prepared. Polyglycerol-. g-polycaprolactone was grafted on Mesoporous silica-coated magnetic graphene oxide. Doxorubicin, as anticancer drug, was loaded on this carrier. The in vitro drug release showed the controlled pH responsive behavior. At the endosomal pH (pH 5.5) the amount of drug release enhanced. This nanocarrier would have potential application in the tumor therapy owing to its biodegradability, controlled release and pH responsive behavior
- Keywords:
- Magnetic graphene oxide ; Polyglycerol ; Biodegradation ; Graphene ; Polycaprolactone ; Silica ; Anticancer drug ; Controlled release ; Doxorubicin ; Functionalized ; Graphene oxides ; Mesoporous silica ; Polyglycerols ; Tumor therapy ; Mesoporous materials
- Source: Journal of Industrial and Engineering Chemistry ; 2015 ; ISSN: 1226086X
- URL: http://www.sciencedirect.com/science/article/pii/S1226086X15000313