Granisetron Transdermal Drug Delivery System

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Dehbini, Hamid Reza | 2015

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Type of Document: M.Sc. Thesis
Language: Farsi
Document No: 47139 (06)
University: Sharif University of Technology
Department: Chemical and Petroleum Engineering
Advisor(s): Abdekhodaie, Mohammad Jafar; Taghizadeh, Mojtaba
Abstract:
Transdermal drug delivery systems are products which are known to have ability to pass drugs through the skin and into the blood, so medicine effects appear as a result. During the past two decades, many scientists interested in drug delivery through the skin. Constant blood plasma level and avoiding first-pass metabolism are advantages of this system compared to oral and intravenous systems. The biggest problem in the development of these systems, is impermeability of Stratum corneum, the outermost layer of the epidermis. In this study, design and evaluation of in vitro transdermal drug delivery system for granisetron serve as treatment of nausea and vomiting was performed. For this purpose, different formulations based on Acrylic and PIB PSAs and different additives were used. These formulations obtained from fractional factorial design and prepared and evaluated. Isopropyl myristate and methylpyrrolidone were used as chemical enhancers and polyvinylpyrrolidone was used as anti-crystallization. The effects of these variables on the cumulative amount of drug released and adhesion properties were evaluated
Keywords:
Transdermal Drug Delivery System ; Skin Permeation ; Adhesion ; Granisetron