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Anomalous diffusion of proteins in sheared lipid membranes

Khoshnood, A ; Sharif University of Technology | 2013

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  1. Type of Document: Article
  2. DOI: 10.1103/PhysRevE.88.032705
  3. Publisher: 2013
  4. Abstract:
  5. We use coarse grained molecular dynamics simulations to investigate diffusion properties of sheared lipid membranes with embedded transmembrane proteins. In membranes without proteins, we find normal in-plane diffusion of lipids in all flow conditions. Protein embedded membranes behave quite differently: by imposing a simple shear flow and sliding the monolayers of the membrane over each other, the motion of protein clusters becomes strongly superdiffusive in the shear direction. In such a circumstance, the subdiffusion regime is predominant perpendicular to the flow. We show that superdiffusion is a result of accelerated chaotic motions of protein-lipid complexes within the membrane voids, which are generated by hydrophobic mismatch or the transport of lipids by proteins
  6. Keywords:
  7. Anomalous diffusion ; Coarse-grained molecular dynamics simulations ; Diffusion properties ; Hydrophobic mismatch ; In-plane diffusion ; Protein clusters ; Simple shear flow ; Trans-membrane proteins ; Lipids ; Molecular dynamics ; Proteins
  8. Source: Physical Review E - Statistical, Nonlinear, and Soft Matter Physics ; Volume 88, Issue 3 , September , 2013 ; 15393755 (ISSN)
  9. URL: http://journals.aps.org/pre/abstract/10.1103/PhysRevE.88.032705