Colorimetric Determination of Tizanidine and Mercury (II) Based on Aggregation and Anti-aggregation of Gold Nanoparticles

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Yahyazadeh, Ehsan | 2015

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Type of Document: M.Sc. Thesis
Language: Farsi
Document No: 47480 (03)
University: Sharif University of Technology
Department: Chemistry
Advisor(s): Hormozi Nezhad, Mohammad Reza
Abstract:
In the first section of this research, we have developed a simple and rapid colorimetric method for determination of tizanidine using citrate capped gold nanoparticles. Under optimal conditions, the AuNPs easily aggregate upon addition of tizanidine and the solution color changes from red to gray. This color change was followed using a UV-Vis spectrophotometer. The detection limit was calculated to be 0.48 µM. The method was successfully applied for determination of tizanidine in Spalex© tablets. In the last section, the anti-aggregation effect of Hg(II) on the tizanidine-AuNPs system was utilized with the aim of developing a colorimetric method for detection of Hg(II). Addition of tizanidine to the AuNPs solution induces a color change from red to gray. In the presence of mercury(II), intensity of such a color change decreases. This decrease in color change was followed as the analytical signal. Under optimal conditions, the sensor's limit of detection (LOD) was found to be 29 nM. This method was successfully applied for detection of Hg(II) in mineral and tap water samples
Keywords:
Gold Nanoparticle ; Association ; Anti-Windup ; Mercury ; Colorimetric Determination ; Colorimetric Sensor ; Tizanidine

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