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- Type of Document: M.Sc. Thesis
- Language: Farsi
- Document No: 48507 (06)
- University: Sharif University of Technology
- Department: Chemical and Petroleum Engineering
- Advisor(s): Bastani, Dariush; Mashayekhan, Shohreh
- Abstract:
- This research studies a 3D channeled myocardium scaffold with computational fluid dynamics. It proposes a mathematical model to evaluate the impact of oxygen carriers and scaffold geometry on cell growth in a 3D cardiac construct. The modeling results show that using 5.4% perfluorocarbon oxygen carrier (PFC) has increased cardiac cells density 15% of the initial seeded cells comparing to pure culture medium without PFC supplementation. Effects of the scaffold geometry on cell density in the construct were examined by increasing channel numbers and changing the construct length. The results show that increasing channel numbers (by 50% decreasing channels diameter and wall to wall spacing) the average cells density increase 8.1% of the initial seeded cells density. Furthermore, the average cell density has been increased 6.3% of the initial seeded cells by decreasing 0.3 cm of the length of scaffold.The obtained results from the simulation were in good agreement with the experimental data of oxygen concentration distribution along the length of the channeled tissue construct and experimental data of cell density in the scaffold after cultivation of cardiac myocytes for 3 days in this channeled construct
- Keywords:
- Simulation ; Scaffold ; Diffusion ; Hydrodynamics ; Scaffold
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