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An efficient one-pot synthesis of tri-substituted thiophenes via a multicomponent reaction in water

Matloubi Moghaddam, F ; Sharif University of Technology | 2010

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  1. Type of Document: Article
  2. DOI: 10.1080/17415993.2010.496129
  3. Publisher: 2010
  4. Abstract:
  5. An efficient one-pot synthesis of functionalized trisubstituted thiophenes via the reaction of 3-morpholino-3-thioxopropanenitrile, cyclohexyl isocyanide and -haloketones is reported. This method provides a straightforward route to a variety of highly substituted thiophenes not easily accessible by conventional methods
  6. Keywords:
  7. Amides ; Cyclization ; Multicomponent reaction ; Nitriles ; Thiophene
  8. Source: Journal of Sulfur Chemistry ; Volume 31, Issue 5 , May , 2010 , Pages 387-393 ; 17415993 (ISSN)
  9. URL: http://www.tandfonline.com/doi/abs/10.1080/17415993.2010.496129