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Mesoporous silica nanoparticles with bilayer coating of poly(acrylic acid-co-itaconic acid) and human serum albumin (HSA): A pH-sensitive carrier for gemcitabine delivery

Pourjavadi, A ; Sharif University of Technology

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  1. Type of Document: Article
  2. DOI: 10.1016/j.msec.2015.12.096
  3. Abstract:
  4. Novel bilayer coated mesoporous silica nanoparticle (MCM-41) based on pH sensitive poly(acrylic acid-co-itaconic acid) and human serum albumin (HSA) was designed for controlled delivery of gemcitabine (anticancer drug) to cancer cells. The shell around the mesoporous silica has bilayer structure. Poly(acrylic acid-co-itaconic acid) was used as pH-sensitive inner shell and human serum albumin, HSA, was used as outer shell. The core-shell structure was formed due to electrostatic interaction between ammonium groups of modified MCM-41 and carboxylate groups of copolymer. Also, the albumin layer was wrapped around the copolymer coated nanoparticle by electrostatic interaction between ammonium groups from protein and carboxylate ions of copolymer shell. Moreover, the maximum release occurred at pH 5.5 (pH of endosomes) because the bilayer shell collapsed at this pH. The drug nanocarrier would be a good candidate for tumor therapy due to its biocompatibility, controlled release and pH responsive behavior
  5. Keywords:
  6. Human serum albumin ; Mesoporous silica nanoparticle ; pH-sensitive carrier ; Poly(acrylic acid-co-itaconic acid) ; Acrylics ; Biocompatibility ; Body fluids ; Carboxylation ; Carboxylic acids ; Controlled drug delivery ; Electrostatic separators ; Electrostatics ; Nanoparticles ; Organic acids ; pH sensors ; Plastic coatings ; Shells (structures) ; Silica ; Coated nanoparticles ; Controlled delivery ; Controlled release ; Core shell structure ; Human serum albumins ; Itaconic acid ; Mesoporous silica nanoparticles ; pH sensitive ; Mesoporous materials
  7. Source: Materials Science and Engineering C ; Volume 61 , 2016 , Pages 782-790 ; 09284931 (ISSN)
  8. URL: http://www.sciencedirect.com/science/article/pii/S0928493115307074