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The feasibility Study on Magnetic Resonance Spectroscopy (MRS) Thermometry in the Presence of Magnetic Field Inhomogeneity

Taghavi, Marziyeh | 2017

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 49526 (46)
  4. University: Sharif University of Technology
  5. Department: Energy Engineering
  6. Advisor(s): Samadfam, Mohammad; Saligheh Rad, Hamid Reza
  7. Abstract:
  8. 1H-MRS thermometry as one of MRI thermometry methods, provides useful information about the distribution of the absolute temperature of tissue that can be used in diagnostic and therapeutic applications. It seems that the magnetic field inhomogeneity and the reduction of spectra resolution also affects the accuracy of MRS thermometry. To our knowledge, effects of magnetic field inhomogeneity on MRS thermometry has never been reported. In this study, we evaluated the effect of susceptibility inhomogeneity on MRS thermometry. In the first stage, MRS thermometry equation was derived in the presence of field inhomogeneity. Then simulation used for estimate the effect of filed inhomogeneity based on new equation. This simulation was done for three common in-vivo condition including fat, blood vessel and air-tissue interface. At the end, experimental studies were conducted to evaluate the temperature error in these situations. The simulation results showed that significant temperature error can be created due to increasing in FWHM of peaks in the presence of magnetic field inhomogeneity. In the experimental results, changes in central frequency of peaks are observed that cause additional temperature error. The main result of this study shows magnetic field inhomogeneity can affect MRS temperature map
  9. Keywords:
  10. Chemical Shift ; Magnetic Susceptibility ; Nuclear Magnetic Resonance Spectroscopy ; Thermometery ; Full Width at Half Maximum (FWHM)

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