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Feasibility of using bulk metallic glass for self-expandable stent applications

Praveen Kumar, G ; Sharif University of Technology

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  1. Type of Document: Article
  2. DOI: 10.1002/jbm.b.33718
  3. Abstract:
  4. Self-expandable stents are widely used to restore blood flow in a diseased artery segment by keeping the artery open after angioplasty. Despite the prevalent use of conventional crystalline metallic alloys, for example, nitinol, to construct self-expandable stents, new biomaterials such as bulk metallic glasses (BMGs) are being actively pursued to improve stent performance. Here, we conducted a series of analyses including finite element analysis and molecular dynamics simulations to investigate the feasibility of using a prototypical Zr-based BMG for self-expandable stent applications. We model stent crimping of several designs for different percutaneous applications. Our results indicate that BMG-based stents with diamond-shaped crowns suffer from severe localization of plastic deformation and abrupt failure during crimping. As a possible solution, we further illustrate that such abrupt failure could be avoided in BMG-based stents without diamond shape crowns. This work would open a new horizon for a quest toward exploiting superior mechanical and functional properties of metallic glasses to design future stents. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1874–1882, 2017. © 2016 Wiley Periodicals, Inc
  5. Keywords:
  6. Finite element analysis ; Biomaterials ; Finite element method ; Metals ; Molecular dynamics ; Stents ; Crimping ; Molecular dynamics simulations ; Nitinol ; Self-expandable ; Metallic glass ; Bulk metallic glass ; Glass ; Unclassified drug ; Zirconium ; Carotid artery stenting ; Cava valve implantation ; Mitral valve replacement ; Self expanding stent ; Transcatheter aortic valve implantation ; Transcatheter mitral valve replacement ; Vascular surgery
  7. Source: Journal of Biomedical Materials Research - Part B Applied Biomaterials ; Volume 105, Issue 7 , 2017 , Pages 1874-1882 ; 15524973 (ISSN)
  8. URL: https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.b.33718