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Poly(N-isopropylacrylamide)-coated β-cyclodextrin–capped magnetic mesoporous silica nanoparticles exhibiting thermal and pH dual response for triggered anticancer drug delivery

Pourjavadi, A ; Sharif University of Technology | 2017

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  1. Type of Document: Article
  2. DOI: 10.1080/00914037.2016.1217531
  3. Publisher: Taylor and Francis Inc , 2017
  4. Abstract:
  5. In this research a novel controlled anticancer drug delivery system with dual pH and thermal responses was designed based on magnetic mesoporous silica nanoparticles that were anchored by β-cyclodextrin and coated by poly(N-isopropylacrylamide) (PNIPAM). Results demonstrated that the behavior of doxorubicin (anticancer drug) release depended on pH and temperature conditions. At endosomal pH (pH 5.5) the amount of drug release enhanced because the cap was removed from the pores. Furthermore, PNIPAM shell collapsed above the lower critical solution temperature and the releasing of drug increased. Thus, this nanocarrier would have the potential to be applied in the tumor therapy. © 2017 Taylor & Francis
  6. Keywords:
  7. doxorubicin ; magnetic mesoporous silica nanoparticles ; poly(N-isopropylacrylamide) ; β-cyclodextrin ; Acrylic monomers ; Amides ; Cyclodextrins ; Magnetism ; Mesoporous materials ; Nanomagnetics ; Nanoparticles ; Silica ; Anti-cancer drug delivery ; Beta-cyclodextrin ; Doxorubicin ; Lower critical solution temperature ; Magnetic mesoporous silicas ; Poly (n isopropylacrylamide) ; Poly(N-isopropyl acrylamide) (pNIPAM) ; Temperature conditions ; Controlled drug delivery
  8. Source: International Journal of Polymeric Materials and Polymeric Biomaterials ; Volume 66, Issue 7 , 2017 , Pages 336-348 ; 00914037 (ISSN)
  9. URL: https://www.tandfonline.com/doi/full/10.1080/00914037.2016.1217531