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Synthesis, characterization and biological evaluation of a well dispersed suspension of gallium-68-labeled magnetic nanosheets of graphene oxide for in vivo coincidence imaging

Fazaeli, Y ; Sharif University of Technology | 2017

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  1. Type of Document: Article
  2. DOI: 10.1515/ract-2015-2556
  3. Publisher: Walter de Gruyter GmbH , 2017
  4. Abstract:
  5. Graphene oxide (GO) nanosheets were hybridized with Fe3O4 nanoparticles (NPs) to form magnetic GO (MGO) and were further labeled by [68Ga]GaCl3 as a potential drug delivery system. Paper chromatography, Fourier transform infra red (FTIR) spectroscopy, low-angle X-ray diffraction (XRD), CHN and atomic force microscopy (AFM) were utilized to characterize the trinary composite ([68Ga]@MGO). Biological evaluations of the prepared nanocomposite were performed in normal Sprague Dawley rats and it was found to be a possible host for theranostic radiopharmaceuticals. The results showed that the grafting of Fe3O4 NPs on nanocomposite reduced the unwanted liver and spleen uptakes and increased the ratio of kidney/liver uptake from 0.037 to 1.07, leading to the fast removal of radioactive agent and less imposed radiation to patients. The high level of hydrogen bonding caused by the presence of functional groups is responsible for this effect. Considering the accumulation of the tracer in vital organs of rat (especially brain), efficient iron oxide grafting, fast wash-out, the short half-life gallium-68 and less imposed radiation doses to patients, this nanocomposite could be a suitable candidate for positron emission tomography (PET) studies and imaging applications. © 2017 Walter de Gruyter GmbH, Berlin/Boston 2017
  6. Keywords:
  7. 68Ga ; Drug delivery ; Graphene ; Imaging ; Iron oxide
  8. Source: Radiochimica Acta ; Volume 105, Issue 1 , 2017 , Pages 65-73 ; 00338230 (ISSN)
  9. URL: https://www.degruyter.com/view/j/ract.ahead-of-print/ract-2015-2556/ract-2015-2556.xml