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Preparation and Forming of Nerve Growth Channels from Polymeric Nanocomposite by Solution Extrusion and Studing their Properties

Bayat, Arman | 2017

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 50627 (06)
  4. University: Sharif University of Technology
  5. Department: Chemical and Petroleum Engineering
  6. Advisor(s): Ramazani Saadatabadi, Ahmad
  7. Abstract:
  8. The nervous system is the most complex body system and controls other body systems. Damages of the peripheral nervous system will interfere with the functioning of the body. Tissue engineering is used as one of the most effective methods for repairing damaged tissues,by providing 3-dimensional (scaffold) bedding with proper properties, allows the proliferation of Myelin sheath and proliferation of axons. In this study, we used a continuous extrusion process, sodium alginate with different percentages of Polyaniline-Graphene nanoparticle (synthesized by solvent emulsion) was extruded and its properties were determined by FTIR, SEM, MTT, tensile properties, Conductivity, contact angles and biodegradability were investigated. The scaffolds were with the shape of hollow tubes that uses in separation processes. The results of the SEM test showed that using solvent extrusion method, will produce scaffolds with a hollow tube shape. These scaffolds were at the proper shape, In addition to the suitable porosity properties. The results of the mechanical properties test showed that the presence of Polyaniline-Graphene nanoparticle improved mechanical properties but reduces pore size. The MTT test showed that the nanoparticles did not produce toxicity in the scaffold and cells had adequate growth and proliferation
  9. Keywords:
  10. Nanocomposite ; Conductive Polymer ; Peripheral Nerve Injury ; Tissue Engineering ; Nerve Guidance Conduit ; Extrusion ; Nerve Tissue Engineering

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