Loading...

Empirical modeling of mechanical properties of modified collagen/chitosan membrane by response surface methodology

Ansarizadeh, M ; Sharif University of Technology | 2018

883 Viewed
  1. Type of Document: Article
  2. DOI: 10.1109/ICBME.2017.8430222
  3. Publisher: Institute of Electrical and Electronics Engineers Inc , 2018
  4. Abstract:
  5. In this study, collagen/chitosan membrane used for guided bone regeneration (GBR) was modified. Collagen and chitosan are routinely used in GBR membrane fabrication. In addition advanced platelet rich fibrin (A-PRF) is a promising substitution for fabricating membrane in dental surgery. Herein, acid soluble collagen from calf skin was extracted and characterized. The combination of A-PRF with collagen/chitosan membrane was investigated in this study. FTIR analysis revealed that chemical crosslinking using EDC/NHS was occurred. The morphology of collagen/chitosan membrane in a gradient manner of chitosan was assessed via SEM images. Response surface methodology (RSM) was used to quantitatively study the effect of parameters, including chitosan/collagen weight ratio (chit/col) and A-PRF concentration on the mechanical behavior of the fabricated membrane. Results showed that Young's modulus of the prepared membrane increased by increasing and decreasing of chit/col and A-PRF concentration, respectively. © 2017 IEEE
  6. Keywords:
  7. Advanced platelet rich fibrin ; Collagen/chitosan membrane ; GBR ; Response surface methodology ; Stiffness ; Biomedical engineering ; Biophysics ; Chemical analysis ; Chitosan ; Collagen ; Crosslinking ; Elastic moduli ; Platelets ; Surface properties ; Acid-soluble collagen ; Chemical cross-linking ; Effect of parameters ; Guided bone regeneration ; Mechanical behavior ; Membrane fabrication ; Membranes
  8. Source: 24th Iranian Conference on Biomedical Engineering and 2017 2nd International Iranian Conference on Biomedical Engineering, ICBME 2017, 30 November 2017 through 1 December 2017 ; 2018 ; 9781538636091 (ISBN)
  9. URL: https://ieeexplore.ieee.org/document/8430222