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Synthesis of Bone graft Substitute for Clinical Applications

Khodabakhshi Tabar Ahangar, Zahra | 2019

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 51969 (06)
  4. University: Sharif University of Technology
  5. Department: Chemical and Petroleum Engineering
  6. Advisor(s): Abdekhodaie, Mohammad Jafar
  7. Abstract:
  8. The natural tissue of the bones consists of organic and inorganic parts. The bone mineral part contains calcium phosphate and its organic part is mainly of collagen fibers. The combination of these fibers and calcium phosphate makes the bone flexible and resistant to stresses. Many conditions, including osteoporosis and crashes, lead to fractures and cavities in bone. Bone cements are the most used materials used in orthopedic surgeries and spinal cord.The purpose of this study was to synthesis acrylic bone cement with properties determined by ASTM F 451 and Iso5833 for orthopedic applications, including joint replacement. Polymethyl methacrylate polymer was synthesized as the main component of bone cement powder with 266341 Dalton average molecular weight and less than 300 micrometers in diameter by free radical polymerization of methyl methacrylate monomer. to optimize the conversion ratio and the properties of the final powder, experiments were carried out in different conditions, including for different values of the initiator, at different temperatures and times, and in the presence of nitrogen gas flow. The polymerization reaction of distilled methylmethacrylate occurred at 85 ° C for a laminar flow of nitrogen gas. The reaction completed after Two days reflux. Ultimately, spherical and regular polymeric beads were used to prepare bone cement powder. The properties of synthesized bone cement were determined by structural analysis of FTIR, HNMR, and GPC on the polymer, as well as temperature tests and mechanical properties on bone cement.Fatty acids in natural oils were used to solve one of the major problems with bone cement. Adding castor oil, linseed, and sesame oils while maintaining mechanical properties for orthopedic applications can lower the maximum temperature to 25 degrees Celsius. The synthesized and improved bone cement in this project is expected to be used for orthopedic applications
  9. Keywords:
  10. Acrylic Bone Cement ; Poly Methylmethacrylate ; Maximum Temperature ; Methylmethacrylate Monomer ; Natural Oils ; Acrylics Monomers

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