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Development of a quartz crystal microbalance biodetector based on cellulose nanofibrils (CNFs) for glycine

Hosseini, M. S ; Sharif University of Technology | 2020

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  1. Type of Document: Article
  2. DOI: 10.1007/s10854-020-04301-x
  3. Publisher: Springer , 2020
  4. Abstract:
  5. The performance of a quartz crystal microbalance (QCM) used as a sensor/detector relies on the performance and quality of the film coated onto the quartz crystal sensor. This study focuses on the sensor coating preparation for the detection of glycine. Cellulose nanofibrils (CNFs), natural polymers, were coated on a quartz crystal (QC) surface by a spin-coating method. The prepared CNF-coated QC was characterized by scanning electron microscopy (SEM), atomic force microscopy (AFM), cyclic voltammetry (CV), Fourier transform infrared spectrophotometry-attenuated total reflectance (FTIR-ATR), Raman spectroscopy, and water contact angle (WCA). The stable and fully covered QCs without further modification were then employed for aqueous glycine detection. Detection with a wide concentration range (3–1000 μg/mL) of glycine was studied. The resonance frequency shifts obtained from the samples during each step of the measurement are presented and discussed. The data show a linear range of detection (R2 = 0.9945) for 6–500 μg/mL of glycine and a limit of detection (LOD) of 8 μg/mL. This study indicates that the CNF-coated QCM has a potential application as a biodetector for glycine detection. © 2020, Springer Science+Business Media, LLC, part of Springer Nature
  6. Keywords:
  7. Amino acids ; Atomic force microscopy ; Cellulose ; Cellulose nanocrystals ; Coatings ; Contact angle ; Crystals ; Cyclic voltammetry ; Electron spin resonance spectroscopy ; Fourier transform infrared spectroscopy ; Nanofibers ; Quartz ; Scanning electron microscopy ; Attenuated total reflectance ; Cellulose nanofibrils (CNFs) ; Concentration ranges ; Fourier transform infrared spectrophotometry ; Quartz crystal sensors ; Resonance frequency shift ; Spin-coating method ; Water contact angle (WCA) ; Quartz crystal microbalances
  8. Source: Journal of Materials Science: Materials in Electronics ; Volume 31, Issue 20 , 2020 , Pages 17451-17460
  9. URL: https://link.springer.com/article/10.1007/s10854-020-04301-x