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Fabrication of Bioactive Bone Cement

Mansoori Kermani, Amir Reza | 2021

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 54436 (06)
  4. University: Sharif University of Technology
  5. Department: Chemical and Petroleum Engineering
  6. Advisor(s): Bahrevari, Mohammad Reza; Mashayekhan, Shohreh; Abd Khodaei, Mohammad Jafar
  7. Abstract:
  8. PMMA bone cement lacks biodegradability and the ability to bond with surrounding bone tissue. Therefore, the development of a new generation of bioactive bone cements that are biodegradable and possess adequate mechanical properties as well as desirable setting time is receiving remarkable interest.In this study, we have developed novel mineral-based bioactive bone cements. Our mineral bioactive bone cements were composed of Calcium Sulfate Hemihydrate, Bioactive Glass, and Tricalcium Silicate. Firstly, a binary system composed of Calcium Sulfate Hemihydrate and Bioactive Glass was optimized based on mechanical and setting behavior. Secondly, Tricalcium Silicate was added to the powder phase of the optimized binary system in order to fabricate different groups of our composite bone cement.The smaples were characterized in terms of physical and mechanical properties. Bioactivity of bone cements were investigated by FESEM and XRD results after the samples had been immersed in simulated body fluid for 21 days.All the demonstrated 90%< injectability, favorable handling properties, initial setting time of less than 14 minutes. The initial compressive strength for all the samples was higher than 12 MPa, which is higher than that of cancellous bone. Also, after 14 days immersion in SBF, compressive strength increased up to 48 MPa. More interestingly, the novel cements have shown Hydroxyapatite formation (bioactivity), controlled biodegradability, and in-vitro biocompatibility when being exposed to mesenchymal stem cells
  9. Keywords:
  10. Bioactive Glass ; Calcium Sulfate ; Biocementation ; Bone Tissue Replacement ; Tricalcium Silicate ; Injectable Bone Cement ; Bone Regeneration

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