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Theoretical study of diffusional release of a dispersed solute from a hollow cylindrical polymeric matrix

Jooybar, E ; Sharif University of Technology | 2021

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  1. Type of Document: Article
  2. DOI: 10.24200/sci.2021.53502.3271
  3. Publisher: Sharif University of Technology , 2021
  4. Abstract:
  5. The present study proposes an exact solution for the release kinetic of a solute from inside a hollow cylindrical polymeric matrix into an infinite medium when the initial concentration of the solute (A) is greater than the solubility limit (Cs). A combination of analytical and numerical methods was used to calculate the solute concentration profile and the release rate. The model was developed for two different conditions including: (1) The release medium was flowing through the hollow cylinder in which the boundary layer may be neglected, and (2) The release medium inside the hollow cylinder was stagnant where the boundary layer needed to be considered. The results indicated that the release profiles were close to the constant release rate after a typical burst release. Also, the release profile from a solid cylindrical matrix was compared to that of a hollow cylinder. The results indicated that the hollow cylindrical matrix was a promising carrier when the zero-order release was desirable. The present model demonstrated the potential of the hollow cylindrical matrix as a suitable geometry for sustained drug delivery systems. © 2021 Sharif University of Technology. All rights reserved
  6. Keywords:
  7. Boundary layers ; Controlled drug delivery ; Cylinders (shapes) ; Numerical methods ; Polymers ; Analytical and numerical methods ; Cylindrical matrices ; Drug delivery system ; Initial concentration ; Polymeric matrices ; Solubility limits ; Solute concentrations ; Zero-order release ; Targeted drug delivery ; Concentration (composition) ; Diffusion ; Polymer ; Solute transport
  8. Source: Scientia Iranica ; Volume 28, Issue 3 , 2021 , Pages 1428-1435 ; 10263098 (ISSN)
  9. URL: http://scientiairanica.sharif.edu/article_22199.html