Loading...
Search for: targeted-drug-delivery
0.006 seconds
Total 103 records

    Targeted nanomedicines for the treatment of bone disease and regeneration

    , Article Medicinal Research Reviews ; 2020 Ordikhani, F ; Zandi, N ; Mazaheri, M ; Luther, G. A ; Ghovvati, M ; Akbarzadeh, A ; Annabi, N ; Sharif University of Technology
    John Wiley and Sons Inc  2020
    Abstract
    Targeted delivery by either passive or active targeting of therapeutics to the bone is an attractive treatment for various bone related diseases such as osteoporosis, osteosarcoma, multiple myeloma, and metastatic bone tumors. Engineering novel drug delivery carriers can increase therapeutic efficacy and minimize the risk of side effects. Developmnet of nanocarrier delivery systems is an interesting field of ongoing studies with opportunities to provide more effective therapies. In addition, preclinical nanomedicine research can open new opportunities for preclinical bone-targeted drug delivery; nevertheless, further research is needed to progress these therapies towards clinical... 

    Drug delivery and adhesion of magnetic nanoparticles coated nanoliposomes and microbubbles to atherosclerotic plaques under magnetic and ultrasound fields

    , Article Engineering Applications of Computational Fluid Mechanics ; Volume 15, Issue 1 , 2021 , Pages 1703-1725 ; 19942060 (ISSN) Alishiri, M ; Ebrahimi, S ; Shamloo, A ; Boroumand, A ; Mofrad, M. R. K ; Sharif University of Technology
    Taylor and Francis Ltd  2021
    Abstract
    The use of external fields such as magnet and ultrasound to enhance the targeted drug delivery (TDD) by nano-microcarriers could be a potential method. In this research, the drug delivery of magnetic nanoparticles (NPs) coated nanoliposomes and microbubbles (MBs) to the atherosclerosis plaque was investigated under magnetic and ultrasound fields in terms of their adhesion to the plaque through ligand–receptor binding. The Halbach arrangement enhanced the surface density of nanoliposomes and MBs adhered to the plaque by ∼ (Formula presented.) and ∼ (Formula presented.), respectively. A focused transducer at the power of (Formula presented.) led to better drug delivery performance and caused ∼... 

    Drug delivery and adhesion of magnetic nanoparticles coated nanoliposomes and microbubbles to atherosclerotic plaques under magnetic and ultrasound fields

    , Article Engineering Applications of Computational Fluid Mechanics ; Volume 15, Issue 1 , 2021 , Pages 1703-1725 ; 19942060 (ISSN) Alishiri, M ; Ebrahimi, S ; Shamloo, A ; Boroumand, A ; Mofrad, M. R. K ; Sharif University of Technology
    Taylor and Francis Ltd  2021
    Abstract
    The use of external fields such as magnet and ultrasound to enhance the targeted drug delivery (TDD) by nano-microcarriers could be a potential method. In this research, the drug delivery of magnetic nanoparticles (NPs) coated nanoliposomes and microbubbles (MBs) to the atherosclerosis plaque was investigated under magnetic and ultrasound fields in terms of their adhesion to the plaque through ligand–receptor binding. The Halbach arrangement enhanced the surface density of nanoliposomes and MBs adhered to the plaque by ∼ (Formula presented.) and ∼ (Formula presented.), respectively. A focused transducer at the power of (Formula presented.) led to better drug delivery performance and caused ∼... 

    Study and simulation of nanoparticle translocation through cell membrane

    , Article Iranian Journal of Science and Technology - Transactions of Mechanical Engineering ; 2019 ; 22286187 (ISSN) Nejat Pishkenari, H ; Barzegar, M. R ; Taghibakhshi, A ; Sharif University of Technology
    Springer International Publishing  2019
    Abstract
    In this research, nanoparticle translocation through cell membrane has been studied and simulated. To this end, gold nanoparticles have been selected as the main carrier of the drug and have been functionalized with some selected ligands. The partial charges of the ligands have been calculated using quantum mechanics based on HF technique with 6-31Gd basis set. To achieve the realistic shape of a drug, the number and arrangement of ligands loaded on the gold nanoparticle have been optimized. After determining the properties such as diffusion coefficient and validating the results with experimental data, a MARTINI coarse-grained mapping of the drugs is created. The coarse-grained model of the... 

    Study and Simulation of Nanoparticle Translocation Through Cell Membrane

    , Article Iranian Journal of Science and Technology - Transactions of Mechanical Engineering ; Volume 45, Issue 4 , 2021 , Pages 939-960 ; 22286187 (ISSN) Nejat Pishkenari, H ; Barzegar, M. R ; Taghibakhshi, A ; Sharif University of Technology
    Springer Science and Business Media Deutschland GmbH  2021
    Abstract
    In this research, nanoparticle translocation through cell membrane has been studied and simulated. To this end, gold nanoparticles have been selected as the main carrier of the drug and have been functionalized with some selected ligands. The partial charges of the ligands have been calculated using quantum mechanics based on HF technique with 6-31Gd basis set. To achieve the realistic shape of a drug, the number and arrangement of ligands loaded on the gold nanoparticle have been optimized. After determining the properties such as diffusion coefficient and validating the results with experimental data, a MARTINI coarse-grained mapping of the drugs is created. The coarse-grained model of the... 

    Engineered hyaluronic acid-decorated niosomal nanoparticles for controlled and targeted delivery of epirubicin to treat breast cancer

    , Article Materials Today Bio ; Volume 16 , 2022 ; 25900064 (ISSN) Mansoori Kermani, A ; Khalighi, S ; Akbarzadeh, I ; Niavol, F. R ; Motasadizadeh, H ; Mahdieh, A ; Jahed, V ; Abdinezhad, M ; Rahbariasr, N ; Hosseini, M ; Ahmadkhani, N ; Panahi, B ; Fatahi, Y ; Mozafari, M ; Kumar, A. P ; Mostafavi, E ; Sharif University of Technology
    Elsevier B.V  2022
    Abstract
    Targeted drug delivery systems using nanocarriers offer a versatile platform for breast cancer treatment; however, a robust, CD44-targeted niosomal formulation has not been developed and deeply studied (both in vitro and in vivo) yet. Here, an optimized system of epirubicin (Epi)-loaded niosomal nanoparticles (Nio) coated with hyaluronic acid (HA) has been engineered for targeting breast cancer cells. The nanoformulation was first optimized (based on size, polydispersity index, and entrapment efficiency); then, we characterized the morphology, stability, and release behavior of the nanoparticles. Epirubicin release from the HA-coated system (Epi-Nio-HA) showed a 21% (acidic buffer) and 20%... 

    Submicron particle deposition in pulmonary alveoli during cyclic breathing

    , Article Scientia Iranica ; Volume 24, Issue 4 , 2017 , Pages 1975-1984 ; 10263098 (ISSN) Monjezi, M ; Saidi, M. S ; Ahmadi, G ; Sharif University of Technology
    Sharif University of Technology  2017
    Abstract
    The prediction of deposition efficiency of submicron particles in the pulmonary alveoli has received special attention due to its importance for drug delivery systems and for assessing air pollutants health risks. In this work, the pulmonary alveoli of a healthy human are idealized by a three-dimensional honeycomb-like configuration and a fluid-structure interaction analysis is performed. In contrast to previous works in which the inlet flow rate is predefined, in this model, a negative pressure is imposed on the outside surface of the flalveolus which causes air to flow in and out of the alveolus. The resulting flow patterns confirmed that there was no circulation in the terminal alveolus.... 

    Loading drug on nanostructured Ti6Al4V-HA for implant applications

    , Article International Journal of Engineering, Transactions B: Applications ; Volume 31, Issue 8 , 2018 , Pages 1159-1165 ; 1728144X (ISSN) Abbaspour, S ; Sadrnezhaad, S. K ; Sharif University of Technology
    Materials and Energy Research Center  2018
    Abstract
    Arrayed Ti6Al4V nanotubes (TNT) coated with hydroxyapatite (HA) were synthesized via electrochemical anodization method. Paracetamol was loaded onto TNT-HA electrode. Effects of anodization, nanotube formation and hydroxyapatite deposition on sorption and release of the drug were investigated. Saturation time of paracetamol on the anodized samples was 30% shorter than the hydroxyapatite-coated samples. Release behavior of the loaded drug was studied by (a) plunging the probe into phosphate buffered saline (PBS), (b) sampling the drug-loaded PBS at different times and (c) analyzing the solution via ultraviolet-visible (UV-vis) spectroscopy. Results showed that HA electrodes hold higher... 

    Theoretical study of diffusional release of a dispersed solute from cylindrical polymeric matrix: A novel configuration for providing zero-order release profile

    , Article Applied Mathematical Modelling ; Volume 73 , 2019 , Pages 136-145 ; 0307904X (ISSN) Khorrami Jahromi, A ; Shieh, H ; Saadatmand, M ; Sharif University of Technology
    Elsevier Inc  2019
    Abstract
    In the context of controlled release drug delivery approaches, the systems providing zero-order release kinetics have special advantages. Through employing these systems, drug concentration could be maintained within the therapeutic window over release time; thus maximum effectiveness alongside minimized side effects of the drug are achieved. However, obtaining zero-order drug release is extremely challenging. One of the main obstacles is the fact that implemented devices should be designed to overcome the decreasing mass transfer driving force, especially, in polymeric systems in which diffusion mechanism is dominant. In this study, we developed a new configuration of a polymeric matrix... 

    Micro and nanoscale technologies in oral drug delivery

    , Article Advanced Drug Delivery Reviews ; Volume 157 , 2020 , Pages 37-62 Ahadian, S ; Finbloom, J. A ; Mofidfar, M ; Diltemiz, S. E ; Nasrollahi, F ; Davoodi, E ; Hosseini, V ; Mylonaki, I ; Sangabathuni, S ; Montazerian, H ; Fetah, K ; Nasiri, R ; Dokmeci, M. R ; Stevens, M. M ; Desai, T. A ; Khademhosseini, A ; Sharif University of Technology
    Elsevier B.V  2020
    Abstract
    Oral administration is a pillar of the pharmaceutical industry and yet it remains challenging to administer hydrophilic therapeutics by the oral route. Smart and controlled oral drug delivery could bypass the physiological barriers that limit the oral delivery of these therapeutics. Micro- and nanoscale technologies, with an unprecedented ability to create, control, and measure micro- or nanoenvironments, have found tremendous applications in biology and medicine. In particular, significant advances have been made in using these technologies for oral drug delivery. In this review, we briefly describe biological barriers to oral drug delivery and micro and nanoscale fabrication technologies.... 

    The effect of chitosan and PEG polymers on stabilization of GF-17 structure: A molecular dynamics study

    , Article Carbohydrate Polymers ; Volume 237 , 2020 Asadzadeh, H ; Moosavi, A ; Arghavani Hadi, J ; Sharif University of Technology
    Elsevier Ltd  2020
    Abstract
    We examine the interactions of chitosan and polyethylene glycol (PEG) with antimicrobial peptide GF-17 to identify a suitable carrier to improve the peptide drug delivery systems. To this end, the molecular dynamics simulations are used to determine the interactions of a typical antimicrobial peptide GF-17 with the chitosan and PEG polymers. The findings indicate the great potential of the peptide to maintain its secondary structure in the adjacent to chitosan polymers. During the interaction with chitosan polymers, the structure of the peptide has smaller fluctuations compared to the PEG polymers. Also, in the presence of both the polymers, the PEG polymers are situated closer to the... 

    Dual-diffusivity stochastic model for macromolecule release from a hydrogel

    , Article ACS Applied Bio Materials ; Volume 3, Issue 7 , 2020 , Pages 4208-4219 Jahanmir, G ; Lau, C. M. L ; Abdekhodaie, M. J ; Chau, Y ; Sharif University of Technology
    American Chemical Society  2020
    Abstract
    A three-dimensional model has been developed to describe the multiphase release of macromolecular drugs encapsulated in a hydrogel. The heterogeneity of network mesh size was considered by assigning varying diffusion coefficients to the network lattices randomly. Using a stochastic approach, the random nature of diffusion of drug molecules was captured within the network. The simplest form of distribution containing two diffusion coefficients was tested. To generate the drug release profiles for experimental validation under the limitation of computational cost, a simple scaling relationship was employed. Unlike the single-diffusivity model, the dual-diffusivity model showed good agreement... 

    Facile design of autogenous stimuli-responsive chitosan/hyaluronic acid nanoparticles for efficient small molecules to protein delivery

    , Article Journal of Materials Chemistry B ; Volume 8, Issue 32 , 2020 , Pages 7275-7287 Sabourian, P ; Ji, J ; Lotocki, V ; Moquin, A ; Hanna, R ; Frounchi, M ; Maysinger, D ; Kakkar, A ; Sharif University of Technology
    Royal Society of Chemistry  2020
    Abstract
    Easily assembled and biocompatible chitosan/hyaluronic acid nanoparticles with multiple stimuli-responsive ability are ideally suited for efficient delivery of therapeutic agents under specific endogenous triggers. We report a simple and versatile strategy to formulate oxidative stress and pH-responsive chitosan/hyaluronic acid nanocarriers with high encapsulation efficiencies of small drug molecules and nerve growth factor protein. This is achieved through invoking the dual role of a thioketal-based weak organic acid to disperse and functionalize low molecular weight chitosan in one-pot. Thioketal embedded chitosan/hyaluronic acid nanostructures respond to oxidative stress and show... 

    Streptomycin sulfate–loaded niosomes enables increased antimicrobial and anti-biofilm activities

    , Article Frontiers in Bioengineering and Biotechnology ; Volume 9 , 2021 ; 22964185 (ISSN) Mansouri, M ; Khayam, N ; Jamshidifar, E ; Pourseif, T ; Kianian, S ; Mirzaie, A ; Akbarzadeh, I ; Ren, Q ; Sharif University of Technology
    Frontiers Media S.A  2021
    Abstract
    One of the antibiotics used to treat infections is streptomycin sulfate that inhibits both Gram-negative and -positive bacteria. Nanoparticles are suitable carriers for the direct delivery and release of drug agents to infected locations. Niosomes are one of the new drug delivery systems that have received much attention today due to their excellent biofilm penetration property and controlled release. In this study, niosomes containing streptomycin sulfate were prepared by using the thin layer hydration method and optimized based on the size, polydispersity index (PDI), and encapsulation efficiency (EE%) characteristics. It was found that the Span 60-to-Tween 60 ratio of 1.5 and the... 

    Metal-organic frameworks-based nanomaterials for drug delivery

    , Article Materials ; Volume 14, Issue 13 , 2021 ; 19961944 (ISSN) Saeb, M. R ; Rabiee, N ; Mozafari, M ; Mostafavi, E ; Sharif University of Technology
    MDPI AG  2021
    Abstract
    The composition and topology of metal-organic frameworks (MOFs) are exceptionally tailorable; moreover, they are extremely porous and represent an excellent Brunauer–Emmett–Teller (BET) surface area (≈3000–6000 m2·g−1). Nanoscale MOFs (NMOFs), as cargo nanocarriers, have increasingly attracted the attention of scientists and biotechnologists during the past decade, in parallel with the evolution in the use of porous nanomaterials in biomedicine. Compared to other nanoparticle-based delivery systems, such as porous nanosilica, nanomicelles, and dendrimer-encapsulated nanoparticles, NMOFs are more flexible, have a higher biodegradability potential, and can be more easily functionalized to meet... 

    Encapsulation of drug-loaded graphene oxide-based nanocarrier into electrospun pullulan nanofibers for potential local chemotherapy of breast cancer

    , Article Macromolecular Chemistry and Physics ; Volume 222, Issue 15 , 2021 ; 10221352 (ISSN) Asgari, S ; Pourjavadi, A ; Setayeshmehr, M ; Boisen, A ; Ajalloueian, F ; Sharif University of Technology
    John Wiley and Sons Inc  2021
    Abstract
    With the high rate of mortality associated with breast cancer among women, breast cancer treatment has attracted great deal of attention globally. To reduce the exposure of body organs to high cytotoxicity of the common chemotherapeutic drugs, local co-delivery of selected chemotherapeutics has emerged as a solution. In this work, an electrospun composite including a co-drug-loaded graphene oxide-based nanocarrier is fabricated for local anticancer applications. To increase dispersion and cellular uptake of graphene oxide (GO), first, the hydroxyl groups at the edges of GO are grafted by poly (epichlorohydrin) (PCH) to form GO-PCH. Then, the hydroxyl end groups of PCH are grafted (g) with... 

    Theoretical study of diffusional release of a dispersed solute from a hollow cylindrical polymeric matrix

    , Article Scientia Iranica ; Volume 28, Issue 3 , 2021 , Pages 1428-1435 ; 10263098 (ISSN) Jooybar, E ; Tajsoleiman, T ; Abdekhodaie, M. J ; Sharif University of Technology
    Sharif University of Technology  2021
    Abstract
    The present study proposes an exact solution for the release kinetic of a solute from inside a hollow cylindrical polymeric matrix into an infinite medium when the initial concentration of the solute (A) is greater than the solubility limit (Cs). A combination of analytical and numerical methods was used to calculate the solute concentration profile and the release rate. The model was developed for two different conditions including: (1) The release medium was flowing through the hollow cylinder in which the boundary layer may be neglected, and (2) The release medium inside the hollow cylinder was stagnant where the boundary layer needed to be considered. The results indicated that the... 

    Microfluidic-assisted fiber production: Potentials, limitations, and prospects

    , Article Biomicrofluidics ; Volume 16, Issue 6 , 2022 ; 19321058 (ISSN) Abrishamkar, A ; Nilghaz, A ; Saadatmand, M ; Naeimirad, M ; Demello, A. J ; Sharif University of Technology
    American Institute of Physics Inc  2022
    Abstract
    Besides the conventional fiber production methods, microfluidics has emerged as a promising approach for the engineered spinning of fibrous materials and offers excellent potential for fiber manufacturing in a controlled and straightforward manner. This method facilitates low-speed prototype synthesis of fibers for diverse applications while providing superior control over reaction conditions, efficient use of precursor solutions, reagent mixing, and process parameters. This article reviews recent advances in microfluidic technology for the fabrication of fibrous materials with different morphologies and a variety of properties aimed at various applications. First, the basic principles, as... 

    PH-Responsive chitosan-adorned niosome nanocarriers for co-delivery of drugs for breast cancer therapy

    , Article ACS Applied Nano Materials ; Volume 5, Issue 7 , 2022 , Pages 8811-8825 ; 25740970 (ISSN) Karimifard, S ; Rezaei, N ; Jamshidifar, E ; Moradi Falah Langeroodi, S ; Abdihaji, M ; Mansouri, A ; Hosseini, M ; Ahmadkhani, N ; Rahmati, Z ; Heydari, M ; Vosough, M ; Akbarzadeh, I ; Mostafavi, E ; Sharif University of Technology
    American Chemical Society  2022
    Abstract
    Breast cancer incidence has increased in recent decades. In the present study, an optimum formulation of chitosan (CS)-adorned niosome-based nanocarriers for co-delivery of doxorubicin (DOX) and vincristine (VIN) was developed for the treatment of breast cancer to reduce drug doses and overcome multidrug resistance. The three-level Box-Behnken method was utilized to optimize the particles in terms of size, polydispersity index (PDI), entrapment efficacy (EE (%)), and percent of drug release (%). The release rate of two drugs from CS-adorned nanoparticles (DOX+VIN/Nio/CS) in acidic and physiological pH is less than uncoated niosome (DOX+VIN/Nio). In addition, acidic pH increases the release... 

    Evaluation of anti-cancer and anti-metastatic effects of folate-PEGylated niosomes for co-delivery of letrozole and ascorbic acid on breast cancer cells

    , Article Molecular Systems Design and Engineering ; Volume 7, Issue 9 , 2022 , Pages 1102-1118 ; 20589689 (ISSN) Bourbour, M ; Khayam, N ; Noorbazargan, H ; Tavakkoli Yaraki, M ; Asghari Lalami, Z ; Akbarzadeh, I ; Eshrati Yeganeh, F ; Dolatabadi, A ; Mirzaei Rad, F ; Tan, Y. N ; Sharif University of Technology
    Royal Society of Chemistry  2022
    Abstract
    Fighting with cancer requires the delivery of different therapeutics to the target cancerous cells by taking advantage of the synergistic effects of complementary medicine. Herein, we present a folate-PEGylated niosome as an efficient nanocarrier for targeted co-delivery of hydrophobic letrozole (L) and hydrophilic ascorbic acid (A) to breast cancer cells. The formulation of the niosomal nanocarrier was optimized by varying the ratio of cholesterol and surfactants to maximize the drug loading and minimize the size of nanocarriers. The optimum drug carriers were further functionalized with folate-PEG molecules to enhance the efficiency of drug delivery to the breast cancer cells and prevent...