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Aluminum-based metal-organic frameworks for adsorptive removal of anti-cancer (methotrexate) drug from aqueous solutions

Ahmadijokani, F ; Sharif University of Technology | 2021

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  1. Type of Document: Article
  2. DOI: 10.1016/j.jenvman.2020.111448
  3. Publisher: Academic Press , 2021
  4. Abstract:
  5. A series of metal-organic frameworks (MOFs) based on aluminum-benzene dicarboxylates (MIL-53, NH2-MIL-53, and NH2-MIL-101) at different ratios have been synthesized, and their adsorption performances for methotrexate (MTX), an anti-cancer drug, have been investigated in terms of adsorption kinetics, isotherms, solution pH, thermodynamics, mechanism, and recyclability. Maximum adsorption values of 374.97, 387.82, and 457.69 mg/g were observed for MIL-53, NH2-MIL-53, and NH2-MIL-101, respectively. Our study shows that adsorption capacity of MTX depends not only on surface area and pore volume but also on the zeta potential and the presence of suitable functional groups. Higher adsorption of NH2-MIL-101 observed for MTX than the other synthesized MOFs may be attributed to its large surface area, large total pore volume, high positive zeta potential, and polar amino functional groups located on its surface, which are responsible for its increased interactions with MTX molecules. Adsorption isotherms and kinetics of MTX onto NH2-MIL-101 followed the Langmuir and pseudo-second-order kinetic equations. Thermodynamic data suggest that adsorption of MTX onto NH2-MIL-101 is spontaneous and exothermic, while the adsorption mechanism is governed by electrostatic interactions, π-π stacking interactions, and H-bonding. Regeneration and recyclability of NH2-MIL-101 were also investigated by washing with ethanol to observe its decreased adsorption performance towards MTX. It was slightly decreased after seven adsorption-desorption cycles, indicating excellent regeneration and good structural stability under the chosen experimental conditions. © 2020 Elsevier Ltd
  6. Keywords:
  7. Aluminum benzene dicarboxylate derivative ; Aluminum derivative ; Metal organic framework ; Methotrexate ; Unclassified drug ; Aqueous solution ; Controlled study ; Desorption ; Human ; Hydrogen bond ; Isotherm ; Pore volume ; Static electricity ; Surface area ; Waste component removal ; Water pollution ; Zeta potential ; Neoplasm ; Adsorption ; Aluminum ; Humans ; Metal-Organic Frameworks ; Methotrexate ; Neoplasms
  8. Source: Journal of Environmental Management ; Volume 277 , 2021 ; 03014797 (ISSN)
  9. URL: https://www.sciencedirect.com/science/article/pii/S0301479720313736