Loading...

Inserting the effects of ion channels in mean field models: Application to generation of anesthetic slow waves

Molaee Ardekani, B ; Sharif University of Technology | 2005

215 Viewed
  1. Type of Document: Article
  2. Publisher: 2005
  3. Abstract:
  4. In this paper, effects of general anesthesia on the electroencephalogram (EEC) has been modeled with an enhanced physiological mean field theory of electrocortical activity. Enhancement is done by inserting two intrinsic ion channels (IKNa and IAR) in Liley's mean field model. In addition to excitatory and inhibitory synapses, intrinsic ion channels can generate or manipulate the brain rhythms. IKNa and IAR can produce slow brain rhythms (delta band frequency) in deep levels of anesthesia. We represent the activities of each mentioned ion channels by cascading a nonlinear function and a first order low pass filter. Linearized and numerical solutions of the modified model show that the power spectrum densities of simulated EEC signals are more closed to reality. © 2005 IEEE
  5. Keywords:
  6. Anesthesia ; Delta waves ; Ion channels ; Anesthesiology ; Brain ; Low pass filters ; Mathematical models ; Mean field theory ; Physiology ; Electroencephalography
  7. Source: EUROCON 2005 - The International Conference on Computer as a Tool, Belgrade, 21 November 2005 through 24 November 2005 ; Volume I , 2005 , Pages 378-381 ; 142440049X (ISBN); 9781424400492 (ISBN)
  8. URL: https://www.researchgate.net/publication/4241255_Inserting_the_Effects_of_Ion_Channels_in_Mean_Field_Models_Application_to_generation_of_anesthetic_slow_waves