Loading...

Fabrication of Janus Micromotors Based on Black Titanium Dioxide for Medical Application

Amiri, Zahra | 2022

167 Viewed
  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 55199 (07)
  4. University: Sharif University of Technolog
  5. Department: Materials Science and Engineering
  6. Advisor(s): Madaah Hosseini, Hamid Reza; Tavakoli, Rohollah
  7. Abstract:
  8. Enzyme-powered motors self-propel through the catalysis of biofuels, which makes them excellent candidates for biomedical applications. However, fundamental issues such as their movement in biological fluids and understanding the mechanism of propulsion are important aspects that must be considered before application in biomedicine. Building active systems based on biocompatible materials that use non-toxic fuels to power their vehicles have always been challenging. In this study, self-propelled micromotors consist of titanium dioxide black spheres asymmetrically coated with a thin layer of gold. Cysteine was used to bind urease enzyme due to thiol binding. By biocatalytically converting urea through urease, at biologically related concentrations, the driving force of micromotors is provided and causes them to move. Examination of the speed of micromotors shows that with increasing urea concentration to a degree of saturation, the speed increases and then decreases. The motion of micromotors in sodium chloride and phosphate-buffer saline was also studied to investigate the effect of ionic environments simulated with the body. Due to the ability to use these micromotors in the bladder, their movement in the urine environment was also investigated that particles with an average speed of 32.29 μm/s are able to move. These results indicate a significant potential for the development of targeted cancer treatment and the possibility of diagnosis using biocompatible micromotors. Therefore, the cytotoxicity of micromotors was studied and in all cases the cell debris rate was more than 88%. Due to the ability to excite titanium dioxide particles in the near-infrared range and lack of cytotoxicity, these micromotors can be used as a photothermal agent in the treatment of bladder cancer.

  9. Keywords:
  10. Janus Nanoparticles ; Janus Micromotor ; Urease ; Self-Propelled Particles ; Black Titanium Dioxide ; Enzymatic Micromotors

 Digital Object List

 Bookmark

No TOC