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A simple one-pot three-component reaction for preparation of secondary amines and amino esters mediated by lithium perchlorate

Saidi, M. R ; Sharif University of Technology | 2001

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  1. Type of Document: Article
  2. DOI: 10.1016/S0040-4020(01)00636-6
  3. Publisher: 2001
  4. Abstract:
  5. The one-pot synthesis of several secondary amines and secondary amino esters are reported. Treatment of aldehydes (aliphatic or aromatic) with (trimethylsilyl)alkylamines, in the presence of 5 M lithium perchlorate in diethyl ether gives intermediate imines. Reaction of these intermediate imines with different nucleophiles and functionalized organozinc reagents, BrZnCH2COOR, produce a variety of secondary amines and N-alkyl- or N-arylamino esters in good yields. © 2001 Elsevier Science Ltd. All rights reserved
  6. Keywords:
  7. Aminoesters ; Lithium perchlorate ; Secondary amines
  8. Source: Tetrahedron ; Volume 57, Issue 31 , 2001 , Pages 6829-6832 ; 00404020 (ISSN)
  9. URL: https://www.sciencedirect.com/science/article/abs/pii/S0040402001006366