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Continuous submicron particle separation Via Vortex-Enhanced ionic concentration polarization: a numerical investigation

Dezhkam, R ; Sharif University of Technology | 2022

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  1. Type of Document: Article
  2. DOI: 10.3390/mi13122203
  3. Publisher: MDPI , 2022
  4. Abstract:
  5. Separation and isolation of suspended submicron particles is fundamental to a wide range of applications, including desalination, chemical processing, and medical diagnostics. Ion concentration polarization (ICP), an electrokinetic phenomenon in micro-nano interfaces, has gained attention due to its unique ability to manipulate molecules or particles in suspension and solution. Less well understood, though, is the ability of this phenomenon to generate circulatory fluid flow, and how this enables and enhances continuous particle capture. Here, we perform a comprehensive study of a low-voltage ICP, demonstrating a new electrokinetic method for extracting submicron particles via flow-enhanced particle redirection. To do so, a 2D-FEM model solves the Poisson–Nernst–Planck equation coupled with the Navier–Stokes and continuity equations. Four distinct operational modes (Allowed, Blocked, Captured, and Dodged) were recognized as a function of the particle’s charges and sizes, resulting in the capture or release from ICP-induced vortices, with the critical particle dimensions determined by appropriately tuning inlet flow rates (200–800 [µm/s]) and applied voltages (0–2.5 [V]). It is found that vortices are generated above a non-dimensional ICP-induced velocity of u* = 1, which represents an equilibrium between ICP velocity and lateral flow velocity. It was also found that in the case of multi-target separation, the surface charge of the particle, rather than a particle’s size, is the primary determinant of particle trajectory. These findings contribute to a better understanding of ICP-based particle separation and isolation, as well as laying the foundations for the rational design and optimization of ICP-based sorting systems. © 2022 by the authors
  6. Keywords:
  7. DC dielectrophoresis (DEP) ; Ion concentration polarization (ICP) ; Desalination ; Diagnosis ; Electrodynamics ; Flow velocity ; Navier Stokes equations ; Polarization ; Screening ; Suspensions (fluids) ; Viruses ; Vortex flow ; DC dielectrophoresis ; Disease extraction ; Ion concentration polarizations ; Ionic concentrations ; Particle manipulation ; Submicron particle ; Submicron particle separation ; Virus detection ; Water purification ; Electrophoresis
  8. Source: Micromachines ; Volume 13, Issue 12 , 2022 ; 2072666X (ISSN)
  9. URL: https://www.mdpi.com/2072-666X/13/12/2203