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- Type of Document: M.Sc. Thesis
- Language: Farsi
- Document No: 56508 (06)
- University: Sharif University of Technology
- Department: Chemical and Petroleum Engineering
- Advisor(s): Frounchi, Masoud
- Abstract:
- In recent years, the tendency to use biodegradable and biocompatible polymer nanoparticles for drug delivery applications has been increasing, the reason for this being the possibility of precise control of the drug release rate, ease of use, and no need for external Surgery after the release of the drug, increases the therapeutic efficiency of the drug and reduces the side effects with its precise transfer. In this research work, drug carrier nanocomposites were prepared from polylactic acid (PLA), polyethylene glycol (PEG) and hydroxyapatite (HAp) and for the controlled release of ciprofloxacin (CIP). It was used to treat bone infections. The drug loading efficiency for nano-carriers was measured and it was observed that adding 20 and 30% PEG to the composition increased the drug loading efficiency from 42% to 60 and 76%. Also, the release profile of the drug in vitro in phosphate buffered saline (PBS) solution was measured by ultraviolet spectroscopy (UV-VIS) and it confirmed the reduction of the initial explosive release of the drug up to 50% and the increase of the final release of the drug due to the addition of PEG and HAp. Therefore, a long-term release mechanism with a constant rate was observed for the ciprofloxacin drug, and the nanoparticles also showed long-term stability. The results showed that nano-composites with ciprofloxacin drug are capable of delayed release of ciprofloxacin for up to 30 days. Therefore, PLA-PEG-HAp polymer nanoparticles are an efficient carrier for controlled release drug delivery systems. In order to characterize the prepared drug delivery system, the necessary analyzes were performed on the samples. The interaction between the drug and hydroxyapatite nanoparticles was confirmed using infrared spectroscopic analysis (FTIR) and scanning electron microscope (SEM) imaging was used to observe the size and structure of the formed porous particles. In X-ray Diffraction (XRD) analysis, the crystalline peaks of the materials were examined and it was observed that the interaction between them causes the removal of the crystalline peaks and the creation of an amorphous structure in the final nanocomposite. Also, in the antibacterial test, the effect of the presence of different amounts of hydroxyapatite and polyethylene glycol on the release of the loaded drug was investigated by comparing the diameter of the zone of inhibition bacteria in the prepared samples
- Keywords:
- Drug Release ; Polylactic Acid ; Hydroxyapatite ; Drug Carrier ; Ciprofloxacin Antibiotic ; Drug Loading ; Polyethylen Glycol (PEG) ; Polymeric Drug Nanoparticles
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