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Evaluation of Nanobiocomposite Based on Thermoplastic Starch for Bone Tissue Engineering Applications

Taherimehr, Marzieh | 2012

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 42535 (07)
  4. University: Sharif University of Technology
  5. Department: Materials Science and Engineering
  6. Advisor(s): Bagheri, Reza; Maddah Hosseini, Hamid Reza
  7. Abstract:
  8. Development of new engineered materials for bone tissue engineering applications is rapidly growing. The most important characteristics of materials, which can be used for bone tissue engineering applications, are appropriate mechanical properties, degradation rate, swelling behavior, and bioactivity. The goal of the current investigation is to study the feasibility of incorporating a modified nano-biocomposite based on biodegradable thermoplastic starch for bone tissue engineering. Nano particles of ?-tricalcium phosphate and hydroxyapatite were incorporated for reinforcing the matrix as well as improving the bioactivity. A second biodegradable polymer, i.e. polycaprolactone, was used to optimize the properties. Mechanical properties of the nanocomposites, as well as their degradation behavior in simulated body fluid (SBF), were studied. Additionally, other factors such as weight loss, swelling degree, and biomineralization in SBF were investigated. Results show that swelling degree and weight loss of three and four components nanocomposites decreased 90% and 80% respectively, which can cause more dimentional stability for the nanocomposite. In addition, Young's modulus of thermoplastic starch, two, three and four components nanocomposites are 66.5, 390.5, 335.9, and 280.1, respectively. Scanning electron microscopy was utilized to characterize both dispersion of ?-tricalcium particles in the matrix and biomineralization of the nanocomposite after incubation in SBF. The results of this study illustrate the positive impact of incorporating polycaprolactone on both mechanical properties and degradation behavior of the nanocomposite.Development of new engineered materials for bone tissue engineering applications is rapidly growing. The most important characteristics of materials, which can be used for bone tissue engineering applications, are appropriate mechanical properties, degradation rate, swelling behavior, and bioactivity. The goal of the current investigation is to study the feasibility of incorporating a modified nano-biocomposite based on biodegradable thermoplastic starch for bone tissue engineering. Nano particles of ?-tricalcium phosphate and hydroxyapatite were incorporated for reinforcing the matrix as well as improving the bioactivity. A second biodegradable polymer, i.e. polycaprolactone, was used to optimize the properties. Mechanical properties of the nanocomposites, as well as their degradation behavior in simulated body fluid (SBF), were studied. Additionally, other factors such as weight loss, swelling degree, and biomineralization in SBF were investigated. Results show that swelling degree and weight loss of three and four components nanocomposites decreased 90% and 80% respectively, which can cause more dimentional stability for the nanocomposite. In addition, Young's modulus of thermoplastic starch, two, three and four components nanocomposites are 66.5, 390.5, 335.9, and 280.1, respectively. Scanning electron microscopy was utilized to characterize both dispersion of ?-tricalcium particles in the matrix and biomineralization of the nanocomposite after incubation in SBF. The results of this study illustrate the positive impact of incorporating polycaprolactone on both mechanical properties and degradation behavior of the nanocomposite
  9. Keywords:
  10. Thermoplastic Starch ; Bone Tissue Engineering ; Nanobiocomposite ; B-Tricalcium Phosphate ; Polycaprolactone Composite

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