Design and Construction of PCL Nanofiber Scaffold for Bladder Tissue Engineering, M.Sc. Thesis Sharif University of Technology ; Yaghmaei, Soheyla (Supervisor) ; Mashayekhan, Shohreh (Co-Advisor)
Abstract
In this project, a novel system of bioactive electrospun scaffold for bladder tissue engineering , has been investigated to control in vitro cell differentiation, and utilize in in vivo vascularization and tissue formation. This method doesn’t have custom bioactive scaffolds problems such as, protein instability, technical complexity and, difficulties in accurate kinetics prediction. First of all, protein loaded chitosan nanoparticles based on ionic gelation interaction between chitosan and Sodium tripolyphosphate were prepared. Maximum protein loading efficiency (80% for BSA & 99% for TGF-beta1) in chitosan nanoparticles was obtained at mean diameter of 51nm. Moreover polycaprolactone...
Cataloging briefDesign and Construction of PCL Nanofiber Scaffold for Bladder Tissue Engineering, M.Sc. Thesis Sharif University of Technology ; Yaghmaei, Soheyla (Supervisor) ; Mashayekhan, Shohreh (Co-Advisor)
Abstract
In this project, a novel system of bioactive electrospun scaffold for bladder tissue engineering , has been investigated to control in vitro cell differentiation, and utilize in in vivo vascularization and tissue formation. This method doesn’t have custom bioactive scaffolds problems such as, protein instability, technical complexity and, difficulties in accurate kinetics prediction. First of all, protein loaded chitosan nanoparticles based on ionic gelation interaction between chitosan and Sodium tripolyphosphate were prepared. Maximum protein loading efficiency (80% for BSA & 99% for TGF-beta1) in chitosan nanoparticles was obtained at mean diameter of 51nm. Moreover polycaprolactone...
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