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Continuous Synthesis of Medicine Utilizing Catalyst Through a Microreactor System

Erfani Gahrooei, Amir Reza | 2022

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 55194 (06)
  4. University: Sharif University of Technolog
  5. Department: Chemical and Petroleum Engineering
  6. Advisor(s): Kazemeini, Mohammad; Khorasheh, Farhad; Hosseinpour, Vahid
  7. Abstract:
  8. Nowadays, the use of microreactors is receiving a great deal of attention due to the unique characteristics of such systems, such as high surface-to-volume ratio, low material loss, greater safety, and minimizing mass and heat transfer limitations. In this study, the optimization of the continuous-flow synthesis of Plavix by Cu-MOF heterogeneous catalyst utilizing a glass microreactor was investigated. Structural characteristics of the catalyst were investigated using X-ray diffraction spectroscopy (XRD), Fourier-transform infrared spectroscopy (FTIR), Scanning electron microscopy (SEM), and BET surface area studies to describe the structure and morphology of the catalyst. In order to build the glass microreactor, laser engraving and thermal bonding methods were selected. To find the best reaction conditions to achieve maximum yield, the parameters of residence time, reaction temperature, and catalyst loading were investigated. The results show that using the microreactor system, in a time of 25 minutes, temperature of 55 °C, and a catalyst amount of 4 mg, the reaction yield reaches 48.8%, allowing the synthesis of Plavix to be carried out in a shorter time and with less catalyst amount compared to the batch system. In addition, to investigate the continuous mixing of reactants, a micromixer was simulated using COMSOL software and the effect of baffle geometry, baffle size, and number of mixing units on the micromixer performance was investigated. The results show that the micromixer obtains a mixing index above 90% at all Reynolds numbers when using a cylindrical baffle with a diameter of 200 μm and 4 mixing units.
  9. Keywords:
  10. Microreactor ; Micromixer ; Computational Fluid Dynamics (CFD) ; Metal-Organic Framework ; Heterogeneous Catalysis ; Plavix Drug ; Continuous-Flow Synthesis

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