Sharif Digital Repository

Polycaprolactone (PCL) scaffolds and its composites containing bioactive glass particles (45S5) and TiO2 nanostructures with pre-defined and controlled external and internal architecture were prepared via an indirect three-dimensional (3D) printing process. The scaffolds had an interconnected structure with macro- (400-500 μm) and micro- (~25 μm) pores. Bioactivity, mechanical behavior and kinetics of tissue growth in 3D scaffolds were studied. The size effect of biogactive glass particles (6 μm, 250 nm, <100 nm) and morphology of titania nanostructures (spherical, tube, leaf-like, and flower-like particles) were elaborated. The biogactive glass particles with different sizes were prepared... 

Recently, diamond nanoparticles have attracted interest for biomedical applications such as drug delivery, targeted cancer therapies, fabrication of tissue scaffolds and biosensors. In the present work, elecrophoretic deposition (EPD) of nanodiamond-bioactive glass-alginate nanocomposite was studied. In vitro bioactivity and biocompatibility of the nanocomposite were evaluated in simulated body fluid (SBF) and by MTT assay. The EPD process was performed under different conditions in order to obtain a uniform coating on the surface of 316L stainless steel substrate. The stability of the suspension was determined via optical sedimentation method and zeta potential analysis. It was found that... 

Bioactive glasses are able to bond to soft and hard tissues in living body and their application as coating on metallic implants like 316L stainless steel has two important effects: (1) intimate link between bone and materials and (2) corrosion protection of metallic implant in body fluid and protection from tissues in front of corrosion products. Therefore, in this research, 45S5 bioactive glass prepared via sol- gel method was dip coated on 316L stainless steel substrates and its characteristics was investigated.Results of phase analysis showed that by sintering 45S5 bioglass at 600 ˚C for 5 h, an amorph sample with small amount of Na2Ca2Si3O9 was obtained. So, the bioglass coated samples... 

Implant-associated infections are one of the most serious complications in orthopaedic and trauma surgery as it may result in poor functional outcome, implant failure, chronic osteomyelitis or even death. Great concerns have been taken to reduce implant-associated infections through progressing in operating standards, minimizing the possibility of contamination during surgery, reducing the establishment of infection by perioperative antibiotic prophylaxis, and confining of pathogenic strains by patient isolation. In spite of these preventions, the percentage of postoperative infections is still rising. Composite coatings with bone-bioactivity and drug-eluting capacity are considered as... 

By consideration of increasing demands to use implants and efforts to get technical knowledge and localization of this implants, considerable research in this field is needed. Therefore, presentation of a coating which is able to provide parameters needed for an acceptable implant is the aim of this study. In this direction, modification of surface of metallic implants in order to achieve nanotubes of titanium oxide, with the purpose of providing biocompatibility was done. On the other hand, because chronic infection of the implant’s surrounding is one of the main important reasons in rejection of implants, 〖TiO〗_2 nanotubes as a drug carrier were used in order to solve this problem. So,... 

This research work deals with application of poly-saccharide to improve coating process of bioactive ceramic composite on aNd-Fe-B magnetic alloy substrate. Bioactive glass particles were synthesized through a sol-gel process and coated in the form of composite with poly-saccharide onto a magnetic substrate by electrophoretic deposition technique. Stable suspensions of 0.5 gr/lit polysaccharide polymer-ceramic were prepared using bioactive glass particles (<1µm), acetic acid 1%. The influence of added water to ethanol, pH and tri-ethanol-amine (TEA) additive on suspension stability, deposition rate and coating’s structure was investigated. It was shown that by increasing the water to ethanol... 

Aseptic loosening and infection are two major problems of bone implants. Aseptic loosening occurs due to poor cell growth and poor adhesion to the implant surface over time. Bone infection at the implant site occurs mainly by the staphylococcus aureus bacteria. In some cases, infection occurs in the short term and in the early times after implantation, and in some cases, infection occurs in later times. The aim of this study is to synthesize and evaluate antibacterial coatings, while having cell growth-promoting components and cell differentiation to solve bone implant problems simultaneously. Also, the issue of bacterial resistance to antibiotics and their risks in bone implants is another... 

Currently, using biocompatible and injectable polymeric microcarriers as one of the efficient methods to transfer cells and active agents has gained much attention for bone regenerative medicine. However, they have some drawbacks such as weak mechanical stability and lack of mineral materials, which are the major ingredients of the bone tissues. Accordingly, it is expected that mimicking the chemical and physical structure of bone tissues could be valuable in their medical applications. Herein, a new porous biodegradable microcarriers (MCs) made of silk fibroin-oxidized alginate-bioactive glass was fabricated by electrospraying method. Response surface methodology (RSM) was used to study the... 

Understanding biological systems requires extensive knowledge of individual parameters, and to study the processes of cell differentiation and cell behavior, a suitable environment must be created with the physiological conditions of the human body. For this purpose, with the knowledge of microfluidics, a microenvironment can be provided to study the behavior of cells on a small scale. The use of bone tissue model microfluidic chips is an alternative and new method in which it is possible to study the behavior of cells to differentiate into bone and to examine the toxicity of drugs, which in itself can help in the effective and successful treatment of these cases show. Therefore, in this... 

In the upcoming research, with the aim of bone tissue engineering and achieving a new structure, a scaffold based on polyhema (PHEMA) and gelatin (Gel), which are biocompatible polymers for bone tissue, was made and evaluated. Also, in order to improve the bioactivity and mechanical properties, bioactive glass alone (BG45S5) or together with strontium (BG-Sr) was used in the scaffold structure. and chemical by conducting FTIR, XRD, SEM, mechanical strength, bioactivity measurement, contact angle, water absorption and degradation tests. Biological investigations were done using mesenchymal stem cells derived from human bone marrow and with the help of MTT evaluations and SEM photography. The... 

In this work, we have used a 3D printer and unidirectional ice-templating technique in conjunction, to fabricate a novel composite scaffold to facilitate local osteochondral defects tissue regeneration with a cell-free approach. Using ice-templating to induce radially-aligned porosity formation in type I bovine collagen is known to expedite host cells' migration into the scaffold which their ECM secretion shifts cellular milieu toward that of its neighboring tissue layer. We used numerical analysis to design and optimize appropriate freeze-casting mold, finding the optimum value for pin height and metal slab depth to be 4mm and 14mm, respectively. Collagen content equivalent to 2%w/v was... 

Wound healing is a complex and regular process. It makes more challenge when the volume of wound exudate becomes uncontrollable. To solve this problem, hydrofiber wound dressings which contain carboxymethyl cellulose fibers are being used. Fast absorption and keeping the moisture in balance specially in chronic wounds, is one of the major features of hydrofiber wound dressings. In this research, which was conducted with the aim of investigating the synergy effect of active glasses and Hydrofiber commercial wound dressing for the healing of skin wounds, especially chronic wounds, the sol-gel method has been used to synthesize bioactive glasses based on borosilicate, replacing a part of CaO... 

PMMA bone cement lacks biodegradability and the ability to bond with surrounding bone tissue. Therefore, the development of a new generation of bioactive bone cements that are biodegradable and possess adequate mechanical properties as well as desirable setting time is receiving remarkable interest.In this study, we have developed novel mineral-based bioactive bone cements. Our mineral bioactive bone cements were composed of Calcium Sulfate Hemihydrate, Bioactive Glass, and Tricalcium Silicate. Firstly, a binary system composed of Calcium Sulfate Hemihydrate and Bioactive Glass was optimized based on mechanical and setting behavior. Secondly, Tricalcium Silicate was added to the powder phase...