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Total 62 records

    Tissue growth into three-dimensional composite scaffolds with controlled micro-features and nanotopographical surfaces

    , Article Journal of Biomedical Materials Research - Part A ; Volume 101, Issue 10 , 2013 , Pages 2796-2807 ; 15493296 (ISSN) Tamjid, E ; Simchi, A ; Dunlop, J. W. C ; Fratzl, P ; Bagheri, R ; Vossoughi, M ; Sharif University of Technology
    2013
    Abstract
    Controlling topographic features at all length scales is of great importance for the interaction of cells with tissue regenerative materials. We utilized an indirect three-dimensional printing method to fabricate polymeric scaffolds with pre-defined and controlled external and internal architecture that had an interconnected structure with macro- (400-500 μm) and micro- (∼25 μm) porosity. Polycaprolactone (PCL) was used as model system to study the kinetics of tissue growth within porous scaffolds. The surface of the scaffolds was decorated with TiO2 and bioactive glass (BG) nanoparticles to the better match to nanoarchitecture of extracellular matrix (ECM). Micrometric BG particles were... 

    Dynamic comparison of segmentary scapulohumeral rhythm between athletes with and without impingement syndrome

    , Article Iranian Journal of Radiology ; Vol. 11, issue. 2 , 2014 Taghizadeh Delkhoush, C ; Maroufi, N ; Ebrahimi Takamjani, I ; Farahmand, F ; Shakourirad, A ; Haghani, H ; Sharif University of Technology
    Abstract
    Background: Patients who have shoulder pain usually have compensatory or contributory deviation of shoulder motion during arm elevation. In the traditional scapulohumeral rhythm, the share of the acromioclavicular (AC) and the sternoclavicular (SC) joint movements and also the role of AC internal rotation angle are unknown. Objectives: The main purpose of this study was to measure and compare the segmentary scapulohumeral rhythm (SSHR) during scapular arm elevation at a steady rotational speed in athletes with and without impingement syndrome. Patients and Methods: Using a speedometer, the maximum speed of arm elevation was measured in 21 men in each of the involved and uninvolved groups.... 

    Lumbopelvic rhythm during forward and backward sagittal trunk rotations: Combined in vivo measurement with inertial tracking device and biomechanical modeling

    , Article Clinical Biomechanics ; Vol. 29, issue. 1 , 2014 , pp. 7-13 ; ISSN: 02680033 Tafazzol, A ; Arjmand, N ; Shirazi-Adl, A ; Parnianpour, M ; Sharif University of Technology
    Abstract
    Background The ratio of total lumbar rotation over pelvic rotation (lumbopelvic rhythm) during trunk sagittal movement is essential to evaluate spinal loads and discriminate between low back pain and asymptomatic population. Methods Angular rotations of the pelvis and lumbar spine as well as their sagittal rhythm during forward flexion and backward extension in upright standing of eight asymptomatic males are measured using an inertial tracking device. The effect of variations in the lumbopelvic ratio during trunk flexion on spinal loads is quantified using a detailed musculoskeletal model. Findings The mean of peak voluntary flexion rotations of the thorax, pelvis, and lumbar was 121 (SD... 

    Biomechanical simulation of eye-airbag impacts during vehicle accidents

    , Article Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine ; Volume 232, Issue 7 , 2018 , Pages 699-707 ; 09544119 (ISSN) Shirzadi, H ; Zohoor, H ; Naserkhaki, S ; Sharif University of Technology
    SAGE Publications Ltd  2018
    Abstract
    Airbags are safety devices in vehicles effectively suppressing passengers’ injuries during accidents. Although there are still many cases of eye injuries reported due to eye-airbag impacts in recent years. Biomechanical approaches are now feasible and can considerably help experts to investigate the issue without ethical concerns. The eye-airbag impact–induced stresses/strains in various components of the eye were found to investigate the risk of injury in different conditions (impact velocity and airbag pressure). Three-dimensional geometry of the eyeball, fat and bony socket as well as the airbag were developed and meshed to develop a finite element model. Nonlinear material properties of... 

    Uncontrolled manifold analysis of gait kinematic synergy during normal and narrow path walking in individuals with knee osteoarthritis compared to asymptomatic individuals

    , Article Journal of Biomechanics ; Volume 141 , 2022 ; 00219290 (ISSN) Shafizadegan, Z ; Sarrafzadeh, J ; Farahmand, F ; Salehi, R ; Rasouli, O ; Sharif University of Technology
    Elsevier Ltd  2022
    Abstract
    Knee osteoarthritis (KOA) is a common musculoskeletal disorder resulting in altered gait patterns. Uncontrolled manifold (UCM) analysis has been demonstrated as a useful approach for quantitative analysis of motor variability and synergies. The present study aimed to investigate the changes in the kinematic synergy, controlling the center of mass (COM) position while walking on normal and narrow paths in people with KOA compared to asymptomatic participants. In this cross-sectional study, twenty people with mild to moderate KOA and twenty asymptomatic individuals walked at their comfortable preferred speed across normal and narrow paths on a treadmill. The UCM analysis was performed... 

    Is there a reliable and invariant set of muscle synergy during isometric biaxial trunk exertion in the sagittal and transverse planes by healthy subjects?

    , Article Journal of Biomechanics ; Volume 48, Issue 12 , Sep , 2015 , Pages 3234-3241 ; 00219290 (ISSN) Sedaghat Nejad, E ; Mousavi, S. J ; Hadizadeh, M ; Narimani, R ; Khalaf, K ; Campbell Kyureghyan, N ; Parnianpour, M ; Sharif University of Technology
    Elsevier Ltd  2015
    Abstract
    It has been suggested that the central nervous system simplifies muscle control through basic units, called synergies. In this study, we have developed a novel target-matching protocol and used non-negative matrix factorization (NMF) technique to extract trunk muscle synergies and corresponding torque synergies. Isometric torque data at the L5/S1 level and electromyographic patterns of twelve abdominal and back muscles from twelve healthy participants (five females) were simultaneously recorded. Each participant performed a total number of 24 isometric target-matching tasks using 12 different angular directions and 2 levels of uniaxial and biaxial exertions. Within- and between-subject... 

    Phenomenological tissue fracture modeling for an Endoscopic Sinus and Skull Base Surgery training system based on experimental data

    , Article Medical Engineering and Physics ; Volume 68 , 2019 , Pages 85-93 ; 13504533 (ISSN) Sadeghnejad, S ; Farahmand, F ; Vossoughi, G ; Moradi, H ; Mousa Sadr Hosseini, S ; Sharif University of Technology
    Elsevier Ltd  2019
    Abstract
    The ideal simulator for Endoscopic Sinus and Skull Base Surgery (ESSS)training must be supported by a physical model and provide repetitive behavior in a controlled environment. Development of realistic tissue models is a key part of ESSS virtual reality (VR)-based surgical simulation. Considerable research has been conducted to address haptic or force feedback and propose a phenomenological tissue fracture model for sino-nasal tissue during surgical tool indentation. Mechanical properties of specific sino-nasal regions of the sheep head have been studied in various indentation and relaxation experiments. Tool insertion at different indentation rates into coronal orbital floor (COF)tissue is... 

    Trajectory of human movement during sit to stand: A new modeling approach based on movement decomposition and multi-phase cost function

    , Article Experimental Brain Research ; Volume 229, Issue 2 , 2013 , Pages 221-234 ; 00144819 (ISSN) Sadeghi, M ; Andani, M. E ; Bahrami, F ; Parnianpour, M ; Sharif University of Technology
    2013
    Abstract
    The purpose of this work is to develop a computational model to describe the task of sit to stand (STS). STS is an important movement skill which is frequently performed in human daily activities, but has rarely been studied from the perspective of optimization principles. In this study, we compared the recorded trajectories of STS with the trajectories generated by several conventional optimization-based models (i.e., minimum torque, minimum torque change and kinetic energy cost models) and also with the trajectories produced by a novel multi-phase cost model (MPCM). In the MPCM, we suggested that any complex task, such as STS, is decomposable into successive motion phases, so that each... 

    Design and development of a hand robotic rehabilitation device for post stroke patients

    , Article Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference ; 2009 , Pages 5026-5029 ; 1557170X (ISSN) Rashedi, E ; Mirbagheri, A ; Taheri, B ; Farahmand, F ; Vossoughi, G. R ; Parnianpour, M ; Sharif University of Technology
    Abstract
    Robot-mediated rehabilitation is a rapidly advancing discipline that seeks to develop improved treatment procedures using new technologies, e.g., robotics, coupled with modern theories in neuroscience and rehabilitation. A robotic device was designed and developed for rehabilitation of upper limbs of post stroke patients. A novel force feedback bimanual working mode provided real-time dynamic sensation of the paretic hand. Results of the preliminary clinical tests revealed a quantitative evaluation of the patient's level of paresis and disability  

    Comparative evaluation of six quantitative lifting tools to estimate spine loads during static activities

    , Article Applied Ergonomics ; Volume 48 , 2015 , Pages 22-32 ; 00036870 (ISSN) Rajaee, M. A ; Arjmand, N ; Shirazi Adl, A ; Plamondon, A ; Schmidt, H ; Sharif University of Technology
    Elsevier Ltd  2015
    Abstract
    Different lifting analysis tools are commonly used to assess spinal loads and risk of injury. Distinct musculoskeletal models with various degrees of accuracy are employed in these tools affecting thus their relative accuracy in practical applications. The present study aims to compare predictions of six tools (HCBCF, LSBM, 3DSSPP, AnyBody, simple polynomial, and regression models) for the L4-L5 and L5-S1 compression and shear loads in twenty-six static activities with and without hand load. Significantly different spinal loads but relatively similar patterns for the compression (R2>0.87) were computed. Regression models and AnyBody predicted intradiscal pressures in closer agreement with... 

    A novel coupled musculoskeletal finite element model of the spine – Critical evaluation of trunk models in some tasks

    , Article Journal of Biomechanics ; Volume 119 , 2021 ; 00219290 (ISSN) Rajaee, M. A ; Arjmand, N ; Shirazi Adl, A ; Sharif University of Technology
    Elsevier Ltd  2021
    Abstract
    Spine musculoskeletal (MS) models make simplifying assumptions on the intervertebral joint degrees-of-freedom (rotational and/or translational), representation (spherical or beam-like joints), and properties (linear or nonlinear). They also generally neglect the realistic structure of the joints with disc nuclei/annuli, facets, and ligaments. We aim to develop a novel MS model where trunk muscles are incorporated into a detailed finite element (FE) model of the ligamentous T12-S1 spine thus constructing a gold standard coupled MS-FE model. Model predictions are compared under some tasks with those of our earlier spherical joints, beam joints, and hybrid (uncoupled) MS-FE models. The coupled... 

    A multi-objective approach to optimize the weight and stress of the locking plates using finite element modeling

    , Article Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine ; Volume 236, Issue 2 , 2022 , Pages 188-198 ; 09544119 (ISSN) Rafiei, S ; Nourani, A ; Chizari, M ; Sharif University of Technology
    SAGE Publications Ltd  2022
    Abstract
    This paper aims to identify an optimum bone fracture stabilizer. For this purpose, three design variables including the ratio of the screw diameter to the plate width at three levels, the ratio of the plate thickness to the plate width at three levels, and the diameter of the bone at two levels were selected for analysis. Eighteen 3D verified finite element models were developed to examine the effects of these parameters on the weight, maximum displacement and maximum von Mises stress of the fixation structure. Considering the relations between the inputs and outputs using multivariate regression, a genetic algorithm was used to find the optimal choices. Results showed that the diameter of... 

    Design optimization of an above-knee prosthesis based on the kinematics of gait

    , Article 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08, Vancouver, BC, 20 August 2008 through 25 August 2008 ; 2008 , Pages 4274-4277 ; 9781424418152 (ISBN) Pejhan, S ; Farahmand, F ; Parnianpour, M ; Sharif University of Technology
    2008
    Abstract
    A dynamic model of an above-knee prosthesis during the complete gait cycle was developed. The model was based on a two-dimensional multi-body mechanical system and included a hydraulic and an elastic controller for the knee and a kinematical driver controller for the prosthetic ankle. The equations of motion were driven using Lagrange method. Simulation of the foot contact was conducted using a two-point penetration contact model. The knee elastic and hydraulic controller units, the knee extension stop, and the kinematical driver controller of the ankle were represented by a spring and a dashpot, a nonlinear spring, and a torsional spring-damper within a standard prosthetic configuration.... 

    Rehabilitation after ACL injury: A fluoroscopic study on the effects of type of exercise on the knee sagittal plane arthrokinematics

    , Article BioMed Research International ; Volume 2013 , July , 2013 ; 23146133 (ISSN) Norouzi, S ; Esfandiarpour, F ; Shakourirad, A ; Salehi, R ; Akbar, M ; Farahmand, F ; Sharif University of Technology
    2013
    Abstract
    A safe rehabilitation exercise for anterior cruciate ligament (ACL) injuries needs to be compatible with the normal knee arthrokinematics to avoid abnormal loading on the joint structures. The objective of this study was to measure the amount of the anterior tibial translation (ATT) of the ACL-deficient knees during selective open and closed kinetic chain exercises. The intact and injured knees of fourteen male subjects with unilateral ACL injury were imaged using uniplanar fluoroscopy, while the subjects performed forward lunge and unloaded/loaded open kinetic knee extension exercises. The ATTs were measured from fluoroscopic images, as the distance between the tibial and femoral reference... 

    Lower extremity kinematic analysis in male athletes with unilateral anterior cruciate reconstruction in a jump-landing task and its association with return to sport criteria

    , Article BMC Musculoskeletal Disorders ; Volume 20, Issue 1 , 2019 ; 14712474 (ISSN) Norouzi, S ; Esfandiarpour, F ; Mehdizadeh, S ; Yousefzadeh, N. K ; Parnianpour, M ; Sharif University of Technology
    BioMed Central Ltd  2019
    Abstract
    Background: Return to sport (RTS) criteria are widely being used to identify anterior cruciate ligament reconstructed (ACLR) athletes ready to return to sportive activity and reduce risk of ACL re-injury. However, studies show a high rate of ACL re-injury in athletes who passed RTS criteria. This indicates that the current RTS criteria might not be sufficient to determine return to sport time in ACLR athletes. Previous studies have reported a close association between altered lower limb kinematics and ACL re-injury. However, it is not clear how lower extremity kinematics differs between ACLR athletes who passed the RTS-criteria and who failed. This study compared lower extremity kinematics... 

    Anxiety and cognitive load affect upper limb motor control in Parkinson's disease during medication phases

    , Article Annals of the New York Academy of Sciences ; Volume 1494, Issue 1 , 2021 , Pages 44-58 ; 00778923 (ISSN) Nodehi, Z ; Mehdizadeh, H ; Azad, A ; Mehdizadeh, M ; Reyhanian, E ; Saberi, Z. S ; Meimandi, M ; Soltanzadeh, A ; Roohi Azizi, M ; Vasaghi Gharamaleki, B ; Parnianpour, M ; Khalaf, K ; Taghizadeh, G ; Sharif University of Technology
    John Wiley and Sons Inc  2021
    Abstract
    Anxiety is among the most debilitating nonmotor symptoms of Parkinson's disease (PD). This study aimed to determine how PD patients with low and high levels of anxiety (LA-PD and HA-PD, respectively) compare with age- and sex-matched controls at the level of motor control of reach-to-grasp movements during single- and dual-task conditions with varying complexity. Reach-to-grasp movement kinematics were assessed in 20 LA-PD, 20 HA-PD, and 20 sex- and age-matched healthy controls under single- as well as easy and difficult dual-task conditions. Assessment of PD patients was performed during both the on- and off-drug phases. The results obtained during dual-task conditions reveal deficits in... 

    A regenerative approach towards recovering the mechanical properties of degenerated intervertebral discs: Genipin and platelet-rich plasma therapies

    , Article Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine ; Volume 231, Issue 2 , 2017 , Pages 127-137 ; 09544119 (ISSN) Nikkhoo, M ; Wang, J. L ; Abdollahi, M ; Hsu, Y. C ; Parnianpour, M ; Khalaf, K ; Sharif University of Technology
    SAGE Publications Ltd  2017
    Abstract
    Degenerative disc disease, associated with discrete structural changes in the peripheral annulus and vertebral endplate, is one of the most common pathological triggers of acute and chronic low back pain, significantly depreciating an individual's quality of life and instigating huge socioeconomic costs. Novel emerging therapeutic techniques are hence of great interest to both research and clinical communities alike. Exogenous crosslinking, such as Genipin, and platelet-rich plasma therapies have been recently demonstrated encouraging results for the repair and regeneration of degenerated discs, but there remains a knowledge gap regarding the quantitative degree of effectiveness and... 

    Trunk coordination in healthy and chronic nonspecific low back pain subjects during repetitive flexion-extension tasks: Effects of movement asymmetry, velocity and load

    , Article Human Movement Science ; Volume 45 , 2016 , Pages 182-192 ; 01679457 (ISSN) Mokhtarinia, H. R ; Sanjari, M. A ; Chehrehrazi, M ; Kahrizi, S ; Parnianpour, M ; Sharif University of Technology
    Elsevier 
    Abstract
    Multiple joint interactions are critical to produce stable coordinated movements and can be influenced by low back pain and task conditions. Inter-segmental coordination pattern and variability were assessed in subjects with and without chronic nonspecific low back pain (CNSLBP). Kinematic data were collected from 22 CNSLBP and 22 healthy volunteers during repeated trunk flexion-extension in various conditions of symmetry, velocity, and loading; each at two levels. Sagittal plane angular data were time normalized and used to calculate continuous relative phase for each data point. Mean absolute relative phase (MARP) and deviation phase (DP) were derived to quantify lumbar-pelvis and... 

    Improved artificial neural networks for 3D body posture and lumbosacral moment predictions during manual material handling activities

    , Article Journal of Biomechanics ; Volume 131 , 2022 ; 00219290 (ISSN) Mohseni, M ; Aghazadeh, F ; Arjmand, N ; Sharif University of Technology
    Elsevier Ltd  2022
    Abstract
    Body posture measurement approaches, required in biomechanical models to assess risk of musculoskeletal injuries, are usually costly and/or impractical for use in real workplaces. Therefore, we recently developed three artificial neural networks (ANNs), based on measured posture data on several individuals, to predict whole body 3D posture (coordinates of 15 markers located on body's main joints), segmental orientations (Euler angles of 14 body segments), and lumbosacral (L5-S1) moments during static manual material handling (MMH) activities (ANNPosture, ANNAngle, and ANNMoment, respectively). These ANNs require worker's body height, body weight (only for ANNMoment), hand-load 3D position,... 

    Effect of geometry on the fixation strength of anterior cruciate ligament reconstruction using bashti technique

    , Article Journal of Knee Surgery ; Volume 35, Issue 5 , 2022 , Pages 539-547 ; 15388506 (ISSN) Moeinnia, H ; Nourani, A ; Borjali, A ; Mohseni, M ; Ghias, N ; Korani, H ; Chizari, M ; Sharif University of Technology
    Georg Thieme Verlag  2022
    Abstract
    The goal of this study is to investigate the effects of tendon and cannulated drill bit diameter on the strength of the bone and site hold tendon inside (BASHTI) fixation technique for an anterior cruciate ligament (ACL) reconstruction. Bovine digital tendons and Sawbones blocks were used to mimic the ACL reconstruction. Mechanical strength of the specimens was measured using a cyclic loading continued by a single cycle pullout load until failure to simulate the real postsurgical loading conditions. Finally, failure modes of specimens and ultimate failure load were recorded. The maximum possible tendon surface strain (i.e., tendon compression [TC]) for tendon diameters of 6, 7, 8, and 9 mm...