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    Investigating the effects of precursor concentration and gelling parameters on droplet-based generation of Ca-Alginate microgels: identifying new stable modes of droplet formation

    , Article Materials Today Chemistry ; Volume 24 , 2022 ; 24685194 (ISSN) Besanjideh, M ; Rezaeian, M ; Mahmoudi, Z ; Shamloo, A ; Kazemzadeh Hannani, S ; Sharif University of Technology
    Elsevier Ltd  2022
    Abstract
    Droplet-based microfluidics is an attractive approach for producing microgels due to its high potential to control the size and shape of the particles and precisely entrap the substances within the hydrogel matrix. However, the microfluidic generation of monodisperse microgels with desired structures is still challenging. Indeed, the rheological and interfacial properties of the immiscible fluids, as well as the adopted gelling strategy, play important roles in microfluidic methods. Herein, sodium alginate droplets with different concentrations are generated via a microfluidic device with a flow-focusing unit. Besides, a combined in situ and ex situ strategy is optimized to crosslink sodium... 

    Enhanced oil-in-water droplet generation in a T-junction microchannel using water-based nanofluids with shear-thinning behavior: A numerical study

    , Article Physics of Fluids ; Volume 33, Issue 1 , 2021 ; 10706631 (ISSN) Besanjideh, M ; Shamloo, A ; Kazemzadeh Hannani, S ; Sharif University of Technology
    American Institute of Physics Inc  2021
    Abstract
    Nanofluids are widely used as the continuous phase during droplet formation in microsystems due to their impressive features such as excellent thermal, magnetic, and interfacial properties. Although it is well-known that nanofluids are susceptible to exhibit non-Newtonian behavior even at a low concentration of nanoparticles, effects of non-Newtonian behavior of nanofluids have not been studied on droplet formation thus far. In this study, oil-in-water droplet formation with a relatively high viscosity ratio of the immiscible phases was studied numerically in a T-junction microchannel. To inspect the non-Newtonian effects of aqueous nanofluids on droplet formation, empirical data on the... 

    Ferrofluid droplet breakup process and neck evolution under steady and pulse-width modulated magnetic fields

    , Article Journal of Molecular Liquids ; Volume 343 , 2021 ; 01677322 (ISSN) Bijarchi, M.A ; Favakeh, A ; Mohammadi, K ; Akbari, A ; Shafii, M. B ; Sharif University of Technology
    Elsevier B.V  2021
    Abstract
    Numerous applications in engineering and biotechnology have attracted the attention of many researchers to the analysis of underlying physical phenomena during the droplet pinch-off. In this study, the neck evolution during the formation of a ferrofluid droplet from a capillary is investigated under two types of magnetic field for a drop-on-demand system. The two types are steady and Pulse-Width Modulated (PWM) magnetic fields. First, under steady magnetic field, the necking process is studied for different values of magnetic Bond number and various angles between magnetic coil centerline and gravity. Subsequently, self-similar behavior in the vicinity of the detachment moment is observed.... 

    Shear-thinning droplet formation inside a microfluidic T-junction under an electric field

    , Article Acta Mechanica ; Volume 232, Issue 7 , 2021 , Pages 2535-2554 ; 00015970 (ISSN) Amiri, N ; Honarmand, M ; Dizani, M ; Moosavi, A ; Kazemzadeh Hannani, S ; Sharif University of Technology
    Springer  2021
    Abstract
    Researchers usually simplify their simulations by considering the Newtonian fluid assumption in microfluidic devices. However, it is essential to study the behavior of real non-Newtonian fluids in such systems. Moreover, using the external electric or magnetic fields in these systems can be very beneficial for manipulating the droplet size. This study considers the simulation of the process of non-Newtonian droplets’ formation under the influence of an external electric field. The novelty of this study is the use of a shear-thinning fluid as the droplet phase in this process, which has been less studied despite its numerous applications. The effects of an external electric field on this... 

    The effect of a non-uniform pulse-width modulated magnetic field with different angles on the swinging ferrofluid droplet formation

    , Article Journal of Industrial and Engineering Chemistry ; Volume 84 , 2020 , Pages 106-119 Bijarchi, M. A ; Favakeh, A ; Shafii, M. B ; Sharif University of Technology
    Korean Society of Industrial Engineering Chemistry  2020
    Abstract
    In this study, ferrofluid droplet formation from a nozzle in the presence of a non-uniform Pulse-Width Modulated (PWM) magnetic field with different angles was studied experimentally. A Drop-on-Demand platform was introduced and three different regimes of droplet formation were observed. The regime map of the droplet formation was presented. A new type of droplet formation evolution was observed in which the droplet is formed while it is swinging around the nozzle, and the satellite droplet is not generated in this regime. The effects of five important parameters including magnetic flux density, applied magnetic frequency, duty cycle, distance between the nozzle and the center of the upper... 

    Ferrofluid droplet formation from a nozzle using alternating magnetic field with different magnetic coil positions

    , Article Journal of Magnetism and Magnetic Materials ; Volume 498 , 2020 Favakeh, A ; Bijarchi, M. A ; Shafii, M. B ; Sharif University of Technology
    Elsevier B.V  2020
    Abstract
    Ferrofluid has been used in many fields, such as microfluidics, droplet formation, and heat transfer, due to its potential to be attracted in the presence of a magnetic field. Droplet formation, itself, has many applications such as emulsions, 3D micro-printers, MEMS, and electro-sprays. In this study, the mechanism of ferrofluid droplet formation from the nozzle in the presence of an alternating magnetic field was investigated. The magnetic coil was fixed at different angles with respect to gravity and the effect of the alternating magnetic field and the angle of the magnetic coil axis with respect to gravity on the produced droplet volume, satellite droplet, and droplet formation frequency... 

    Axis-switching and breakup of rectangular liquid jets

    , Article International Journal of Multiphase Flow ; Volume 126 , May , 2020 Morad, M. R ; Nasiri, M ; Amini, G ; Sharif University of Technology
    Elsevier Ltd  2020
    Abstract
    The behavior of low-speed liquid jets emerging from rectangular orifices into a quiescent air is studied numerically. After ejection, the rectangular cross-section transforms into an elliptical form along the jet and while axis-switching includes elliptical cross-sections only, the rectangular shape never establishes again. The optimum wavenumber, corresponding to the most dominant wave, is found to be greater in orifices with higher aspect ratios and, as a result, breakup length of the jet will be shorter. The breakup length decreases exponentially with the initial amplitude of disturbances. Moreover, it is observed that the form of final breakup leads to elimination of the satellite... 

    Parametric study of droplet formation and characteristics within microfluidic devices - A case study

    , Article International Journal of Applied Mechanics ; Volume 12, Issue 7 , 2020 Salehi, S. S ; Shamloo, A ; Kazemzadeh Hannani, S ; Sharif University of Technology
    World Scientific  2020
    Abstract
    Droplet-based microfluidics technologies hold great attention in a wide range of applications, including chemical analysis, drug screening, and food industries. This work aimed to describe the effects of different physical properties of the two immiscible phases on droplet formation in a flow-focusing microfluidic device and determining proper flow rates to form a droplet within the desired size range. A numerical model was developed to solve the governing equations of two-phase flow and the results were validated with previous experimental results. The results demonstrate different types of droplet formation regimes from dripping to jetting and different production rates of droplets as a... 

    Mass transfer during drop formation on the nozzle: New flow expansion model

    , Article AIChE Journal ; Volume 52, Issue 3 , 2006 , Pages 895-910 ; 00011541 (ISSN) Javadi, A ; Bastani, D ; Taeibi Rahni, M ; Sharif University of Technology
    2006
    Abstract
    An attempt was made to introduce a new approach for evaluating mass transfer during drop formation via definition of a parameter related to the extent of the convective mixing within the growing drop. For this purpose it was assumed that the entrance of the dispersed flow into the growing drop from the nozzle is analogous to the entrance of the flow from a smaller channel to a larger one. This transfer mechanism has been dubbed the "flow expansion." A global time-dependent Reynolds number of growing drop (Regd) was defined based on the equivalent diameter of growing drop as a length scale and also on a velocity scale, which is obtained using this flow expansion assumption. The results show... 

    Effects of non-dimensional parameters on formation and break up of cylindrical droplets

    , Article 2004 ASME Heat Transfer/Fluids Engineering Summer Conference, HT/FED 2004, Charlotte, NC, 11 July 2004 through 15 July 2004 ; Volume 2 B , 2004 , Pages 1339-1342 Taeibi Rahni, M ; Sharafatmand, S ; Sharif University of Technology
    American Society of Mechanical Engineers  2004
    Abstract
    The consistent behavior of non-dimensional parameters on the formation and break up of large cylindrical droplets has been studied by direct numerical simulations (DNS). A one-fluid model with a finite difference method and an advanced front tracking scheme was employed to solve unsteady, incompressible, viscous, immiscible, multi-fluid, twodimensional Navier-Stokes equations. This time dependent study allows investigation of evolution of the droplets in different cases. For moderate values of Atwood number (AT), increasing Eotvos number (Eo) explicitly increases the deformation rate in both phenomena. Otherwise, raising the Ohnesorge number (Oh) basically amplifies the viscous effects.... 

    Simulating of Droplet Formation and Calculation of Interfacial Tension by Microfluidic Method

    , M.Sc. Thesis Sharif University of Technology Ghanavati, Ashkan (Author) ; Mohammadi, Ali Asghar (Supervisor)
    Abstract
    Emulsions are the intermittent dispersion of liquid droplets that have many applications such as polymerization, dyeing, cosmetics, food industry, etc. Droplets can be created in a variety of ways, but the most important point in emulsification and the greatest efficiency of its applications is when the formed droplets are uniform. In the emulsification process, there is a key parameter called interfacial tension, which affects the behavior of the formed droplets, such as their stability and morphology, and its precise measurement is very effective in the quality control of the mentioned applications. Be. In this research, droplet formation in microfluidic systems due to uniform droplet... 

    Experimental and Numerical Study of The Production of Alginate Microgels and Cancer Spheroids by Droplet-Based Microfluidic

    , M.Sc. Thesis Sharif University of Technology Rezaeian, Masoud (Author) ; Shamloo, Amir (Supervisor) ; Kazemzadeh Hannani, Siamak (Supervisor)
    Abstract
    Significant advances in biotechnology have led to the emergence of a cost-effective way with less ethical issues to study disease, organ functions, tumors, and their response to drugs besides studying on animals. Microfluidic devices and organ on a chip (tumor on a chip) were introduced to remove those obstacles. Organ on a chip is a powerful tool for studying different types of tissues and simulating diseases, especially cancers, for biological and medical applications. Organ (tumor) on a chip is considered as a smaller scale of the real organ or tumor and it causes to the real-time study of tissues and their functions more accurately. In this study, to fabricate a droplet-based... 

    Numerical Modelling and Experimental Validation of Nano Colloid Droplet Formation in the Electrohydrodynamic 3D Printer

    , Ph.D. Dissertation Sharif University of Technology Mohammadi, Kaivan (Author) ; Movahhedy, Mohammad Reza (Supervisor) ; Khodaygan, Saeed (Supervisor) ; Simchi, Abdolreza (Co-Supervisor) ; Mofrad, Mohammad Reza (Co-Supervisor)
    Abstract
    The electrohydrodynamic (EHD) 3D printing technology is an Additive Manufacturing (AM) method that can be used in the manufacture of submicron-size structures. Due to the multiphysics dynamics and the multiphase nature of the microdroplet formation in the EHD printers, modeling of this phenomenon is complicated. In this thesis, the formation of a droplet in an EHD printer—under a pulsed electrical field—is simulated using a new numerical model which couples the fluid flow, the electric field distribution and the movement of the electric charges under dynamic and transient conditions. The level-set method is applied to the entire multiphysics domain in order to study the formation of the... 

    Experimental and Numerical Investigation of Ferrofluid Droplet Formation under Magnetic Field with Biotechnology Application

    , Ph.D. Dissertation Sharif University of Technology Bijarchi, Mohammad Ali (Author) ; Shafii, Mohammad Behshad (Supervisor)
    Abstract
    Droplet-based microfluidics offers a promising tool in engineering and biomedicine such as drug delivery, biochemistry, sample handling in lab-on-a-chip devices, and tissue engineering. These systems provide the droplets manipulation that can be used as reactors without any contamination for medical purposes. Utilizing magnetic force and ferrofluid droplets can help to better control over the droplet formation and manipulation. Considering the importance of this issue and its rich underlying physics, in this dissertation, ferrofluid droplets formation under a time-dependent, non-uniform magnetic field is studied. A Pulse-Width-Modulation signal (PWM) is utilized to apply the time-dependent... 

    Numerical and Experimental Study of the Effects of Surfactant on Droplet Motion and Deformation

    , Ph.D. Dissertation Sharif University of Technology Salehi, Moloud Sadat (Author) ; Firoozabadi, Bahar (Supervisor) ; Afshin, Hossein (Supervisor)
    Abstract
    Surface Active Agents/surfactant have a strong tendency to adsorb at the interface between two immiscible fluids, due to the existence of hydrophobic portions in their molecules’ structure. Accumulation of these molecules on the liquid interface changes the intermolecular forces and causes the interfacial tension to decrease. Production of drops of the same size at a specified rate and controlling their movement’s speed are among the most important factors effective in the efficiency of processes associated with liquid drops, which could profoundly be influenced by the presence of a small amount of a surface active agent. In this study, the effects of surface active agents on the growth,... 

    Experimental Investigation of Surfactant Effects on Drop Formation of Shear-thinning Liquids

    , M.Sc. Thesis Sharif University of Technology Dastyar, Peyman (Author) ; Firoozabadi, Bahar (Supervisor) ; Afshin, Hossein (Supervisor)
    Abstract
    In this research, the characteristics of non-Newtonian, shear-thinning drop formation containing surfactant from a needle are investigated experimentally. The ambient fluid is air and all experiments have been conducted in a constant flow rate of drop phase fluid. Images of forming drop are taken using a high-speed camera and by processing them, important parameters in drop formation such as length of drop, minimum neck thickness, formation time and the size of satellite drops have been studied. Three non-Newtonian and three Newtonian fluids are considered in a way that the initial viscosity of non-Newtonian fluids would be equal to the viscosity of their corresponding Newtonian fluids.... 

    The Passive Design and Development of Digital Microfluidic Dynamic Memor

    , M.Sc. Thesis Sharif University of Technology Aminizadeh, Javad (Author) ; Moosavi, Ali (Supervisor)
    Abstract
    Microfluidics with the ability to control Nano-to-Pico meter volumes have caused the revolution in the systems of analytical biology and chemistry. However, the most Lab-On-Chip technologies (LOCs) depend on external control elements, so a lab is required to operate a chip. Bubble or drop logic through the bubble (drop) can control the flow internally and intrinsically digitally without utilizing of off-chip or moving components. Non-linearity is applied by using mutual drop-drop' effects on reversible linear flow in low Reynolds. for the proper exploitation of microfluidic systems, It is necessary to control droplet generation systems in one chip appropriately. The most crucial part of the... 

    Numerical Simulation of Flow Focusing Injectors for Liquid Microjet

    , M.Sc. Thesis Sharif University of Technology Hassan Beikian, Somayeh (Author) ; Morad, Mohammad Reza (Supervisor)
    Abstract
    One of the key features of multiphase flow applications is the creation of as little liquid droplets as possible. For example, it is important to use combustion to burn liquid fuels in combustion chambers, fuel-air mixing and complete evaporation of fuel. Liquid fuel should be converted into small droplets and then mixed with air quickly and evaporated. This challenge has been investigated using injectors of various designs and is still being investigated. One of the injectors used is injectors where both gas and liquid are injected into the injector and supplemented with each other. These injectors are referred to as focal injectors, in which gas flows through a typical orifice to... 

    Simulation of Microcapsule Formation for Cell Encapsulation Application

    , M.Sc. Thesis Sharif University of Technology Yaghoobi, Mohammad (Author) ; Saeedi, Mohammad Saeed (Supervisor) ; Kazemzadeh Hanani, Siamak (Co-Advisor)
    Abstract
    Co-culture of different cells is necessary for cancer spheroid formation in preclinical drug tests. It is possible to produce thousands of micro-droplets containing different cells, i.e. microcapsules, in a short time, using droplet microfluidics. However the homogeneity of the cell numbers in the droplets has remained as an unsolved problem.Despite the large amount of experimental efforts to reduce the number of undesirable microcapsules, no one tried to utilize the ease of computer aided simulation for investigating different parameters. In this study, we develop a novel method for capturing cell encapsulation using CFD simulations. The effect of the cell suspension inhomogeneity and... 

    LBM Computational Simulation of Oscillations Caused by Formation and Detachment of Drops

    , M.Sc. Thesis Sharif University of Technology Mardani, Ramin (Author) ; Taeibi Rahni, Mohammad (Supervisor) ; Ebrahimi, Abbas (Supervisor)
    Abstract
    Formation and detachment of drops are of fundamental importance in studying two-phase flows, such as ink jet printing, emulsion, and spray. Drops are formed under the effects of surface tension forces. After formation, forces like gravity detach the drop from the rest of the fluid. The flow rate is varied from dripping to jetting regime. In this project, formation and detachment of drops were simulated, using LBM with phase field model, which can simulate flows with high-density ratios and is a robust method for applying wetting condition on the walls. Results were validated using single-phase and two-phase flows. After code validation, the oscillations caused by formation and detachment of...