Sharif Digital Repository

Dense underflows are continuous currents, caused by interaction of two or more fluids of different density. Density currents move down-slope due their density being heavier than that of the ambient water. In this work, entrainment in 3-D density currents in a straight channel was investigated by a set of experimental studies and Theoretical calculations. Velocity components were measured using Acoustic Doppler Velocimetry (ADV). First of all, the bed shear stress was calculated by the velocity profile method and Reynolds stress method as well and showed a good agreement. By increasing the Richardson number, the bed shear stress decreases. On the other hand, the interface shear stress was... 

Density currents are occurred as a result of the intrusion of a dense fluid into a fluid with a different density. Density difference is the main agent of current’s movement. These currents are observed in nature numerously and they are one of the main reasons of the erosion and transportation of deposition in oceans, seas and rivers. Investigation of these currents is of great importance especially in dams’ reservoir as major cause of deposition and reduction of reservoir’s efficency. Density differences are typically caused by the difference in temperature, existence of solution or insoluble material and suspended solids. In this work, density current is studied experimentally. Density... 

Flows which density difference in a gravity field is their driven force are called Density Currents. Such flows are present in both nature and man made environments. Due to their importance, there have been large efforts to analyse them in both experimental and numerical way. In the present thesis, Smoothed Particle Hydrodynamics (SPH) is introduced as a new tool to simulate such flows. As the method is Lagrangian and particle based, simulation of Density Currents with particles can be addressed more naturally that can be accounted as the method preference to traditional mesh based methods. SPH projection method is incorporated to impose incompressibility. To precisely simulate Density... 

One of the main reasons of brain attack is stenosis in Carotid bifurcation. As a result, it's a major field of interest for a large group of scientists including medical doctors and engineers. In the engineering fields a large number of studies have been done on this topic based on Numerical Simulation. As blood boundary conditions in this region strictly depend on the rest of the body's vascular system, the problem is the definition of the boundary condition in this approach. In addition, because of lack of enough hardware sources simulation of the whole blood system is impossible; thus the rest of the system should be simulated based on radical methods with less details. In this project a... 

Carotid bifurcation is one of the most important bifurcations in human body which has a lot of curvature in some people. The common carotid artery bifurcates into an internal carotid artery (ICA) and an external carotid artery (ECA). The incidence of stenosis in carotid bifurcation and in particular in the internal carotid artery is of special importance. In the United States of America by 2006, nearly 700000 strokes occur each year, with about 160000 deaths and 20 to 30% of strokes are caused by stenotic carotid that cost estimated at $160 billion. The purpose of this thesis is to investigate in hemodynamic factors of blood flow such as velocity variation, vortex patterns, shear stress and... 

The results of numerical simulation of underground flows are greatly affected not only by the discretization method of flow equations, but also by the way that the geological domain is upscaled. Including the detailed knowledge of heterogeneous permeability distribution is mostly neither feasible nor computationally efficient. So it is important to develop efficient grid generation and upscaling methods to simplify the fine-scale flow model while still including the impact of the heterogeneities as far as possible. Thus regions where parameters of interest have larger values or higher changes require finer grid blocks and regions with lower values or minor changes should have coarser grid... 

One of the most important reasons of death in today’s world is the diseases related to cardiovascular system. Hypercholesterolemia is one of the most common forms of these diseases. There are a lot of experiments for diagnosing this disease, which are classified into two groups: invasive and noninvasive experiments. One of the well-known noninvasive experiments in this area is the photoplethysmography in which the changes of the photoplethysmography signal can reveal some valuable information about the cardiovascular system’s health.The objective of this study is to simulate the photoplethysmography experiment considering the clinical conditions of the experiment. In this work, the obtained... 

The urine formation and excretion system has long been of interest for mathematicians and physiologists to elucidate the obscurities within the process happen in renal tissue. In this study, a novel and absolutely three-dimensional approach is utilized for modeling urine concentrating mechanism in rat renal outer medulla which is essentially focused on demonstrating the significance of tubule's architecture revealed in anatomic studies and physiological literature. Since nephrons and vasculatures work interdependently through a highly structured arrangement in outer medulla which is dominated by vascular bundles, a highly detailed functional unit is proposed and also it is strongly justified... 

When a fluid moves inside another fluid while they have unequal density, a phenomena occurs which is called density (or gravity) current. Therefore density difference and gravity are key factors of density current generation. Due to application in engineering and geology, it is essential to investigate and analyze the above mentioned phenomena. Dam reservoirs, sandstorm in deserts, snow slide onset and falling, ash clouds produced during eruption of a volcano, and spreading of density current due to the collapsing of reservoirs are some examples of gravity current. There are lots of methods to simulate the turbulence of density current like DNS or RANS. But DNS has high computational cost... 

In the present thesis, intracellular fluid flows have investigated for study cell motions. It is due to firmly relation between the cell motion and these flows. Generally, the cell firstly adheres to a surface, then, moves forward with the effects of the internal fluid flows. In this study, the cell structure is invided to two general parts; the front part of the cell and the cell body. The front part of the cell plays a essential roles in the cell motion, however, the cell body is considered as a extra cargo that is carried by the front of the cell. Therefor, in the present modellings, the front part is only considered. Here, using four different models for the front part of the cell, many... 

Density currents, caused by the intrusion of dense fluids under lighter ambient fluids, frequently occur in both natural and industrial situations. As a result of the density differences, the driving force can arise from soluble substances, temperature differences, etc. If the driving force comes from suspended particles including silt and mud, the currents are called turbidity currents. Due to the variation in concentration and the consequent driving force along the flow path, turbidity currents are significantly more complicated than saline currents. These currents play the most important role in sedimentation in lakes, seas and oceans. In addition, turbidity currents are the main factor... 

With the increasing development of the pharmaceutical industry and producing drugs with specific performance, its transfer into cells is also very important. Cell membranes are effectively impermeable to hydrophilic compounds unless the permeation is facilitated by dedicated transport systems. This means that many hydrophilic compounds, including many promising drug candidates, fail to reach their intracellular target because they cannot spontaneously cross lipid membranes. As a consequence, there is much interest in finding ways to facilitate the transport of molecules across cell membranes. Cell-penetrating peptides (CPPs) in particular have shown much promise as potential delivery agents... 

In this dissertation, mass transport in cardiovascular system has been simulated using one-dimensional approach. As one-dimensional simulation has computation cost less than that of the three-dimensional simulations, and as it is more precise than lumped models, they are extensively used in the study of the phenomena in cardiovascular system. In addition, such an approach is more useful in the extraction of medical indices. In this study, a one-dimensional geometry of the systemic arteries has been used to solve momentum and continuity equations using characteristics method.
At first, the physiological data of the systemic arteries have been used to simulate a one-dimensional geometry... 

The mathematical analysis of the kidney has always been considered due to its complex performance. It’s about two decades that mathematicians work on the mathematical modeling of this tissue. Since Glomerular filtration of blood in the kidney has been regarded by physiologists for many years, they can access only to the qualitative data. Mathematicians can solve this problem by numerical modeling. In this research, an engineering model is presented for the analysis of this capillary network by investigating in the different scientific fields such as, physiology, medicine, computer science and mathematics.First of all, the homogeneous model introduced by Deen, are studied. The rate of the... 

Turbidity currents are one of the more frequently observed types of stratified flows. In these currents, the density difference is created as a result of particles. Hydrodynamic instabilities at the interface of these currents could occur in various modes and have an important role in the mixing process. The main goal of this study is to investigate the interfacial stability of turbidity current, theoretical and experimentally. The linear stability analysis in temporal and spatial framework are used for studying the stability characteristics of a particle-laden stratified two-layer flow for two different background density profiles: smooth (hyperbolic tangent) and piecewise linear. The... 

Particle retention and clearance is a major concern in the treatment of pulmonary diseases. Inhaled materials into the nasal and lung airways include gases/vapors, liquid droplets and soluble/insoluble particulate matter which can be toxic or therapeutic (or both). For example, nanoparticles (NPs), as part of nanomedicine, are now being used as drug carriers for passive and active targeting of solid tumors and inflamed tissue. However, natural and especially manmade NPs can also be harmful, such as carbon nanotubes (CNTs), asbestos fibers and ambient toxic pollutants, based on epidemiological and pathological studies of occupational and environmental exposures. In fact, ultrafine particles... 

Alzheimer’s disease (AD) is the most common type of dementia in the elderly. The neuropathology and treatment of AD is not precisely determined yet, but according to the pathological studies, AD is associated with presence of toxic soluble oligomers and insoluble senile plaques formed by amyloidosis of Amyloid Beta (Aβ) in neocortical region of brain. An attractive therapeutic approach to treat AD is to identify small ligands that are capable of binding to critical residues in order to inhibit or reverse Aβ amyloidosis process as source of neurotoxicity. In this area, therapeutic efforts designed various organic agents and most of them focused on the N-terminal sequence of Aβ. The aim of... 

In the present study, we are to investigate and calculate the drag coefficient in the secondary bag breakup regime in droplet experiment in which the liquid droplet falls into continuous air jet flow. A high speed camera is hired to record the pictures of this process. With the help of image processing techniques, parameters such as dimensionless diameter, growth of droplet, drag coefficient and etc. in secondary bag breakup regime are investigated. The liquid used in this experiments are water, gasoline and diesel fuel. Dimensionless number influencing the result of the experiment are weber and Ohnesorge numbers, with weber number ranging from 6.86 to 20.31 and Ohnesorge number ranging from... 

The advent of microfluidics as suitable environments for culturing cells is associated with some challenges such as shear stresses applied on the cells. In fact, hepatocytes lose their function as exposed to high shear stresses similar to other cell types. Moreover, among all factors needed for cell viability, feeding hepatocytes with adequate oxygen is of great importance due to their high demand for oxygen compared the other cells. In this thesis, different types of cultures including 2D and 3D has been used in order that shear stresses would be in allowed range and provision of hepatocytes with sufficient oxygen concentrations has been ensured as well. In addition to supplying hepatocytes... 

In the present study, hydrodynamics and particle sedimentation of a rectangular basin is studied numerically. Results are also validated with experimental data. Two major goals are perused in this work: First comparing LES and RNG k-ϵ turbulence models and second, investigating the accuracy of simulation of particle sedimentation by solving the concentration formula.
In order to achieve these goals, a 2D sedimentation tank is simulated using the RNG k-ϵ model. Velocity and concentration profiles are also plotted. Comparing the results with experimental data reveals that simulating sedimentation by the mentioned method has acceptable accuracy and can be used to predict sedimentation. In...