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Synthesis of magnetic bio-nanocomposites for drug release and adsorption applications
, Article South African Journal of Chemical Engineering ; Volume 42 , 2022 , Pages 115-126 ; 10269185 (ISSN) ; Meskini, M ; Qarebaghi, L. M ; Salami, M ; Forouzandehdel, S ; Cheraghali, M ; Sharif University of Technology
Elsevier B.V
2022
Abstract
Aims: Synthesis of nanocarrier Fe3O4/silica-starch/PNVCL for drug delivery and Fe3O4/GO-starch for antibiotic removal applications Background: In the first part, the new magnetic nanocomposite including Fe3O4 nanoparticles coated with silica, anchored starch nanoparticles, and poly(N-vinylcaprolactam) and then, loaded by acetazolamide. In the second part, magnetic starch nanocomposites were synthesized and modified with graphene oxide. Methods: The drug loading, release and intrinsic cytotoxicity were measured. Also, the potential of Fe3O4/GO-starch as an adsorbent to remove cephalexin antibiotics from aqueous solutions was evaluated. Result: In the first part, the maximum drug adsorption...
Synthesis of a novel magnetic starch-alginic acid-based biomaterial for drug delivery
, Article Carbohydrate Research ; Volume 487 , 2020 ; Forouzandehdel, S ; Rezghi Rami, M ; Sharif University of Technology
Elsevier Ltd
2020
Abstract
The magnetic composite hydrogel was fabricated by the graft copolymerization of itaconic acid (IA) onto starch and Alginic acid in the presence graphene sheets (Gr) and Fe3O4 nanoparticles (Fe3O4@Gr-IA/St-Alg) for Guaifenesin (GFN) delivery and wound healing. The Fe3O4@Gr-IA/St-Alg biomaterial is a hydrogel network endowed the material with magnetic property. In addition, GFN not only achieved effectively bound to the magnetic hydrogel, but also released in a controlled manner. The using external magnetic field has significantly positive influence on the drug release rate. To close, these hydrogel drug carriers offer a favorable platform for magnetically targeted drug delivery as well as a...