Sharif Digital Repository

Sonodynamic therapy has been developed over the last century, now it has become more widely used as a medical tool for the treatment of various diseases such as cancer. This technique involves delivery of sonosensitizing drugs, irradiation of ultrasound waves and motivation of drugs. In this thesis surface modification process with polymer and biocompatible surfactant on TiO2 nanoparticles has been done due to stabilization of TiO2 nanoparticles in neutral pH which is similar to inside-body situation. In the last step, for cancer therapy, doxorubicin as a cancer drug was loaded on TiO2 which was surface modified by PVA. The results revealed the best ratio of (PVA: TiO2), (SDS: TiO2), (SDS:... 

To days the heterogeneous material are used extensively in the engineering materials. Optimization ability is a key feature of these materials to reach desired properties. Heterogeneous materials are the materials that make up from the constituents of multiphase materials in lower length scale such as mesoscopic, microscopic or/and Nano scales. So the properties of these materials at each scale are depending on to several characteristics of heterogeneities such as geometry, material and packing. In these materials the effects of heterogeneities at the lower scales are very significant and the constitutive equations are different for each range of scale. The proper selection of this range... 

Combustion sources such as diesel vehicles are the most of the particular matter sources in ambient air. Near the tailpipe, exhaust is very hot, condense and have high velocity. This properties cause to need special methods and instrument to collect them. Numerously of combustion sources will emitted the VOCs, IVOCs, and SVOCs. This component mixed with ambient air and changing to particle phase from gas phase. Reaction between nitrogen oxides with sunlight cause to damage ozone layer and tissue in long time. Furthermore, breathe of VOCs gases cause to eye irritation, gastrointestinal effects, Damage to the nervous system, headache, dizziness, fatigue, vibration and loss of organ... 

Economic aspects of power systems in their new structures, have been the subject of most of new publications in the area of electrical engineering after the era of restructuring. Nowadays, the power generation business is totally market driven in most of countries all around the world and the system operators are responsible for maintaining a high level of system security as well as the economic operation of the power systems. The development of wind power generation has rapidly progressed over the last decade. With the advancement in wind turbine technology, wind energy has become competitive with other fuel-based resources. The fluctuation of wind, however, makes it difficult to optimize the... 

The aim of this study is numerical simulation of progerasive failure in conical structures that manufactured by tape-winding proceses in various temperatures. For this purpose, flat laminates by tape-winding proceses firstly manufactured using carbon/phenolic prepreg tape. Then tensile, compression, shear and thermal expansion coefficient specimens are cut from these laminates. Tensile and compression test are done on these specemens in fiber and matrix directions in temperature range 23-200℃ and stress-strain and stress-time curves are achavied. Using these curves tensile elastic modulus in fiber and matrix directions and Poisson's ratio are obtained in room temperature. Also tensile and... 

Cancer is one of the leading causes of death around the world according to WHO. Scientists’ tried different approaches for treating this illness and from about 100 years ago one of the leading approaches to treat cancer is radiotherapy. With advancement of technology possibility of using different kinds of radiation for this purpose became available and one of the most interesting ones is high energy charged ions. But using high energy charged ions for treatment planning needs deep understanding of its nature and factors that affects the human body cells response to it. This thesis briefly reviewed the working principles of radiation therapy and then investigated two of the most used... 

In this work, hypereutectic Al-20Si-5Fe-2Ni powder was prepared by gas atomizing method. The alloy was fabricated by melting of commercially pure metals and re-melting at approximately 200 K above the liquidus temperature. The molten alloy was then atomized by nitrogen at a gas pressure of 0.8 MPa. The nozzle diameter was 3 mm. The aluminum alloy powders were milled under pure Argon atmosphere with a ball to powder ratio of 10:1 in a planetary ball for 12, 24, 36 and 48 hours. The gas-atomized and milled powders were then consolidated by cold sintering method. Microstructure and phase analysis were performed by SEM and XRD technique. Mechanical properties were evaluated by microhardness and... 

The material presented in thesis uses concepts of finite element and doublet panel method to develop a structural aerodynamic coupled mathematical model for the analysis of morphing wing tip composed of smart materials. Much research is currently being performed within many facets of engineering on the use of smart of intelligent material. Examples of the beneficial characteristics of smart materials might include altering a structure's mechanical properties, controlling its dynamic response and sensing flaw that might progressively become detrimental to the structure. This thesis describes a bio inspired adaptive structure that will be used in morphing an aircraft's wing tip. The actuation... 

One of the main goals in large projects with multiple contractors is to reduce costs in various processes. The complexity of a large project, which is mainly due to the complexity of activities and the existence of interference between different phases and the lack of transparency of activities, can be added to the multiplicity of contractors and the difficulty of proper interface management.As regards that large projects with a large scope of work, have to use several contractors and this issue has a direct impact on increasing project costs, large project management becomes a major challenge that the application of appropriate knowledge, improving processes and skills and tools can play a... 

In the present work, the beginning and progressive growth of delamination in laminated composites plates has been studied. Interlaminar stresses at free edge of laminate may give rise to edge delamination and result in failure of laminate. So we need to determine the exact interlaminar stresses to predict the failure of laminated composites. A computer code based on layerwise theory that can obtain the exact interlaminar stresses been developed. Comparison between the present study and finite element software result showed the good agreement.A fracture mechanics approach is used to analysis delamination propagation between layers of composites laminate. In this approach damage propagation... 

The concept of smart grid to realize the triple goals of economy, reliability and environmental improvements has taken advantage of modern equipment and new structures. Beside these goals smart grids seek to increase the level of penetration of renewable resources for environmental improvement. On the other hand, increase in dispersed products and problems resulting from increasing these non-dispatchable resources thus led the researches to design a new structure called microgrid. Microgrid improves the reliability of these resources and facilities their uses. But uncertainty and intermittency in producing renewable energy resources are among the main challenges facing these microgrids.... 

Isfahan Zirconium Production Plant (ZPP) is one of the most important plants in the nuclear industry of Islamic Republic of Iran. The wastewater of this plant contains high values of Sodium, Chloride, Nitrate and low values of Calcium, Magnesium, Zinc and Zirconium ions. Its release has been banned by international and national law because of the dangers and toxicity of its ions for the environment and living organisms. Therefore, its refinement as a compensation of Iran’s water resources in agriculture and drinking water has received a major consideration. Among the common methods to removal of these ions, membrane process method is selected due to it's major benefits such as not producing... 

The two-dimensional composites are benefited from different advantageous; however, they may not be good enough in terms of strength along the thickness, manufacturing speed, cost management and resistance to delamination. To overcome these unpleasant challenges, the three-dimensional composites are defined as having a 3D pattern of yarns which not only includes yarns along the length and width, but also in thickness or vertical direction. One of these common types of composites is 3D-orthogonal woven composites. In this comprehensive research study, the 3D orthogonal woven composite modelling is conducted through a specialized and advanced software, TexGen software. Then Voxel mesh were... 

In this study, the reconstruction of the neutron noise source in the core of the VVER-1000 reactor was carried out using fuzzy neural network and parallel processing of parallel process circuit design. The noise of power reactors is derived from neutron fluctuations. Which are affected by fluctuations in reactor characteristics. These oscillations can be caused by the displacement of the elements forming the core or due to changes in temperature or density and so on. It is clear that any change in the elements of a reactor will make itself a change in the corresponding to cross-section of material. These changes called as pertubation. In this project, by using neuro-fuzzy network... 

The increasing variability of renewables and volatile chronological net-load in modern smart grids engenders significant operational risks of an uncertain sufficiency of flexible capacity. Assessing the operational flexibility of the grid with high penetration of renewable resources remains an issue of critical importance. Operational flexibility insufficiency may bring about two major problems: 1) there may exist no feasible solution for operation under uncertain conditions due to insufficient available flexibility capacity;2) even if the solution feasibility criterion is ensured, dispatch limitations of the flexible resources may force the system operating point to deviate from the optimal... 

Al /Al3Ti in-situ composite have been fabricated by mechanical alloying and two-step hot pressing of powders containing Al and 20%wt Ti. Samples were characterized by using optical microscopy, density measurement, brinel hardness, XRD analysis. An increasing density was observed with increasing pressure until certain pressure and after that the density of composite decreased, which can be attributed to the increase in the level of porosity level and the amount of forming Al3Ti. The samples that hot pressed under cycle 5 and 6, showed the most volume fraction of in-situ phases on the matrix. The wear behavior of Al based composites reinforced with in situ Al3Ti particles has been investigated... 

Poly (lactate-co-glycolate) is a typical biocompatible and biodegradable synthetic polymer. Addition of TiO2 nanoparticles improved compressive modulus of PLGA scaffolds and reduced fast degradation. Porous 3D scaffolds, which are synthesized using biocompatible and biodegradable materials, could provide suitable microenvironment and mechanical support for optimal cell growth and function. A novel method has been applied to fabricate PLGA/TiO2 scaffolds without using any organic solvent or porogen for nucleation compared to former ways, with aim of improving the biocompatibility, macroscale morphology and well inter-connected pores efficacy: Air-Liquid Foaming. Adjustment of the foaming... 

Iron oxide nanoparticles were synthesized using microemulsion technique as MRI contrast agents. Utilization of nanoparticles for biological applications and in this case as MRI contrast agents needs particles to be of small size and also narrow size distribution. For this aim, the effect of several parameters on size and size distribution has been studied. These parameters include water/surfactant ratio, precursor’s concentration and amount of polymer employed to improve nanoparticles colloidal stability. XRD, FE-SEM and TEM results reveal that the synthesized nanoparticles had small size (about 10 nm iron oxide core and 20 nm overall diameter) and possessed narrow size distribution (15-21... 

Since the beginning of discussion on neutron-gamma discrimination, different methods were suggested for this purpose. In early 2000s, Analogue methods were mainly used to discriminate the spectrum in mixed fields which mostly depends on electronic modules used in the lab setup; Nowadays, with improvements in digital pulse processing techniques, analyzing mixed neutron-gamma fields for pulse discrimination is also available.In this research, the recent MC developed toolkit called GEANT4 is used to simulate the 3-inch BC501A scintillation detector and 500 mCi Am-Be source (that emits neutron and gamma at the same time). For the next step, an experiment with same source and detector was done... 

As a result of technology advancement in composite materials and the growth of analytical tools, applications of these materials is increasing in various industries, especially in aerospace industry. One of the structures developed using these materials is hybrid structure with composite/elastomer layering. Stress analysis and study of free-edge effect in this type of structures is possible by using three-dimensional elasticity in composite layers as well as nonlinear hyperelasticity in elastomeric layers, and this is the topic that this thesis deals with. The proposed approach to solving the problem is that the composite/elastomer hybrid structure is first analyzed by the finite element...